Preparation method and application of a novel ionic liquid functionalized injectable conductive hydrogel
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A technology of conductive hydrogel and ionic liquid, which is applied in applications, electrotherapy, liquid delivery, etc., can solve the problems of not being able to cover the wound area, human body disadvantages, etc., and achieve excellent antibacterial performance, short gelation time, and excellent adhesive performance Effect
Active Publication Date: 2022-06-17
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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However, current electrode-based ES strategies suffer from some limitations, for example, the applied ES cannot cover the entire wound area, and high-parameter ES applied on large wounds is also unfavorable to the human body (Y.Lu, Y.Wang, J. Zhang, X. Hu, Z. Yang, Y. Guo, Y. Wang, Acta Biomaterialia, 2019, 89: 217-226)
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Embodiment 1
[0064] Embodiment 1 A preparation method of a novel ionic liquid functionalized injectable conductive hydrogel, comprising the following steps:
[0065] (1) Poly PBAimBF 4 Preparation of ionic liquids;
[0066] (a) PBAimBF 4 Preparation of ionic liquid:
[0067] Dissolve 1-(3-aminopropyl)imidazole (7mmol, 0.876g) in acetonitrile, add 0.216g NaH at 0°C, transfer it to an oil bath after the reaction for 3h, and after the temperature rises to 80°C, 1,2-dibromoethylene (3mmol, 0.558g) was added dropwise, and the reaction was magnetically stirred for 24h under the protection of N2. After removal of the solvent by rotary evaporation, the product was dissolved in a small amount of methanol and washed three times with anhydrous ether. Subsequently, the product was added to a saturated aqueous solution of sodium tetrafluoroborate and stirred at room temperature for 2 h. After the reaction was stopped, dichloromethane was extracted several times, and diluted AgNo 3 Solution confirm...
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Abstract
The invention belongs to the technical field of preparation of biomedical materials, and in particular relates to a preparation method and application of a novel ionic liquid functionalized injectable conductive hydrogel. The present invention prepares a bisaminoimidazole tetrafluoroborate ionic liquid containing positively charged active groups: 1,1'-(ethyl-1,2-)-bis-(3-(3-aminopropyl) )-1H imidazolium tetrafluoroborate ionic liquid, after polymerization, mixed with aldehyde-functionalized hyaluronic acid in a mass ratio of 3:(1~4), and through Schiff base reaction, a new type of injectable Type Conductive Hydrogel PIL‑OHA. The hydrogel PIL-OHA prepared by the present invention has excellent antibacterial properties and mechanical properties, and can significantly promote the skin wound healing of diabetic model mice when coupled with exogenous alternating current stimulation.
Description
[Technical field] [0001] The invention belongs to the technical field of biomedical material preparation, and in particular relates to a preparation method and application of a novel ionic liquid functionalized injectable conductive hydrogel. [Background technique] [0002] More than 6.5 million people worldwide suffer from diabetic wounds, and annual healthcare costs exceed US$25 billion (Y.Lu, Y.Wang, J.Zhang, X.Hu, Z.Yang, Y.Guo, Y.Wang, ActaBiomaterial, 2019 , 89:217-226). Current treatments for diabetic wounds include hyperbaric oxygen therapy, negative pressure wound therapy, growth factors, and the application of skin substitutes, but these strategies are costly, time-consuming, and cannot achieve satisfactory results. Treatment faces enormous challenges (Q. Bai, K. Han, K. Dong, C. Zheng, Y. Zhang, Q. Long, T. Lu, International Journal of Nanomedicine, 2020, 15: 9717-9743). Among these strategies, electrical stimulation has attracted more and more researchers' atte...
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