Preparation method of amide

A technology of amides and compound amides, which is applied in the field of amides preparation, can solve the problems of large toxic chemical substances or by-products, and achieve the effects of wide application of substrates, cost reduction, and good development prospects
CN113292443BActive Publication Date: 2022-07-19CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Publication Date
2022-07-19

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Abstract

The invention relates to a method for preparing an amide. Under the action of oxygen, isothiocyanate and aldehyde can react to form an amide. The effective yield can be obtained only when the reaction temperature is not less than 110°C. This method is also applicable to the reaction of isocyanates and aldehydes to form amides. The preparation method has cheap raw materials, wide substrate applicability, no metal catalyst, initiator or other activator in the reaction process, is green and economical, and can effectively reduce costs.
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Description

technical field

[0001] The invention relates to the technical field of chemical synthesis, in particular to a preparation method of an amide. Background technique

[0002] Amide compounds are recognized as one of the most functional chemical bonds in the field of organic synthesis. They are widely found in a series of natural products, medicines, agricultural chemicals, polymers and functional materials. They are the basic components of peptide bonds in proteins. The synthesis of amides is of great significance in both medicinal chemistry and materials chemistry.

[0003] Traditional methods of amide synthesis are based on the coupling of amines with carboxylic acids, or the activation of carboxylic acids by converting -OH into a good leaving group (eg, acidic chloride, anhydride). However, these methods typically employ stoichiometric coupling agents and additives, resulting in large amounts of toxic chemicals or by-products. Or an oxidation process to synthesize N-pyridi...

Claims

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