Magnetic resonance nano probe and preparation method and application thereof
A nano-probe and magnetic resonance technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, nanotechnology, inorganic non-effective ingredients, etc., can solve the problems of poor tumor MR imaging, easy accumulation in normal parts, and low signal-to-noise ratio , to achieve high drug loading, significantly high specific tumor imaging, and high resolution effects
Inactive Publication Date: 2021-09-07
ZHENGZHOU UNIV
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Problems solved by technology
[0006] One of the objects of the present invention is to provide a magnetic resonance nanoprobe, the second object is to provide a method for preparing a magnetic resonance nanoprobe, and the third object is to provide an application of a magnetic resonance nanoprobe to solve the current The clinically used contrast agent is "always on", which makes MR imaging of tumors in vivo poor, low signal-to-noise ratio, low sensitivity, and easy to accumulate in normal parts
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Embodiment 1
[0043] A method for preparing a magnetic resonance nanoprobe, comprising the following steps:
[0044] 1) Hollow mesoporous iron oxide nanoparticles (HMIN) were prepared by a one-pot hydrothermal method: 811 mg FeCl 3 ·6H 2 O, 1760 mg sodium citrate and 541 mg urea were dissolved in 60 mL distilled water and 300 mg PAM was added; the solution was transferred to an 80 mL Teflon-lined autoclave and incubated at 200 °C for 12 h; the black precipitate was collected using an external magnet Then, the precipitate was washed several times with distilled water and ethanol, and dried overnight in a vacuum oven at 40°C to obtain HMIN;
[0045] 2) Disperse 100 mg of HMIN prepared in step 1) into 40 mL of deionized water to obtain a uniform HMIN aqueous dispersion; disperse 1000 mg of PEI with a MW of 600 into 20 mL of deionized water, then add the HMIN aqueous dispersion and stir at room temperature for 24 hours ; The precipitate produced was separated with an external magnet, and was...
Embodiment 2
[0049] In this example, except that the molecular weight of PEI is replaced with 2000 or 5000, the rest of the experimental conditions are the same as in Example 1.
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Abstract
The invention discloses a magnetic resonance nano probe and a preparation method and application thereof, and relates to the technical field of medicine preparation. The preparation method comprises the steps that ferric oxide and PEI are dispersed into water separately, then a mixed reaction is conducted, separation and precipitation are conducted, washing is conducted, nano composite particles are obtained, the nano composite particles are added into a PBS solution containing GdCl3, methanol is added after ultrasonic treatment, ultrasonic treatment is conducted again, and Gd-loaded hollow mesoporous ferric oxide nano composite particles are obtained; HA, EDC. HCl and NHS are added into formamide, and an activated solution is obtained; and the Gd-loaded hollow mesoporous ferric oxide nano composite particles are added into formamide, the activated solution is added, acetone is added after a reaction, centrifugation and washing are conducted, and the magnetic resonance nano probe is obtained. The special switch type magnetic resonance nano probe which is used for tumor high-resolution imaging and has the distance control characteristic can improve the background ratio and sensitivity of in-vivo tumor MR imaging and imaging targets, and has application and popularization value in the field of tumor imaging.
Description
technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a magnetic resonance nanoprobe and its preparation method and application. Background technique [0002] Ordered mesoporous materials are new nanostructure materials that emerged rapidly in the 1990s. In 1992, Mobil Corporation reported the M41S (Mobile Crystalline Material, MCM) series of mesoporous materials, including MCM-41, MCM-48, MCM-50, As soon as it was born, it has been highly valued by the international physics, chemistry and materials science circles, and has rapidly developed into one of the interdisciplinary research hotspots. Mesoporous materials have the characteristics of extremely high specific surface area, regular and ordered pore structure, narrow pore size distribution, and continuously adjustable pore size. Iron oxides especially Fe 3 o 4 , due to their unique superparamagnetism and good biocompatibility, scientists have long been used as ma...
Claims
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IPC IPC(8): A61K49/08A61K47/02B82Y40/00
CPCA61K49/08A61K47/02B82Y40/00
Inventor刘军杰于文燕史进进张开翔张振中刘卫韩明旭
OwnerZHENGZHOU UNIV