Application of zinc finger protein 750 gene in preparing diagnosis reagent for esophageal squamous cell carcinoma

A technology of esophageal squamous cell carcinoma and zinc finger protein, which is applied in the field of biomedicine

Inactive Publication Date: 2019-04-19
SHANXI MEDICAL UNIV
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  • Application of zinc finger protein 750 gene in preparing diagnosis reagent for esophageal squamous cell carcinoma
  • Application of zinc finger protein 750 gene in preparing diagnosis reagent for esophageal squamous cell carcinoma
  • Application of zinc finger protein 750 gene in preparing diagnosis reagent for esophageal squamous cell carcinoma

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[0013] The present invention will be further described below through specific embodiments in conjunction with the accompanying drawings, but the present invention is not limited.

[0014] 1. Materials and methods

[0015] Case data and specimen collection 612 cases of esophageal squamous cell carcinoma were collected from patients with esophageal squamous cell carcinoma who were admitted to the Breast Department of Shanxi Cancer Hospital from May 1995 to May 2004. All specimens were obtained with the informed consent of the patients. All patients had no preoperative chemotherapy. All cases were independently diagnosed by 3 pathologists, and the pathological types were all esophageal squamous cell carcinoma (WHO classification). The follow-up time ranged from 36 to 100 months, and 180 patients were followed up for more than 3 years, of which 132 patients were followed up for more than 5 years, with a median follow-up time of 62 months; 4 cases relapsed and 39 cases developed d...

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Abstract

The invention belongs to the technical field of biological medicines, and provides an application of a zinc finger protein 750 gene in preparing a diagnosis reagent for esophageal squamous cell carcinoma, and the application solves the technical problems that in the prior art, the molecular targets of diagnosis and prognosis information of patients with esophageal squamous cell carcinoma are veryfew, and the judgment standards are different. ZNF750 gene coding region mutation and gene copy number deletion are used as molecular markers for diagnosing esophageal squamous cell carcinoma patients. The invention provides an application of the zinc finger protein 750 gene in preparing a prognostic reagent for evaluating the prognosis of the patient with the esophageal squamous cell carcinoma, and the ZNF750 coding region mutation and the gene copy number deletion are used as molecular markers for predicting the prognosis of the patient with the esophageal squamous cell carcinoma. The ZNF750mutation and the copy number deletion esophageal squamous cell carcinoma patients are judged to have poor clinical prognosis, and the esophageal squamous cell carcinoma patients without ZNF750 mutation or copy number are judged to have good clinical prognosis.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of zinc finger protein 750 gene in preparing diagnostic reagents for esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is a common malignant tumor in humans. About 50% of esophageal cancers in the world occur in China. The histological type is mainly esophageal squamous cell carcinoma (ESCC). In my country, there are about 478,000 new cases of esophageal squamous cell carcinoma each year, and about 75,000 deaths. The morbidity and mortality rank the third and fourth among all malignant tumors respectively. Taihang Mountains and Fujian and Guangdong areas. Due to the lack of specific indicators for early clinical diagnosis and effective treatment methods, the overall treatment of esophageal squamous cell carcinoma has not been significantly improved, and the clinical prognosis is extremely poor. The overall 5-year survival ...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/156
Inventor 崔永萍孔鹏洲毕炀辉张玲阎婷崔鹤洋杨健成晓龙马燕春钱钰
Owner SHANXI MEDICAL UNIV
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