Ruthenium complex nanoscale particle, preparation method and application thereof, and antitumor drug

A technology of anti-tumor drugs and ruthenium complexes, which can be used in anti-tumor drugs, ruthenium organic compounds, drug combinations, etc., can solve the problem that cyclometallic ruthenium complexes cannot be used directly, and achieve good self-assembly function and good conjugation effect. Effect
CN113501848BActive Publication Date: 2022-01-14THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE SEVENTH AFFILIATED HOSPITAL SUN YAT SEN UNIV SHENZHEN
Publication Date
2022-01-14

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Abstract

The invention relates to the technical field of antitumor drugs, and specifically provides a ruthenium complex nanoscale particle, a preparation method and application thereof, and an antitumor drug. The ruthenium complex nano-scale particles are used for nano-medicine, and are self-assembled by the ring metal ruthenium complex; the ring metal ruthenium complex has a general formula as shown in formula I. The ruthenium complex nanometer particle of the invention has antitumor biological activity, and can be used as an active ingredient of an antitumor drug or directly as an antitumor drug.
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Description

technical field

[0001] The invention belongs to the technical field of antitumor drugs, and in particular relates to a ruthenium complex nanoscale particle, a preparation method and application thereof, and an antitumor drug. Background technique

[0002] Cancer is one of the major diseases that kill human beings. At present, chemotherapy drugs are mainly used to treat cancer. However, because most of the current chemotherapy drugs have serious side effects and drug resistance, the treatment effect is not satisfactory. Therefore, it is urgent to develop new types of drugs. Chemotherapy drugs.

[0003] Metal ruthenium complexes have attracted widespread attention because of their good anti-tumor activity. Currently, four cases of metal ruthenium complexes have entered clinical research as anti-tumor agents, and two are in the process of clinical research. Although numerous ruthenium complexes such as Ru1, Ru2, Ru3, Ru4, etc. shown below have been reported to have anti-tumor ...

Claims

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