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Application of plasma exosomes miR-596

A technology of mir-596 and exosomes, applied in the direction of microbial measurement/testing, biochemical equipment and methods, etc., can solve the problem of unclear prognosis of IPAH patients

Pending Publication Date: 2021-06-18
SHANGHAI PULMONARY HOSPITAL
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Problems solved by technology

Although exosomal miRNAs regulate many key drivers in PAH pathology, whether plasma exosomal miRNAs can predict outcomes in IPAH patients remains unclear

Method used

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  • Application of plasma exosomes miR-596
  • Application of plasma exosomes miR-596
  • Application of plasma exosomes miR-596

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Experimental program
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Embodiment

[0021] ① Research population

[0022] From May 2010 to April 2012, 12 adults (5 males) with newly diagnosed IPAH were recruited as the discovery cohort, and from May 2013 to September 2016, 46 patients (18 males) were recruited Adult patients with newly diagnosed IPAH served as the validation group. IPAH was diagnosed in both groups according to the then-current guidelines of the European Society of Cardiology and the European Respiratory Society. Specifically, the inclusion criteria for the two groups of patients were mPAP ≥ 25 mmHg, mPAWP ≤ 15 mmHg, and PVR > 3WU, and patients who excluded other causes of PAH. Patients with established etiologies associated with PAH, such as connective tissue disease and congenital heart disease, and patients with other pulmonary artery obstruction such as pulmonary hypertension due to left heart disease and chronic thromboembolic pulmonary hypertension were excluded. We also excluded patients with acute or chronic diseases that could affe...

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Abstract

The invention relates to application of a preparation for detecting plasma exosomes miR-596 in preparation of kits for predicting survival rates of patients with idiopathic pulmonary hypertension. According to the application, expressions of the plasma exosomes miR-596 of the IPAH survival patients and expressions of the plasma exosomes miR-596 of the non-survival patients are found different for the first time. The plasma exosome miR-596 can be used as an independent survival rate predictor, and references are provided for clinical prognosis and evaluation of the severity of IPAH of the patients.

Description

technical field [0001] The present invention relates to the technical field of prognosis of idiopathic pulmonary hypertension, in particular to the application of plasma exosome miR-596. Background technique [0002] Idiopathic pulmonary arterial hypertension (IPAH) is a muscular pulmonary arteriolar disease characterized by progressive increases in pulmonary artery pressure and pulmonary vascular resistance (PVR) without apparent cause, eventually leading to death from right heart failure. The gold standard for the diagnosis of IPAH is based on multiple hemodynamic indicators of right heart catheterization (RHC), such as PVR, mean pulmonary artery pressure (mPAP), mean pulmonary artery wedge pressure (mPAWP), etc. In addition to their diagnostic value, some hemodynamic parameters can be used as biomarkers to assess the prognosis of IPAH patients. However, these parameters are obtained through invasive examinations, and better biomarkers are urgently needed to be sorted out...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178C12Q2600/118
Inventor 袁平孙媛媛袁训涛王作刚孙秀英
Owner SHANGHAI PULMONARY HOSPITAL
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