Stable aqueous composition comprising oligosaccharides

A composition and oligosaccharide technology, which can be applied in the directions of drug combination, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as being unsuitable for administration to infants

Pending Publication Date: 2021-07-23
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] For example, a too acidic pH of an aqueous composition would be unsuitable for administration to infants

Method used

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  • Stable aqueous composition comprising oligosaccharides
  • Stable aqueous composition comprising oligosaccharides
  • Stable aqueous composition comprising oligosaccharides

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Embodiment approach

[0051] Oligosaccharides

[0052] In one embodiment, the aqueous composition according to the invention comprises two or more oligosaccharides having a glucose unit at the reducing end.

[0053] In one embodiment, the aqueous composition according to the invention comprises two oligosaccharides having a glucose unit at the reducing end.

[0054] In one embodiment, the aqueous composition according to the invention comprises three oligosaccharides having a glucose unit at the reducing end.

[0055] In one embodiment, the aqueous composition according to the invention comprises five oligosaccharides having a glucose unit at the reducing end.

[0056] In one embodiment, the aqueous composition according to the invention comprises six oligosaccharides having a glucose unit at the reducing end.

[0057] In one embodiment, the aqueous composition according to the invention comprises seven oligosaccharides having a glucose unit at the reducing end.

[0058] In one embodiment, in ...

Embodiment 1

[0164] The oligosaccharides 2'fucosyllactose (2'FL) and lactose-N-neotetraose (LNnT) were mixed in a 2:1 ratio (w / w) and dissolved in water to 10% (w / v) final concentration. The solution was acidified to pH 6 with citric acid and subjected to heat treatment (UHT) before aseptically filling small single-dose vials. The solutions were analyzed before and after filling the vials and after storage at 37°C for various times (accelerated storage conditions).

[0165] Analysis was performed by HPLC using a TSK Gel Amide-80 (150 mm×4.6 mm, particle size: 3 μm) column and detected via a charged aerosol detector. The relative response of the oligosaccharides to the standard curve was quantified using the added fructose isomers of 2'FL and LNnT and their degradation products (fucose, lactose and lacto-N-triose). Fucose, lactose, 2FL, LNnT, 2'-fucosyl-lactulose and LNnT fructose isomers were used as standards. The lactose-N-triose content was calculated using the calibration curve of L...

Embodiment 2

[0168] The oligosaccharides 2'fucosyllactose (2'FL) and lactose-N-neotetraose (LNnT) were mixed in a 10:1 ratio (w / w) and dissolved in water to 10% (w / v) final concentration. From this solution, three samples were generated with pH 6 and pH 7 respectively (by addition of KOH). Such samples were subjected to heat treatment (UHT) before aseptically filling small single-dose vials. The solutions at different pH were analyzed before and after filling the vials and after storage at room temperature (21-26° C.) for various times. Analysis was performed by HPLC using a TSK Gel Amide-80 (150 mm×4.6 mm, particle size: 3 μm) column and detected via a charged aerosol detector. F or 2'FL (Fig. 2a), LNnT (Fig. 2d), the added fructose isomer of 2'FL (indicated as FL lactulose in the figure, Fig. 2d) and the added fructose isomer of LNnT (in The LNnT isomers, Fig. 2e) and their degradation products (lactose, Fig. 2c) are indicated in the figure. The pH of the solution was also measured. ...

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Abstract

The present invention concerns a stable aqueous composition comprising oligosaccharides having a glucose unit at the reducing end and characterised in that the pH of such aqueous composition ranges from 5.5 to 6.5.5.

Description

technical field [0001] The present invention relates to stable aqueous compositions comprising oligosaccharides having glucose units at the reducing end and characterized in that such aqueous compositions have a pH in the range of 5.5 to 6.5 (eg 5.8 to 6.3). The present invention also relates to such aqueous compositions as milk fortifiers for infants, in particular infants born by caesarean section, premature infants, or infants who are small for gestational age and / or infants with low or very low birth weight (LWB or VLBW) or supplement use. The present invention also relates to a method for preventing isomerization of glucose units at the reducing ends of such oligosaccharides in aqueous compositions during heat treatment. Background technique [0002] Breastfeeding is recommended for all infants. However, in some cases, breastfeeding is not sufficient or successful for medical reasons, or the mother does not choose to breastfeed. Infant formulas have been developed fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/21A61K31/702A23L29/30A61P1/00A61P1/12
CPCA23L29/30A23L33/125A23L33/21A23V2002/00A61K31/702A23V2200/06A23V2200/212A23V2200/32A23V2200/3202A61K9/08
Inventor M·马尔佐拉特N·斯普伦格
Owner SOC DES PROD NESTLE SA
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