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Application of mesenchymal stem cells combined with PRP (platelet-rich plasma) in preparation of medicine for treating knee joint cartilage injury and osteoarthritis

A technology for stem cells and osteoarthritis, applied in the field of stem cells, can solve the problems of limited maintenance time, high cost, poor effect, etc., and achieve the effects of favorable recovery, significant therapeutic effect, and good preventive effect.

Pending Publication Date: 2021-10-22
吴志新 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High cost, poor effect, limited maintenance time

Method used

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  • Application of mesenchymal stem cells combined with PRP (platelet-rich plasma) in preparation of medicine for treating knee joint cartilage injury and osteoarthritis
  • Application of mesenchymal stem cells combined with PRP (platelet-rich plasma) in preparation of medicine for treating knee joint cartilage injury and osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: The application of mesenchymal stem cells combined with PRP in the preparation of medicines for the treatment of knee cartilage damage and osteoarthritis,

[0021] In this example, 210 patients with knee cartilage injury diagnosed by MR images and clinicians from August 2021 to December 2022 were selected.

[0022] Exclusion criteria for selected objects: ① patients with a history of hyaluronic acid injection within half a year; ② patients with a recent history of viral infection and heavy smoking and drinking.

[0023] S1: Mesenchymal Stem Cell Preparation

[0024] The fresh infant umbilical cord after birth was obtained with the consent of the parents. After removing the umbilical artery and vein, the residual tissue was cut into pieces of 0.5-1.5 mm. Type II collagenase (2 mg / ml) was added and placed in a 37°C constant temperature shaking incubator to shake and digest for 3- 4h, filter with 70μm filter. The cell suspension was washed by centrifugation at...

Embodiment 2

[0031] Example 2: Patient 1, male, 63 years old. Chief Complaint: Pain in both knees with difficulty in walking for 5 years, aggravated with swelling of knee joints for 3 years. After retirement, the patient likes mountain climbing, climbing once a week for about 4 hours. 5 years ago, bilateral knee swelling, accompanied by difficulty walking. Oral Fenbid, 1 tablet / day, can relieve. I still insist on climbing. Three years ago, my knees were swollen and painful when I woke up in the morning. The effect of oral administration of Fenbid is not good. I walked for less than 5 minutes and walked slowly. In the orthopaedic clinic of our hospital, MR examination of the knee joint was performed. CONCLUSION: Both knees have osteoarthritis with severe articular cartilage damage. Intravenous injection of hyaluronic acid is given to the knee joint, which can be relieved after braking and rest. After 3 months, the swelling of the knee joint occurred again, and the effect of intra-artic...

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PUM

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Abstract

The invention discloses application of a mesenchymal stem cell and PRP (platelet-rich plasma) combined in preparation of a medicine for treating knee joint cartilage injury and osteoarthritis, the mesenchymal stem cell and the platelet-rich plasma are combined for treating the knee joint cartilage injury and the osteoarthritis, and the platelet-rich plasma can relieve the knee joint injury symptom and also can be used for treating the knee joint cartilage injury and the osteoarthritis. The cartilage differentiation of the mesenchymal stem cells in the knee joint cavity can be promoted, so that the cell repair and regeneration of the knee joint cartilage injury can be realized, the symptom of a patient can be greatly reduced, and the patient can recover more easily.

Description

technical field [0001] The invention relates to the technical field of stem cells, in particular to the application of mesenchymal stem cells combined with PRP in the preparation of medicines for treating knee cartilage injury and osteoarthritis. Background technique [0002] Knee articular cartilage belongs to hyaline cartilage. Due to the lack of blood supply in the cartilage tissue, the repair ability is extremely poor. There is little possibility of self-repair after cartilage damage. At present, in the clinical treatment of knee pain and dysfunction caused by cartilage damage, artificial joint replacement, drilling microfracture, autologous or allogeneic cartilage transplantation or palliative treatment (intravenous injection of hyaluronic acid) are often used. The cost is high, the effect is poor, and the maintenance time is limited. Knee injuries are more common in middle-aged and elderly people and athletes, and are caused by incorrect walking posture. [0003] Me...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K35/19A61K9/00A61P19/04A61P19/02
CPCA61K35/28A61K35/19A61K9/0019A61P19/04A61P19/02A61K2300/00
Inventor 吴志新李飚李沛沛樊小莉
Owner 吴志新
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