Tumor genome copy number variation characteristic pattern recognition method and application thereof
A copy number variation and characteristic pattern technology, applied in the field of tumor genome copy number variation characteristic pattern recognition, can solve the problem of lack of practical tools
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[0057] The method for recognizing the pattern of the copy number variation characteristic of the prostate cancer genome comprises the following steps:
[0058] 1) The high-throughput Whole Exome Sequencing (WES) results of the prostate cancer genome were extracted from the dbGap public database, with a total of 937 pairs of tumor and normal control tissues;
[0059] 2) Using Sequenza software, extract the absolute copy number information of each tumor sample from the above WES sequencing results;
[0060] 3) Record the value of the copy number variation feature, the identification process of the copy number variation feature is as follows figure 1 shown. Eight types of copy number variation signatures were calculated for each tumor: the number of breakpoints per 10Mb (named BP10MB); the number of breakpoints per chromosome arm (named BPArm); the absolute copy number of DNA fragments (named CN); Copy number difference between DNA fragments (called CNCP); length of oscillating...
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