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Pharmaceutical composition and application thereof in preparation of medicines for preventing and treating tumors

A composition and drug technology, applied in the field of pharmaceutical composition and its application in the preparation of anti-tumor drugs, can solve the problems of easy recurrence of diseases, drug resistance, etc.

Pending Publication Date: 2021-06-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such diseases are prone to relapse and drug resistance, making the development of new drug combination mechanisms and strategies a difficult and hot topic for the treatment of such diseases

Method used

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  • Pharmaceutical composition and application thereof in preparation of medicines for preventing and treating tumors
  • Pharmaceutical composition and application thereof in preparation of medicines for preventing and treating tumors
  • Pharmaceutical composition and application thereof in preparation of medicines for preventing and treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Small molecule compound TWS119 combined with bortezomib (Bortezomib, Btz)

[0028] A pharmaceutical composition, the active component of which consists of component A and component B, wherein component A is a small molecule compound TWS119 (purchased from Selleck); component B is bortezomib (Bortezomib, Btz, purchased from Selleck).

[0029] In order to test the inhibitory effect of the pharmaceutical composition in this example on the proliferation of multiple myeloma cells, the above-mentioned pharmaceutical composition or drugs were respectively dissolved in DMSO and then tested under the same conditions. Specifically, the pharmaceutical composition effect test process in the present embodiment is as follows:

[0030] (1) Detection method of apoptosis protein:

[0031] S1: culture LP1 cells in a 24-well plate;

[0032] S2: Add pre-mixed TWS119 (2 μM) and Btz (0.1 μM) to the cells obtained above, and pretreat for 24 hours;

[0033] S3: Western blotting w...

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Abstract

The invention provides a pharmaceutical composition and application thereof in preparation of medicines for preventing and treating tumors, and belongs to the technical field of medicines. The active ingredients of the pharmaceutical composition include a small molecule compound TWS119 or pharmaceutically acceptable salt thereof, and bortezomib or an analogue thereof or pharmaceutically acceptable salt thereof or a stereoisomer. The pharmaceutical composition is applied to the preparation of the medicines for preventing and treating the tumors, and especially has a remarkable effect on multiple myeloma. The TWS119 can enhance the bortezomib sensitivity of multiple myeloma cells, so that the pharmaceutical composition solves the problem of medicine resistance in treatment of the multiple myeloma.

Description

technical field [0001] The invention relates to a pharmaceutical composition, which belongs to the technical field of medicine, in particular to a pharmaceutical composition and its application in preparing anti-tumor drugs. Background technique [0002] Multiple myeloma is a cancer of the blood that results from the deterioration of plasma cells. Multiple myeloma has characteristics such as drug resistance and easy recurrence, making this disease still difficult to cure completely. The marketing of proteasome inhibitor drugs such as Bortezomib (Btz) has greatly prolonged the survival period of multiple myeloma patients. However, single-drug resistance still limits the application of such drugs. Combination drugs are currently used in the treatment of multiple myeloma. [0003] Bortezomib (Btz) has a good effect in the treatment of multiple myeloma, but the resistance to a single drug still limits the application of this type of drug. In recent years, combination therapy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K31/519A61P35/00
CPCA61K38/05A61K31/519A61P35/00A61K2300/00
Inventor 周亮李彦辰邹露
Owner SUZHOU UNIV