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Animal models, screening methods, and treatment methods for intraocular diseases or disorders

A screening method and animal technology, applied in the field of diagnosis and treatment of eye diseases, can solve the problems of unclear environmental factors of soft drusen

Pending Publication Date: 2021-08-06
ZHUHAI QLWEL BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Environmental factors that trigger local inflammation and lead to early soft drusen in AMD pathology are currently unknown

Method used

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  • Animal models, screening methods, and treatment methods for intraocular diseases or disorders
  • Animal models, screening methods, and treatment methods for intraocular diseases or disorders
  • Animal models, screening methods, and treatment methods for intraocular diseases or disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0474] Embodiment 1. A method for modeling an intraocular disease or condition comprising infecting a model vehicle with a microorganism.

Embodiment approach 2

[0475] Embodiment 2. The method of embodiment 1, wherein the microorganism comprises bacteria, archaea, protists, fungi, viruses, or combinations thereof.

Embodiment approach 3

[0476] Embodiment 3. The method of embodiment 1, wherein the model vector comprises a human, a non-human mammal, an organ, a tissue, a tissue section, a tissue extract, a body fluid, a culture of a body fluid, a cell, a virus, an enzyme, a culture one or more of the bases.

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Abstract

Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds / compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds / compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.

Description

[0001] Cross References to Related Applications [0002] This application requires the International Application No. PCT / CN2019 / 070572 filed on January 7, 2019 and the International Application No. PCT / CN2019 / 084369 filed on April 25, 2019 and the Chinese Patent Application No. 201811351660.9 filed on November 14, 2018 The disclosure of each of these patents is incorporated by reference in its entirety for all purposes. technical field [0003] The present invention generally belongs to the technical field of diagnosis and treatment of eye diseases, and more particularly relates to screening methods, animal models and methods of treating or preventing eye diseases or disorders. In various embodiments, the present disclosure also relates to compounds, compositions for treating and / or preventing age-related macular degeneration (AMD) in a subject, such as a human patient or a vertebrate such as a dog, cat, horse or monkey and methods. Background technique [0004] Eyes are t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61K49/00A61P31/00A61P27/02
CPCA61P31/00A61P27/02C12Q1/18G01N2800/16A61K49/0008A61K31/12A61K31/4745A61K31/085A61K31/216A61K31/7034C12Q1/025A01K67/027A61P31/04A61K31/437A61K31/05A61K31/704A01K2267/035A01K2207/10A01K2267/0393A01K2227/106C12R2001/40C12R2001/11A01K67/00A01K2267/03A61K31/235C12N1/20G01N33/5044
Inventor 张岩魏来欧阳晖
Owner ZHUHAI QLWEL BIO TECH LTD