Multi-omic search engine for integrative analysis of cancer genomic and clinical data

A technology of genomics and omics data, applied in medical data mining, special data processing applications, informatics, etc., can solve the problem of not hosting individual user data

Pending Publication Date: 2021-08-06
HUMAN LONGEVITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, most portals do not host individual user data

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  • Multi-omic search engine for integrative analysis of cancer genomic and clinical data
  • Multi-omic search engine for integrative analysis of cancer genomic and clinical data
  • Multi-omic search engine for integrative analysis of cancer genomic and clinical data

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Embodiment Construction

[0032] This specification describes various exemplary embodiments of a multi-omics search engine for integrated analysis of cancer genomic and clinical data, and systems and methods associated therewith. However, the present disclosure is not limited to these exemplary embodiments and applications, nor to the manner in which the exemplary embodiments and applications operate or are described herein.

[0033] Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the embodiments disclosed herein belong. As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Any reference herein to "or" is intended to encompass "and / or" unless stated otherwise.

[0034] This disclosure describes systems and methods for operating a multi-omics search engine for comprehensive analysis of cancer ...

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Abstract

A method is provided for utilizing multi-omic data indices for tumor profiling. The method can comprise the steps of storing a plurality of multi-omic data indices, wherein each of the plurality of multi-omic data indices comprises cancer-specific tokenized data; ingesting additional multi-omic data and any annotations associated with the additional multi-omic data, the additional multi-omic data related to one or more indices; indexing the ingested additional multi-omic data and annotations while preserving gene names, gene variant names and multi-omic mapping between different data streams for the same patient in the specific index, to produce tokenized ingested additional multi-omic data; receiving a user query; selecting one or more relevant multi-omic data indices based on the user query; ranking the selected one or more multi-omic data indices based on at least one of clinical actionability, pathogenicity, feature weight, or frequency; and returning the ranked one or more multi-omic data indices to the user.

Description

Background technique [0001] With the growing importance of cancer genome sequencing, thousands of cancer genomes, exomes, transcriptomes, proteomes, and other cancer data have been collected by private and public institutions (e.g., The Cancer Genome Atlas [TCGA], International The Cancer Genome Consortium [ICGC]) both were sequenced. Interpretation and analysis of tumor and normal sequencing data depends on the comprehensive analysis of both private and public genomic data and databases. [0002] Industry, biopharmaceutical companies, research institutions and the International Cancer Society face obstacles such as (1) providing immediate access to any sample or subset of samples; (2) integrating multi-omics datasets to form a complete picture of tumor biology and (3) efficiently correlate prognostic, diagnostic, and therapeutic information with all available data (e.g., genomic, transcriptomic, proteomic, functional, medical, imaging, literature data) to provide targeted C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B40/20G16H50/20
CPCG16H50/20G16B40/20Y02A90/10G16H70/60G16H50/70G16H30/40G06F16/2272G06F16/24578G06N3/08
Inventor A·哈雷E·辛布洛特C·劳
Owner HUMAN LONGEVITY
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