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Application of ENSRNOT00000084277 in preparation of medicine for preventing and treating chronic pain related depressive emotion

A chronic pain and drug technology, applied in the field of preparation of drugs for the prevention and treatment of chronic pain-related depression, can solve the problems of affecting the quality of life of patients, having no treatment means, aggravating pain sensation, etc., and achieve the effect of improving depression-like behaviors

Active Publication Date: 2021-08-27
XUZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

More and more studies have shown that long-term chronic pain can lead to negative emotions such as anxiety, depression, and disgust, and these negative emotions are far more serious than the pain caused by the pain itself, and the long-term existence of negative emotions is still difficult. Can aggravate the feeling of pain and seriously affect the patient's quality of life
Depression is one of the common negative emotions associated with chronic pain, but there is currently no clinically effective treatment for chronic pain-related depression

Method used

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  • Application of ENSRNOT00000084277 in preparation of medicine for preventing and treating chronic pain related depressive emotion
  • Application of ENSRNOT00000084277 in preparation of medicine for preventing and treating chronic pain related depressive emotion
  • Application of ENSRNOT00000084277 in preparation of medicine for preventing and treating chronic pain related depressive emotion

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Experimental program
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Embodiment 1

[0026] 1. Main experimental methods:

[0027] (1) Experimental animals: healthy male SPF grade SD rats were provided by the Experimental Animal Center of Xuzhou Medical University, weighing 200-220 g.

[0028] (2) Preparation of neuropathic pain model: SD rats were randomly divided into sham operation group (Sham) and SNI model group. In the SNI model group, the neuropathic pain model was established by selective sciatic nerve branch injury, and the specific operation was as follows: After the rats were anesthetized by intraperitoneal injection of 10% chloral hydrate (35 mg / kg), they were fixed on the experimental console in a prone position. Cut the skin along the outer depression of the femur on the left thigh of the rat, make an incision about 1-2 cm long, bluntly separate the surrounding tissues to expose the three branches of the rat sciatic nerve, keep the sural nerve, use chrome catgut to ligate and cut off tibial nerve and common peroneal nerve. The incision was clos...

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Abstract

The invention relates to an application of ENSRNOT00000084277 in the preparation of a medicine for preventing and treating chronic pain related depressive mood. It is proved that the ENSRNOT00000084277 plays an important role in formation of the chronic pain related depressive mood, and the depression-like behavior of a rat with chronic pain can be obviously improved by up-regulating the ENSRNOT00000084277. Therefore, the ENSRNOT00000084277 can be used as a molecular target for preparing the medicine for preventing and treating the depression related to the chronic pain, and a new thought is provided for research and development of the depression prevention and treatment medicine.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of ENSRNOT00000084277 in the preparation of chronic pain-related depression prevention and treatment drugs. Background technique [0002] Chronic pain has been one of the major health concerns worldwide. More and more studies have shown that long-term chronic pain can lead to negative emotions such as anxiety, depression, and disgust, and these negative emotions are far more serious than the pain caused by the pain itself, and the long-term existence of negative emotions is still difficult. It can aggravate the feeling of pain and seriously affect the patient's quality of life. Depression is one of the common negative emotions associated with chronic pain, but there is currently no effective clinical treatment for chronic pain-related depression. Therefore, it is of great practical significance and urgency to study the mechanism of the formation o...

Claims

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Application Information

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IPC IPC(8): A61K31/7088A61K47/46A61K45/00A61P25/24A61P25/04
CPCA61K45/00A61K31/7088A61K47/46A61P25/24A61P25/04
Inventor 周成华武玉清王瑞瑶焦晓薇丁小宝林玉文
Owner XUZHOU MEDICAL UNIV
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