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Preparation method of Li medicine callicarpa nudiflora scald ointment

A technology of naked flower purple beads and scald ointment, which is applied in the field of medicine and achieves the effects of stable performance, favorable promotion, and scientific and reasonable component ratio.

Inactive Publication Date: 2021-08-31
HAINAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the preparation of Li medicine nude flower purple pearl into scald ointment

Method used

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  • Preparation method of Li medicine callicarpa nudiflora scald ointment
  • Preparation method of Li medicine callicarpa nudiflora scald ointment
  • Preparation method of Li medicine callicarpa nudiflora scald ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A kind of preparation method of Li medicine Nudehuazizhu scald ointment, it is characterized in that, it comprises the following steps:

[0054] (1) Extraction of the herbal medicinal material:

[0055] Take the purple pearl medicinal material, add water of 12, 10, and 10 times the weight of the medicinal material respectively, soak for 2 hours, then reflux extraction, extract for 1 hour each time, filter, combine the water extracts for 3 times, and concentrate to obtain the purple pearl medicinal material. paste;

[0056] (2) Preparation of scald ointment

[0057]Using the emulsification method, the w / o nude flower purple pearl scald ointment was prepared. First, the oil phase raw materials were taken and the oil phase raw materials were composed of polysorbate-80 1.2g, glycerol monostearate 4.7g and glycerin 0.9g and heated to 70°C. Then slowly add 10.8g of liquid paraffin, 1.4g of sorbitan oleate, 1.4g of solid paraffin and 0.9g of petrolatum, which have been heate...

Embodiment 2

[0058] Example 2 Nudehuazizhu scald ointment pharmacodynamic experiment

[0059] 1. Experimental principle

[0060] ①Scald wounds will be affected by drugs, which will change the degree or speed of wound healing. During the healing process, there will be changes visible to the naked eye (such as: wound size, color, degree of hardness, scabbing, etc.).

[0061] ② During the healing process of burn wounds, the contents of some cytokines (TNF, IL, TGF, VEGF, etc.) in the body will change. According to the change of its content, the mechanism of action of the drug is explored.

[0062] 2. Experimental method

[0063] ① SD rat scald modeling: 30 SD rats (240±10g) were randomly divided into 3 groups, 10 in each group, that is, Deep II 0 Scald experimental group (Nude Flower Purple Pearl scald ointment group prepared in Example 1), Deep II 0 Scald blank control group (matrix group without Nudehuazizhu extract), deep II 0 Burn negative control group (blank group). Sodium sulfide...

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Abstract

The invention discloses a preparation method of a Li medicine callicarpa nudiflora scald ointment. The method comprises the following steps: taking a callicarpa nudiflora medicinal material, respectively adding water which is 12, 10 and 10 times of the weight of the medicinal material, soaking for 2 hours, then performing reflux extraction for 1 hour each time, filtering, combining water extracts of three times, and concentrating to obtain a callicarpa nudiflora medicinal material extract; and preparing the w / o callicarpa nudiflora scald ointment by an emulsion process: firstly, taking oil-phase raw materials including polysorbate-80, glyceryl monostearate and glycerol, heating to 70-80 DEG C, then slowly adding the oil-phase raw materials into water-phase raw materials including liquid paraffin, sorbitan oleate, solid paraffin and vaseline which are heated to 70-80 DEG C, adding the callicarpa nudiflora medicinal material fluid extract while stirring, emulsifying and condensing for 20-30 minutes, and obtaining the Li medicine callicarpa nudiflora scald ointment. The raw materials are optimized through a large number of experiments, and the prepared Li medicine callicarpa nudiflora scald ointment is scientific and reasonable in component proportion, stable in performance, capable of well promoting wound healing, reliable in curative effect and good in safety.

Description

[0001] This application is a divisional application with an application date of November 07, 2016, an application number of 201610971201.5, and an invention title of "A Preparation Method for Li Medicine Naked Flower Zizhu Scald Ointment". technical field [0002] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of Li medicine Nudehuazizhu scald ointment. Background technique [0003] Callicarpanudiflora (Callicarpanudiflora Hook.exArn.) is a small perennial tree belonging to the Verbenaceae family, also known as Dafengye. It is distributed in central and southern Hainan at an altitude of more than 300m, with an annual rainfall of 1000-1800mm, beside mountain roads, valleys, and streams in vast mountainous areas. On the edge or in the bushes, it grows well in an environment with an average annual temperature of 15-25°C. It is a bulk authentic medicinal material in Hainan, and it is also one of the commonly used medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/06A61P17/02
CPCA61K47/26A61K9/0014A61K9/06A61K36/85A61K2236/51A61K2236/331A61P17/02A61K2236/39
Inventor 谭银丰李海龙张仲秦贞苗张俊清周金娜邱梦婕周小芳黄明浩罗贤强
Owner HAINAN MEDICAL UNIV
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