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Preparation method of borneol-triclosan composite antibacterial agent

A compound antibacterial agent, triclosan technology, applied in the field of preparation of borneol-triclosan compound high-efficiency antibacterial agent, can solve the problems of complex synthesis steps, immature technical system, high cost, etc., and achieve simple product structure and high-efficiency sterilization Antibacterial and low energy consumption

Active Publication Date: 2021-09-17
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Composite antibacterial agents have many advantages, but the current technical system is immature, the synthesis steps are complicated, and the cost is high

Method used

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  • Preparation method of borneol-triclosan composite antibacterial agent
  • Preparation method of borneol-triclosan composite antibacterial agent
  • Preparation method of borneol-triclosan composite antibacterial agent

Examples

Experimental program
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Embodiment 1

[0027] 1) Activate the 3A potassium molecular sieve at 500°C for 1 hour, then pour tetrahydrofuran into it, dehydrate the tetrahydrofuran overnight, put the tetrahydrofuran into a beaker, and keep it in an ice-water bath for 10-30 minutes to lower the temperature to Around 0℃ for use;

[0028] 2) Dissolve 1g of L-borneol and 0.75g of pyridine in 20mL of treated tetrahydrofuran, and dissolve 0.7g of triclosan in 3.5mL of treated tetrahydrofuran. After stirring for 30min, the obtained triclosan solution was dropped Add it to the borneol-pyridine solution, and react at room temperature for 24 hours;

[0029] 3) Filter the reaction liquid (subject to the fact that no solid impurities can be seen in the filtrate with the naked eye), and obtain a white transparent oil after the filtrate is rotary evaporated;

[0030] 4) Dissolve the obtained oil in 30mL of anhydrous ether, and then wash with 2mol / L hydrochloric acid solution, saturated sodium bicarbonate solution, and saturated sod...

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Abstract

The invention discloses a preparation method of a borneol-triclosan composite antibacterial agent, under the condition of taking pyridine as a catalyst, borneol and triclosan react at a certain temperature to synthesize the composite antibacterial agent. An antibacterial experiment proves that the borneol-triclosan composite antibacterial agent has the antibacterial efficiency of 99% or above on gram-positive staphylococcus aureus, gram-negative escherichia coli and pseudomonas aeruginosa, the preparation condition is mild, the preparation raw materials are easy to obtain and are nontoxic and non-irritant, and the antibacterial agent can be widely applied to the fields of sanitation, packaging, medicine, textiles, filter materials, environmental protection and the like.

Description

technical field [0001] The invention belongs to the field of synthesis of pharmaceutical organic small molecules, and in particular relates to a preparation method of a borneol-triclosan compound high-efficiency antibacterial agent. Background technique [0002] Since Leeuwenhoek discovered bacteria, people have paid more and more attention to bacteria, especially bacteria are ubiquitous in modern life. Bacteria can cause a series of diseases such as tetanus, pneumonia, tuberculosis, and cholera, and Bacteria grow in a wide range of environments, such as sewers, garbage dumps, sweaty fabrics, food, untreated water, etc. There are many bacteria even in the air, which is hard to guard against. Because the ubiquitous bacteria have brought great troubles to people's lives, people are gradually seeking ways to eliminate bacteria. With the continuous advancement of research, antibacterial agents that can effectively resist bacteria appear in people's field of vision. [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/16A01P1/00C07C43/295C07C41/16C07C41/34C07C41/36
CPCA01N31/16C07C41/16C07C41/34C07C41/36C07C2602/42C07C43/295
Inventor 温娜王琪吴志龙李双双杨佳超毛爱姣
Owner FUZHOU UNIV
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