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Application of ensrnot00000084277 in the preparation of drugs for the prevention and treatment of chronic pain-related depression

A technology for chronic pain and drugs, which is applied in the field of preparation of drugs for the prevention and treatment of depression related to chronic pain. It can solve the problems of affecting the quality of life of patients, having no treatment means, and aggravating the pain feeling, so as to achieve the effect of improving depression-like behaviors.

Active Publication Date: 2022-06-24
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More and more studies have shown that long-term chronic pain can lead to negative emotions such as anxiety, depression, and disgust, and these negative emotions are far more serious than the pain caused by the pain itself, and the long-term existence of negative emotions is still difficult. Can aggravate the feeling of pain and seriously affect the patient's quality of life
Depression is one of the common negative emotions associated with chronic pain, but there is currently no clinically effective treatment for chronic pain-related depression

Method used

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  • Application of ensrnot00000084277 in the preparation of drugs for the prevention and treatment of chronic pain-related depression
  • Application of ensrnot00000084277 in the preparation of drugs for the prevention and treatment of chronic pain-related depression
  • Application of ensrnot00000084277 in the preparation of drugs for the prevention and treatment of chronic pain-related depression

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Experimental program
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Embodiment 1

[0026] 1. Main experimental methods:

[0027] (1) Experimental animals: Healthy male SPF SD rats were provided by the Experimental Animal Center of Xuzhou Medical University, weighing 200-220 g.

[0028] (2) Preparation of neuropathic pain model: SD rats were randomly divided into sham operation group (Sham) and SNI model group. In the SNI model group, the neuropathic pain model was established by selective sciatic nerve branch injury. The skin was incised along the outer depression of the femur on the left thigh of the rat, and a long incision of about 1-2 cm was made. The surrounding tissue was bluntly separated to expose the three branches of the rat sciatic nerve, and the sural nerve was preserved. tibial and common peroneal nerves. The incision was sutured with 4.0 silk suture. Rats in the Sham group only exposed the sciatic nerve without ligation. All experiments were performed in strict compliance with aseptic principles.

[0029](3) Determination of mechanically s...

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Abstract

The present invention relates to the application of ENSRNOT00000084277 in the preparation of drugs for preventing and treating depression related to chronic pain, which proves the important role of ENSRNOT00000084277 in the formation of depression related to chronic pain, and up-regulating ENSRNOT00000084277 can significantly improve the depression-like behavior of rats with chronic pain. Therefore, ENSRNOT00000084277 can be used as a molecular target to prepare drugs for the prevention and treatment of chronic pain-related depression, which provides a new idea for the research and development of depression prevention and treatment drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of ENSRNOT00000084277 in the preparation of a drug for the prevention and treatment of chronic pain-related depression. Background technique [0002] Chronic pain has always been one of the important health concerns worldwide. More and more studies have shown that long-term chronic pain can lead to negative emotions such as anxiety, depression, disgust, etc., and these negative emotions are far more serious than the pain caused by the pain itself, and the long-term existence of negative emotions also It can aggravate the feeling of pain and seriously affect the patient's quality of life. Depression is one of the common chronic pain-related negative emotions, but there is currently no effective clinical treatment for chronic pain-related depression. Therefore, it is of great practical significance and urgency to study the mechanism of chronic pain-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7088A61K47/46A61K45/00A61P25/24A61P25/04
CPCA61K45/00A61K31/7088A61K47/46A61P25/24A61P25/04
Inventor 周成华武玉清王瑞瑶焦晓薇丁小宝林玉文
Owner XUZHOU MEDICAL UNIV
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