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Apparatus and method for perfusion culture

一种培养基、用过的技术，应用在生物化学设备和方法、组织细胞/病毒的培养装置、特定用途的生物反应器/发酵罐等方向，能够解决复杂、昂贵、难操作等问题

Pending Publication Date: 2021-07-23
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing systems require the use of some type of reaction control logic to ensure that equal volumes of media are added and removed from the bioreactor vessel at the same time, making the system overall more expensive than other systems employing different culture techniques. more complex and difficult to operate

Method used

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  • Apparatus and method for perfusion culture
  • Apparatus and method for perfusion culture
  • Apparatus and method for perfusion culture

Examples

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Embodiment Construction

[0019] Reference will now be made in detail to the exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference characters are used throughout the drawings to refer to the same or like parts.

[0020] As used herein, "fluid coupled" or "fluid communication" means that components of a system are capable of receiving or transferring fluid between the components. The term fluid includes gases, liquids or combinations thereof. As used herein, "operably coupled" means a connection that may be direct or indirect. A connection is not necessarily a mechanical attachment. As used herein, "weir" means a wall that extends upwardly from the bottom surface of the bioreactor vessel, but does not extend all the way to the top surface of the bioreactor vessel, such that fluid is allowed to flow through or overflow the weir top edge of the . The term "overflow" is used herein to refer to any structure that all...

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Abstract

A bioreactor vessel incudes a first compartment configured to receive a suspension comprising cells and a cell culture medium, for use in a cell processing operation, a second compartment for receiving an overflow of the cell culture medium from the first compartment, and an overflow separating the first compartment from the second compartment, the overflow being configured to maintain a level of the cell culture medium in the first compartment.

Description

technical field [0001] Embodiments of the invention relate generally to bioprocessing apparatus, systems, and methods, and more particularly to a bioreactor vessel and a method of perfusion for a bioreactor vessel. Background technique [0002] Various vessels, devices, components and unit operations are known for performing biochemical and / or biological processes and / or manipulating liquids and other products of such processes. Such biological processes can be used, for example, in the manufacture of cellular immunotherapies such as chimeric antigen receptor (CAR) T cell therapy, which redirects a patient's T cells to specifically target and destroy tumor cells. As is known in the art, the manufacture of cellular immunotherapy, such as CAR T cell therapy, may involve the extraction, activation, genetic modification, culture and expansion of cells in one or more bioreactor vessels. [0003] Recent advances in the manufacture of cellular immunotherapies have provided for the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/34
CPCC12M29/10C12M23/34C12M41/44C12M3/00
Inventor M·蒂明斯
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC
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