Tumor molecular probe for targeting cervical cancer and application thereof

A molecular probe and tumor technology, applied in the field of biomedicine, can solve the problems of drug treatment failure and tumor resistance, and achieve the effects of high radioactive specific activity, high labeling rate, and high radiochemical purity
CN112999370AActive Publication Date: 2021-06-22PEKING UNIV FIRST HOSPITAL
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV FIRST HOSPITAL
Publication Date
2021-06-22

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Abstract

The invention discloses a tumor molecular probe for targeting cervical cancer and application of the tumor molecular probe. The invention provides a method for preparing the tumor molecular probe, which comprises the following step: performing 99mTc labeling on MAG3 modified Pep-1 polypeptide to obtain the tumor molecular probe. According to the 99mTc-MAG3-Pep-1 probe synthesized and prepared according to the invention, the 99mTc-MAG3-Pep-1 probe has very strong in-vitro stability through detection, and in addition, the invention also explores the development application value of the probe on a subcutaneous tumor-bearing (cervical cancer) mouse model so as to better reveal the biological performance and potential application prospect of the molecular probe. The 99mTc-MAG3-Pep-1 molecular probe with high labeling rate, high radioactivity specific activity and high radiochemical purity is prepared from three aspects of nuclear medicine, basic medicine and clinical transformation, and a good foundation is laid for further animal experiment research and clinical transformation.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a tumor molecular probe targeting cervical cancer and its application. Background technique

[0002] Malignant tumor is a kind of disease affected by multiple factors, multiple gene changes and multi-stage progression, which seriously threatens human life, health and quality of life. Therefore, the study of changes in the tumor microenvironment has always been the focus and focus of oncology research. Small molecule peptides have the advantages of small molecular weight, clear chemical structure, controllable sequence, high activity, and low toxicity, and have long been concerned and favored by materials science and pharmacy. In recent years, in the field of molecular tumor and imaging research, peptides have gradually been widely used in research strategies for diagnosis and disease treatment because of their good assembly properties. At the same time, related transformation results ...

Claims

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