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Traditional Chinese medicine extract capable of resisting fibrosis and preparation method and application thereof

An anti-fibrosis and extract technology, which is applied in the field of gigas japonica extract with treatment of fibrosis and its preparation, can solve problems such as further confirmation and so on.

Active Publication Date: 2014-04-30
四川梓橦宫药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has a certain effect in treating tissue fibrosis. For example, patent CN1439376A discloses a Chinese medicine preparation of Centella asiatica for resisting pulmonary fibrosis, and patent CN1453014A discloses a Chinese medicine preparation for preventing liver fibrosis and treating liver cirrhosis. However, these preparations The extent to which the clinical efficacy can be achieved needs to be further confirmed

Method used

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  • Traditional Chinese medicine extract capable of resisting fibrosis and preparation method and application thereof
  • Traditional Chinese medicine extract capable of resisting fibrosis and preparation method and application thereof
  • Traditional Chinese medicine extract capable of resisting fibrosis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 1kg of the whole plant of S. japonica, add 8 times the amount of 95% ethanol to soak for 1 day, then crush it, add 10 times the amount of 95% ethanol to soak for 2 days to extract, collect the extract, and recover the ethanol under reduced pressure at 50°C until it is free of alcohol Taste, dried to obtain the ethanol extract of the seedlings.

Embodiment 2

[0033] Take 1kg of the stem and leaf of Scutellaria chinensis, add 10 times the amount of 95% ethanol to soak for 1 day, then crush it, then add 10 times the amount of 95% ethanol for reflux extraction, collect the extract, and recover the ethanol under reduced pressure at 60°C until there is no alcohol smell. Dried to obtain the ethanol extract of the seedlings. Adding water to disperse the ethanol extract of the seeds of the safflower, and extracting with petroleum ether and ethyl acetate in sequence to obtain the petroleum ether extract and the ethyl acetate extract of the safflower seeds.

Embodiment 3

[0035] Take 1kg of the whole plant of Scutellaria japonicus, add 10 times the amount of methanol to soak for 1 day, then crush it, then add 8 times the amount of methanol to soak for 2 days, collect the extract, recover methanol under reduced pressure at 40°C, and dry to obtain the safflower methanol For the extract, add water to disperse the methanol extract of the safflower seed, and then extract it with petroleum ether and ethyl acetate in sequence to obtain a petroleum ether extract and an ethyl acetate extract of the safflower seed.

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Abstract

The invention provides a paliurus ramosissimus extract capable of resisting fibrosis well, and a preparation and application thereof. The paliurus ramosissimus extract comprises the major components including flavonoid, terpene, alkaloids, coumarins, polysaccharides, cellulose, and glycosides and monomer compositions of flavonoid, terpene, alkaloids and coumarins. The invention also relates to a preparation method and application of the paliurus ramosissimus extract. The application range covers the application of the paliurus ramosissimus extract individually used in preparation of an anti-fibrosis drug and / or application of a pharmaceutical composition with the paliurus ramosissimus extract as the major active ingredient in preparation of the anti-fibrosis drug.

Description

technical field [0001] The invention relates to the field of extraction and application of traditional Chinese medicines, in particular to an extract of Cercis japonicus for treating fibrosis and its preparation method and application. Background technique [0002] Fibrosis is a pathological process in which inflammation leads to necrosis of organ parenchyma cells, abnormal increase and excessive deposition of extracellular matrix in tissues. The light ones show fibrosis, and the severe ones cause tissue structure damage and organ sclerosis. Fibrosis can occur in a variety of organs. The main pathological changes are the increase of fibrous connective tissue and the reduction of parenchymal cells in organ tissues. Continuous progress can lead to organ structural damage, functional decline, and even failure. It is the main cause of disability and death in many diseases. Statistics show that nearly 45% of the deaths from various diseases in the United States can be attributed...

Claims

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Application Information

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IPC IPC(8): A61K36/72A61K45/00A61P1/16A61P11/00A61P9/00A61P13/12
Inventor 徐超群袁志翔李东晓舒光明张磊李兴平雷玲白筱璐
Owner 四川梓橦宫药业股份有限公司
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