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A kind of oral care composition containing peptide and preparation method thereof

A technique for oral care and composition, which is applied in the field of oral care composition and its preparation, and can solve the problems of less obvious oral bacteria removal effect and poor effect of inhibition of enamel demineralization, etc., achieving good inhibition effect and good removal effect Effect

Active Publication Date: 2021-11-16
THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the removal effect on oral bacteria is not obvious during normal mouthwash at this concentration; and the inhibitory effect on enamel demineralization is not good.

Method used

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  • A kind of oral care composition containing peptide and preparation method thereof
  • A kind of oral care composition containing peptide and preparation method thereof

Examples

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Embodiment 1

[0053] A peptide-containing oral care composition, according to weight percentage, raw materials include:

[0054] Glycerol 15%;

[0055] Sodium Monooleate Macrogol 400 Phosphate 2%;

[0056] Nano-hydroxyapatite (average particle size is 20nm; specific surface area is 50m 2 / g) 2.5%;

[0057] h 4 P 2 o 7 - Arg-Arg-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Phe-Cys-Tyr-Arg-Lys-Cys-Arg; 0.3%;

[0058] Ethanol 4%;

[0059] Polysorbate 80 4%;

[0060] Xylitol 1%;

[0061] Sodium Benzoate 0.1%;

[0062] Fragrance 0.1%;

[0063] Deionized water balance.

[0064] The preparation method comprises the following steps:

[0065] Mix glycerin and ethanol evenly; add polysorbate 80, xylitol, sodium benzoate, essence and 10-20% deionized water (based on the total amount of deionized water); then add antimicrobial peptides, monofatty acid polyethylene glycol Diol phosphate sodium salt is mixed evenly; then add nano-hydroxyapatite and 80-90% deionized water (based on the total amount of...

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Abstract

The invention discloses a peptide-containing oral care composition, which includes antibacterial peptide and nano-hydroxyapatite; and further includes monofatty acid polyethylene glycol phosphate sodium salt. In addition, the present invention also discloses a corresponding preparation method, comprising uniformly mixing the moisturizing agent and ethanol; adding antibacterial peptides, monofatty acid polyethylene glycol phosphate sodium salt; and then adding nano-hydroxyapatite. The composition not only has a better effect of removing oral bacteria, but also has a better effect of inhibiting tooth enamel demineralization.

Description

technical field [0001] The invention belongs to the technical field of oral care, and in particular relates to an oral care composition and a preparation method thereof. The oral care composition includes antimicrobial peptides and nano-hydroxyapatite. Background technique [0002] Among oral diseases, dental caries is a chronic disease of bacterial infection, which easily leads to progressive destruction of dental hard tissues. The pathogenic mechanism of dental caries is: plaque microorganisms adhere to the tooth surface and decompose sugars into acids, thereby causing the decomposition of organic matter and demineralization of inorganic matter. Streptococcus, Lactobacillus, and Actinomycetes are the main genera of caries-causing bacteria. Among them, Streptococcus mutans is recognized as a cariogenic bacterium. It not only ferments sugar to produce a large amount of acid and destroys tooth enamel, but also produces extracellular polysaccharides to promote the formation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/24A61K8/34A61K8/49A61K8/86A61P1/02A61P31/04A61Q11/00
CPCA61K8/64A61K8/24A61K8/86A61K8/345A61K8/34A61K8/4993A61Q11/00A61P1/02A61P31/04A61K2800/413
Inventor 李冰慎玲玉李一佳高晓杰刘焱
Owner THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
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