Application of shrimp head zymolyte in regulating generation of intestinal short-chain fatty acid and improving depression-like behavior

Abstract

The invention belongs to the technical field of functional marine product application, and discloses application of shrimp head zymolyte in the aspects of regulating intestinal short-chain fatty acid and improving depression-like behaviors, chronic stress depression model mice are constructed, the influence of the shrimp head zymolyte on the intestinal short-chain fatty acid is investigated, and the depression-like behaviors of the intestinal short-chain fatty acid are improved. Results show that after the shrimp head peptide intervention, the despair state time of the mouse is obviously reduced, the exploration desire of the mouse to an open space and a high-altitude environment is obviously increased, and the behavioral performance is recovered to a normal level, namely, the depression-like behavior of the mouse is obviously improved. The intervention effect is better than that of a fish oil group; the content of 5-hydroxytryptamine in the low-dose group and the medium-dose group is increased, and the content of dopamine in the low-dose group is increased; after intragastric administration of shrimp head peptide, acetic acid, propionic acid and n-butyric acid can be significantly regulated to recover normal levels; the depression-like behavior of the mouse is further improved; the research result provides a theoretical basis for developing the shrimp head zymolyte into a new generation of green and safe anti-depression food.

Description

technical field [0001] The invention belongs to the technical field of functional seafood applications, and more specifically relates to the application of shrimp head enzymatic hydrolyzate in regulating intestinal short-chain fatty acid levels and improving depression-like behaviors. Background technique [0002] Depression is a depressive disorder characterized by significant and persistent low mood. Clinically, low mood, stupor, and lack of desire for survival can be seen. Serum 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT) content decreased significantly during the onset of the disease, accompanied by brain inflammation. According to the 2017 survey report of WHO, in the past 10 years, the number of patients with depression worldwide has increased by more than 18%, and as of 2015, it has exceeded 300 million. It is speculated that by 2030, depression will become one of the top contributors to the human disease burden. [0003] At present, the treatment of depression ...

AI Technical Summary

Problems solved by technology

[0004] Shrimp head is the leftovers in the process of shrimp processing. It is generally used to make feed and fertilizer, but the processing rate is low.

A large number of shrimp heads are still discarded every year, and there is no research report on the use of shrimp heads in the treatment of depression

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