Mechanism analysis method of traditional Chinese medicine for treating chronic bronchitis
A technology for chronic bronchitis and mechanism analysis, applied in the field of network pharmacology and data mining, it can solve the problems of high recurrence rate and many adverse reactions, and achieve the effect of improving reliability.
Pending Publication Date: 2021-10-15
HANGZHOU DIANZI UNIV
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Problems solved by technology
For chronic bronchitis, Western medicine is often used clinically, because this mode has a quick effect, but it is easy to cause more adverse reactions and has a high recurrence rate. Therefore, it is necessary to find a more effective treatment mode.
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[0044] In order to illustrate the embodiments of the present invention more clearly, the specific implementation manners of the present invention will be described below with reference to the accompanying drawings. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention, and those skilled in the art can obtain other accompanying drawings based on these drawings and obtain other implementations.
[0045] The mechanism analysis method of the treatment chronic bronchitis Chinese medicine of the embodiment of the present invention, comprises the following steps:
[0046] S1. Using chronic bronchitis as a keyword, data mining is performed on the data of traditional Chinese medicine prescriptions to obtain a reasonable combination of traditional Chinese medicines; specifically, the following steps are included:
[0047]S11. From the big data of traditional Chinese medicine prescriptions in the hospital, use chronic bronch...
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The invention relates to a mechanism analysis method of a traditional Chinese medicine for treating chronic bronchitis, which comprises the following steps: S1, performing data mining on traditional Chinese medicine prescription data for chronic bronchitis to obtain a reasonable traditional Chinese medicine composition; S2, obtaining active ingredients of various traditional Chinese medicines of the traditional Chinese medicine composition and related targets of the traditional Chinese medicines; S3, acquiring chronic bronchitis related targets; S4, intersecting the traditional Chinese medicine related target spots with the chronic bronchitis related target spots to obtain common target spots, constructing a PPI network, and screening core target spots; S5, constructing a regulation and control topological network diagram among the traditional Chinese medicines, the active ingredients, the core targets and the diseases so as to display the action paths of the traditional Chinese medicines from the overall level; S6, inputting the chronic bronchitis related target spots into a Metascap database for analysis so as to carry out enrichment analysis; and S7, carrying out molecular docking, and evaluating the binding strength and activity of the target spot and the active component. The reliability and accuracy of traditional Chinese medicine mechanism analysis of chronic bronchitis are improved.
Description
technical field [0001] The invention belongs to the fields of data mining and network pharmacology, and in particular relates to a mechanism analysis method of traditional Chinese medicine for treating chronic bronchitis. Background technique [0002] Traditional Chinese medicine science has accumulated massive prescription data in long-term medical practice, but Chinese medicine prescription is a non-linear, multi-dimensional, complex and huge system, and traditional data analysis methods are difficult to meet modern requirements for informationization of Chinese medicine prescriptions. Due to its adaptability to complex and multi-dimensional systems, data mining technology has become one of the most effective methods for data analysis of traditional Chinese medicine prescriptions. Using data mining technology to discover the knowledge of traditional Chinese medicine contained in these massive data is a A very valuable research work. [0003] At present, in the process of ...
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Login to View More IPC IPC(8): G16B15/30G16B5/00G16B40/00G16B50/00G16B20/00G16H70/40G16H50/70
CPCG16B15/30G16B5/00G16B40/00G16B50/00G16B20/00G16H70/40G16H50/70
Inventor 杨勇沈坤龙孙芳芳
Owner HANGZHOU DIANZI UNIV