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A kind of preparation method of borneol-triclosan compound antibacterial agent

A technology for compound antibacterial agent and triclosan, which is applied in the field of preparation of borneol-triclosan compound high-efficiency antibacterial agent, can solve the problems of complex synthesis steps, high cost, immature technical system, etc., and achieves simple product structure and low consumption. Low and efficient bactericidal and bacteriostatic effect

Active Publication Date: 2022-06-21
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Composite antibacterial agents have many advantages, but the current technical system is immature, the synthesis steps are complicated, and the cost is high

Method used

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  • A kind of preparation method of borneol-triclosan compound antibacterial agent
  • A kind of preparation method of borneol-triclosan compound antibacterial agent
  • A kind of preparation method of borneol-triclosan compound antibacterial agent

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Embodiment 1

[0027] 1) First activate 3A potassium molecular sieve at 500°C for 1h, then pour into tetrahydrofuran, remove water from tetrahydrofuran overnight, put tetrahydrofuran into a beaker, and then place it in an ice-water bath for 10~30min, so that the temperature drops to about 0℃ for use;

[0028] 2) Dissolve 1 g of L-borneol and 0.75 g of pyridine in 20 mL of treated tetrahydrofuran, and 0.7 g of triclosan in 3.5 mL of treated tetrahydrofuran. After stirring for 30 min, the obtained triclosan solution was added dropwise. added to the borneol-pyridine solution and reacted at room temperature for 24h;

[0029] 3) Filter the reaction solution (the filtrate does not have solid impurities visible to the naked eye), and obtain a white transparent oily substance after the filtrate is rotary evaporated;

[0030] 4) Dissolve the obtained oil in 30 mL of anhydrous ether, wash with 2 mol / L hydrochloric acid solution, saturated sodium bicarbonate solution, and saturated sodium chloride sol...

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Abstract

The invention discloses a preparation method of a borneol-triclosan composite antibacterial agent. Under the condition of using pyridine as a catalyst, the composite antibacterial agent is synthesized by reacting borneol and triclosan at a certain temperature. Proved by antibacterial experiments, the obtained borneol-triclosan composite antibacterial agent of the present invention has an antibacterial efficiency of more than 99% to Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and Pseudomonas aeruginosa, and its The preparation conditions are mild, and the preparation raw materials are easy to obtain, non-toxic and non-irritating, and can be widely used in fields such as hygiene, packaging, medicine, textiles, filter materials, and environmental protection.

Description

technical field [0001] The invention belongs to the field of pharmaceutical organic small molecule synthesis, and in particular relates to a preparation method of a borneol-triclosan composite high-efficiency antibacterial agent. Background technique [0002] Since Leeuwenhoek discovered bacteria, people have paid more and more attention to bacteria, especially in modern life, bacteria are everywhere, and bacteria can cause a series of diseases such as tetanus, pneumonia, tuberculosis, cholera, etc. Bacteria grow in a wide range of environments, such as sewers, garbage dumps, sweaty fabrics, food, untreated water, etc. There are even many bacteria in the air, which are hard to prevent. As the ubiquitous bacteria bring great trouble to people's life, people gradually seek methods to eliminate bacteria. With the continuous progress of research, antibacterial agents that effectively resist bacteria appear in people's field of vision. [0003] Advances in scientific research ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N31/16A01P1/00C07C43/295C07C41/16C07C41/34C07C41/36
CPCA01N31/16C07C41/16C07C41/34C07C41/36C07C2602/42C07C43/295
Inventor 温娜王琪吴志龙李双双杨佳超毛爱姣
Owner FUZHOU UNIV
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