36 results about "Knee joint cavity" patented technology

The invention in some embodiments relates to a dynamic seal for a prosthetic knee. The dynamic seal in one embodiment is utilized to seal a magnetorheological fluid comprising a liquid and solid particles within a chamber of the knee. The dynamic seal embodiments are specially configured with a pre-loaded tensioned garter spring which has a coil spacing that is at least as large as the size of the particles or maximum size of the particles in the magnetorheological fluid. Desirably, this allows the magnetorheological fluid particles to flow in and out of the dynamic seal without clogging the seal and advantageously provides for a reliable dynamic seal.

The invention relates to a regenerative implant of a cruciate ligament and a preparation method and application thereof. A surgical suture-shaped structure made of a degradable high molecule polymerization material is used as an initial mechanical support structure; a membrane-shaped structure made of a composite electrostatic spinning timbering material is used as a core structure for tissue remodeling and regeneration to be tightly wrapped in a winding mode on the initial mechanical support structure so as to form ligament regeneration elements; the multiple ligament regeneration elements form a ligament regeneration element set which is the regenerative implant of the ligament. The results of a goat animal experiment confirms that the implant is completely degraded within 52 weeks after being implanted to an organism, is induced to form an autogenous ligament tissue in the cavity of a knee joint, and induces the bone tunnel interface of a tibia and a femur to form tendon-bone healing; the maximum pulling force of the regenerated ligament is 20-60% that of a normal ligament tissue within 12 months after the implant is implanted to the organism.

The invention relates to a knee joint anterior and posterior cruciate ligament femoral tunnel positioner. The positioner comprises a hook body, wherein the hook head of the hook body extends in the knee joint cavity and points to the anterior and posterior cruciate ligament femoral insertion; the long stem of the hook head is upward and above the front of the femur of knee joint and is connected with an arc chute which is arranged laterally; a curved lever which can slide relatively to the arc chute is embedded in the arc chute; and the movable end of the curved lever is provided with a drillstem guide sleeve which directly points to the tip of the ligament hook head. By adopting the positioner of the invention, the problem that the previous arthroscope can perform observation only through the lateral approach and the visual blind area is caused, can be solved; and the reconstruction of femoral tunnel can be better performed from the physical point of the ligament, thus the reconstruction of femoral tunnel in clinic has higher repeatability and operability, the accuracy degree of operations is greatly increased, the operating time is reduced, and the positioner has great use value and wide market space.

The invention discloses an endoprosthesis for reestablishment of knee joint cruciate ligaments under a full arthroscope. The endoprosthesis comprises a first bolt prosthesis and a second bolt prosthesis which are connected to a thighbone and a shinbone respectively, wherein an artificial tendon prosthesis is connected between the first bolt prosthesis and the second bolt prosthesis; each of the first bolt prosthesis and the second bolt prosthesis comprises a bolt prosthesis front section and a bolt prosthesis back section, and the bolt prosthesis front section and the bolt prosthesis back section are in detachable connection with each other; the bolt prosthesis front section is provided with a self-tapping external thread capable of tapping into the thighbone and the shinbone; the outer surface of the bolt prosthesis back section is provided with an external thread continuously butted with the self-tapping external thread of the bolt prosthesis front section, and adopts a material capable of growing together with bones; and muscle tendon fixation forcing screws are arranged between the first bolt prosthesis and the artificial tendon prosthesis and between the second bolt prosthesis and the artificial tendon prosthesis. Physical fixation and biological fixation are combined to realize the reestablishment of the knee joint cruciate ligaments without establishing a bone channel penetrating through the thighbone, a knee joint cavity and the shinbone, so that operation difficulty is obviously reduced, various complications are avoided, the tensile force of the reestablished artificial ligaments can be adjusted, the operation accuracy is improved and the operation curative effect is promoted.

Provided is a simplified combined device used for knee joint cavity lavage. The invention relates to the field of medical instruments. The structure comprises a puncture needle, a guide wire, two irrigation catheters, two transfusion devices, and two drainage devices. Using the above structure, the two irrigation catheters are respectively put in a join cavity through two sides of a knee joint, and the irrigation catheters are respectively connected with the transfusion devices and the drainage devices. Firstly, a flow velocity regulator of the transfusion device on a side is switched on, and the flow velocity regulator of the drainage device on the same side is switched off, the flow velocity regulator of the transfusion device on the opposite side is switched off, and the flow velocity regulator of the drainage device on the opposite side is switched on, and thus, the joint cavity is lavaged. Then, the open flow velocity regulator of the transfusion device on one side is switched off, and the flow velocity regulator of the drainage device on the same side is switched off, and the flow velocity regulator of the transfusion device on opposite side is switched on, and the flow velocity regulator of the drainage device on the opposite side is switched off, and the joint cavity is lavaged in a crossed manner. The simplified combined device used for knee joint puncture lavage is simple in structure, and can effectively lavage joint cavities, and is economical and practical.

The invention provides a preparation method of a targeting chondrocyte exosome. The preparation method comprises the following steps of preparing an exosome carrier, preparing a targeting cartilage exosome, and preparing miRNA-140 wrapped by the targeting cartilage exosome. The preparation method has the beneficial effects that the miRNA medicine is delivered with treatment potential, high efficiency and tissue specificity for treating osteoarthritis, the application of the miRNA-140 wrapped by the targeting exosome in the medicine for treating osteoarthritis is mainly utilized, in an osteoarthritis animal model of a rat, the expression of MMP-13 can be inhibited by injecting the miRNA-140 into a knee joint cavity, the damage of cartilage matrix can be obviously improved, the cartilage damage process of an osteoarthritis animal model is delayed, and the cartilage protection effect is achieved, and therefore, the exosome is used for transporting miRNA-140 in a targeted manner, degradation of cartilage tissues can be slowed down, and the effect of inhibiting catabolism of cartilage matrix is achieved, so that the damage of articular cartilage is controlled, and cartilage repair is promoted.

The invention discloses a sterile bag for puncture lavage of the knee joint cavity. The sterile bag for puncture lavage of the knee joint cavity comprises a sterile bag body, a sterile box and an isolation mechanism. The sterile box is wrapped in the sterile bag body, the isolation mechanism is positioned in the sterile box, and the box body is of a hollow structure; an upper cover is hinged to the box body and rotates along the edge of the side, close to an opening, of the box body, and a middle laminated board is connected with the box body slidably and positioned on the side, close to the opening, of the box body; a plurality of partition boards are fixedly connected with the box body and the middle laminated board separately and transversely and longitudinally staggered, and the box body and the middle laminated board are divided into a plurality of placing cavities; shaping sponges are fixedly connected with the box body and positioned on the side, close to the inner wall, of thebox body, a placing column is fixedly connected with the box body and positioned in the box body, and a disinfection sponge is fixedly connected with the placing column and positioned at the bottom ofthe placing column. Cotton swabs are placed in the placing column and used for separating, isolating and classifying medical instruments, correspondingly medical personnel can conveniently find and take the medical instruments, unnecessary waste of treatment time is reduced, and treatment pain of patients is reduced.

The invention discloses a stem cell preparation for treating canine arthritis and a preparation method thereof. The stem cell preparation comprises canine mesenchymal stem cells, canine serum albumin, hyaluronic acid and pharmaceutical salts. Injections of the mesenchymal stem cells are skillfully used, a knee joint cavity is positioned through B-mode ultrasound, the cells are injected into the knee joint cavity of an affected limb more accurately, and a traditional treatment method for the canine arthritis is broken. The stem cell preparation is high in stability, good in therapeutic effect, safe in using, suitable for being preserved and transported for a long time and free of toxic and side effects, and lays the foundation for being used clinically on a large scale.

The invention relates to a knee joint anterior and posterior cruciate ligament femoral tunnel positioner. The positioner comprises a hook body, wherein the hook head of the hook body extends in the knee joint cavity and points to the anterior and posterior cruciate ligament femoral insertion; the long stem of the hook head is upward and above the front of the femur of knee joint and is connected with an arc chute which is arranged laterally; a curved lever which can slide relatively to the arc chute is embedded in the arc chute; and the movable end of the curved lever is provided with a drillstem guide sleeve which directly points to the tip of the ligament hook head. By adopting the positioner of the invention, the problem that the previous arthroscope can perform observation only through the lateral approach and the visual blind area is caused, can be solved; and the reconstruction of femoral tunnel can be better performed from the physical point of the ligament, thus the reconstruction of femoral tunnel in clinic has higher repeatability and operability, the accuracy degree of operations is greatly increased, the operating time is reduced, and the positioner has great use value and wide market space.

The invention discloses a fixing suspension device for a posterior cruciate ligament avulsion fracture reduction surgery and an operation method. a) Knee joint cavity posterior mediastinal tissues and avulsion bone block surrounding fascia tissues need to be cleaned in the surgery to facilitate fracture exposure and reduction in the surgery; b) after avulsion bone block reduction, an ACL reconstruction dead point positioner needs to be used for holding, a 4.5 mm positioning rod needs to drill out from the middle part of a bone block, a PDS wire is introduced along the inside of the positioning rod, and the additional use of a wire feeding device is not needed; and c) during fixation, a wire ring is forcibly tensioned at a knee bending position of about 90 degrees and is extruded and fixed, so that the posterior cruciate ligament is in the most relaxed state, a fracture block and a bone bed can keep tight fit to maintain stable reduction of the bone block. The operation steps are few, the operation is simple and easy to implement, fracture reduction and fixation are firm and reliable, when the joint moves, the fracture end can slightly move, the BO principle of fracture healing is met, and fracture healing is facilitated, rehabilitation exercises can be performed as soon as possible to recover the joint function.

A Chinese medicine in the form of polylactic acid microballs for treating osteoarthritis features that its active components are contained in each microball for slow releasing and selective absorption.

The invention discloses a drill bit guider for high tibial osteotomy. The drill bit guider comprises positioning rods, a positioning block, sliding rods, sliding rod locking bolts, a drill module anda universal adjustment mechanism, the quantity of the positioning rods is two, the front ends of the positioning rods are inserted into the knee joint cavity of a patient, and the middle portions or the rear ends of the positioning rods are fixedly connected with the positioning block; the sliding rods are inserted into through holes at the positioning block, and the sliding rod locking bolts arescrewed into threaded holes at the positioning block, and prop against the sliding rods; and the drill module is close to a position, needing spacer implantation, of the proximal tibia of the patient,and is connected with the sliding rods through the universal adjustment mechanism, and the drill module is provided with a row of drill bit guiding holes corresponding to the tibia of patient. The position and the angle of tibia drilling are adjusted by the sidling rods and the universal adjustment mechanism by using a tibial platform as a positioning reference, so the drilling difficulty is greatly reduced, thereby the drilling accuracy in high tibial osteotomy is ensured, the smooth implantation of the spacer is guaranteed, the operation efficiency is effectively improved.

The invention discloses application of a mesenchymal stem cell and PRP (platelet-rich plasma) combined in preparation of a medicine for treating knee joint cartilage injury and osteoarthritis, the mesenchymal stem cell and the platelet-rich plasma are combined for treating the knee joint cartilage injury and the osteoarthritis, and the platelet-rich plasma can relieve the knee joint injury symptom and also can be used for treating the knee joint cartilage injury and the osteoarthritis. The cartilage differentiation of the mesenchymal stem cells in the knee joint cavity can be promoted, so that the cell repair and regeneration of the knee joint cartilage injury can be realized, the symptom of a patient can be greatly reduced, and the patient can recover more easily.

The invention discloses a simplified combined device for lavage of the knee joint cavity, which is composed of a drainage tube, a rubber membrane, a miniature nut, a lavage tube, a breathable membrane, a three-way tube and a liquid delivery component. The rubber membrane Sleeved on the front end of the drainage tube, and the miniature nut is fixed, first turn the liquid delivery assembly to the front end, and then drive the irrigation tube to resist the rubber membrane, start the liquid delivery assembly, and discharge A small amount of cleaning liquid discharges the air in the lavage tube from the air-permeable membrane at the vent hole into the drainage tube, and then continues to rotate the liquid delivery assembly to drive the lavage tube to puncture the rubber membrane Lavage can prevent the patient's joint cavity from being impacted by the airflow and improve the patient's comfort.

The invention relates to the field of medical apparatuses and instruments, in particular to a posterior cruciate ligament tibia positioner. The posterior cruciate ligament tibia positioner comprises aguiding handle, a positioning hook, a locking wheel, a sleeve and a locking mechanism; a sliding groove is formed in the guiding handle, the positioning hook is in sliding connection with the interior of the sliding groove, a threaded hole is formed in the sliding groove, a locking wheel is in threaded connection with the threaded hole, a through hole is formed in the guiding handle, a sleeve isin sliding connection with the through hole, and the sleeve and the guiding handle are fixed through the locking mechanism. The posterior cruciate ligament tibia positioner is easy and convenient to operate, by adopting the posterior medial approach placement mode, positioning and repairing operation are performed, soft tissue obstruction inside a knee joint cavity, sight blur and other problems and blood supply damage risk in the operation process are reduced, the ligament residual end does not need to be cut off, ligament healing and blood vessel neuralization are facilitated, and the operation success probability is increased.

The utility model provides a bidirectional knee joint cavity injection stool which comprises a bottom plate, supporting legs are installed at the bottom end of the bottom plate, four supporting columns are installed at the top end of the bottom plate, installation cavities extending inwards are formed in the tops of the supporting columns, an electric servo push rod is installed at the position, between two baffles, of the top end of the bottom plate, and a seat cushion is installed at the top end of the electric servo push rod. Guide assemblies are mounted in the two mounting cavities located on the same side, and the use height of the seat can be adjusted through an arranged electric servo push rod, so that a tall medical worker does not need to excessively stoop to cause waist ache during injection; by arranging a pedal, the feet of the patient can be supported through the pedal when the feet cannot make contact with the surface of the bottom plate, and the patient can sit on the seat cushion from the left side of the bottom plate or the right side of the bottom plate according to the injection side of the affected limb; and therefore, medical staff can perform knee joint intracavity injection on a patient without adjusting the position of the medical staff, and the injection efficiency is effectively improved.

The utility model relates to a hip and knee joint cavity perfusion drainage device. The device comprises a drug delivery mechanism and a suction mechanism which are arranged in vitro; the drug feeding mechanism is connected with a drug injection header pipe, the suction mechanism is connected with a drainage header pipe, and the drug injection header pipe and the drainage header pipe enter a human body through a skin incision; the medicine injection header pipe is arranged in a forked mode after entering a human body to form medicine injection branch pipes used for being placed in a hip joint cavity or a knee joint cavity, and medicine injection holes are evenly distributed in the medicine injection branch pipes. The main drainage pipe is arranged in a forked mode after entering the body, and a suction branch pipe used for being placed in a hip joint cavity or a knee joint cavity is formed. According to the utility model, a self-made simple medicine injection drainage tube commonly used in clinic at present can be replaced, so that the local part of an articular cavity is continuously, stably and uniformly dosed, the optimal effect of locally applying antibiotics is achieved, and the stable high-concentration state of the antibiotics is maintained. Meanwhile, skin incisions can be reduced, and the risks of incision infection and reverse infection are avoided.

The invention discloses a knee-joint cavity implant for treating popliteal cyst. The knee-joint cavity implant comprises a knee-joint cavity sealing sheet (12) and a stop sheet (16), wherein a through hole (14) is opened in the knee-joint cavity sealing sheet (12); the peripheral area of the stop sheet (16) is fixed on the knee-joint cavity sealing sheet (12), thus the stop sheet (16) is capable of shielding the through hole (14); moreover, a flow through hole (162) is opened in the junction of the peripheral area of the stop sheet (16) and the knee-joint cavity sealing sheet (12), thus the stop sheet (16) and the knee-joint cavity sealing sheet (12) are capable of forming a flow cavity (20). The knee-joint cavity implant above is capable of effectively improving the treatment effect on popliteal cyst.

The invention discloses application of resveratrol-polylactic acid long-acting nano-microspheres in preparation of an anti-osteoarthritis drug, and belongs to the field of osteoarthritis treatment. The preparation method of the nano-microspheres comprises the following steps of: jointly dissolving resveratrol and polylactic acid in dichloromethane to form an organic phase; mixing the organic phase with a PVA solution I, performing high-speed shearing under an ice bath condition to form an emulsion, then slowly dripping the emulsion into a PVA solution II, performing stirring at a low speed to volatilize an organic solvent, and collecting microspheres; and centrifuging the collected microspheres, discarding the supernate, cleaning the nano-microspheres, and performing freeze-drying to obtain the resveratrol-polylactic acid long-acting nano-microspheres. The preparation method is simple and easy to operate; the stability of the resveratrol-polylactic acid nano-microspheres is improved by optimizing preparation conditions; the resveratrol-polylactic acid nano-microspheres are suitable for industrial popularization and application; and the nano-microspheres can remarkably relieve cartilage injury, synovitis and other symptoms after knee joint cavity injection and can be used for development of drugs for treating knee osteoarthritis.

The invention discloses a knee-joint cavity implant for treating popliteal cyst. The knee-joint cavity implant comprises a knee-joint cavity sealing sheet (12) and a stop sheet (16), wherein a through hole (14) is opened in the knee-joint cavity sealing sheet (12); the peripheral area of the stop sheet (16) is fixed on the knee-joint cavity sealing sheet (12), thus the stop sheet (16) is capable of shielding the through hole (14); moreover, a flow through hole (162) is opened in the junction of the peripheral area of the stop sheet (16) and the knee-joint cavity sealing sheet (12), thus the stop sheet (16) and the knee-joint cavity sealing sheet (12) are capable of forming a flow cavity (20). The knee-joint cavity implant above is capable of effectively improving the treatment effect on popliteal cyst.

The invention discloses a preparation method of a novel rat osteoarthritis model. The preparation method comprises the following steps of (1), preparing a photothermal nano material Cu9S5@SiO2; (2), conducting intraperitoneal anesthesia on abdominal cavities of SD male rats at the age of 6-8 weeks and with the weight of 180-240 g by using 1% pentobarbital at a dose of 40 mg / Kg, injecting 100 microliters of 100 Mug / ml evenly mixed Cu9S5@SiO2 solution into articular cavities, and injecting into knee joint cavities of the rats through infrapatellar ligaments of the rats; (3), using a 980 nm, 0.72W / cm<2> near-infrared laser for irradiation of rat knee joints, wherein the irradiation continues to be conducted for 10 min after the maximum temperature of the rat knee joints exceeds 50 DEG C; (4), after 4 weeks, taking right knee joints of the SD rats to evaluate the damage situation through knee joint cartilage HE staining. The method is simple to operate, quantification and precise controlof energy damage can be achieved, and the temperature rise condition can be monitored under a thermal imager to achieve the visualization of the damage process.

The invention discloses a knee-joint endoscope. The knee-joint endoscope is used for the internal part of a knee-joint cavity. A housing shape of the knee-joint endoscope is spherical. A housing comprises a shell and a transparent front cover. A reinforcing component is arranged between a first connecting portion of the shell and a second connecting portion of the transparent front cover. The internal part of the knee-joint endoscope is provided with an endoscope main body, a data line, and a micro digital video. The micro digital video is connected with the endoscope main body through the data line. In the knee-joint endoscope, the housing shape of the knee-joint endoscope is spherical, and the knee-joint endoscope ensures that other tissues in the knee-joint cavity would not be damaged when the knee-joint endoscope enters the knee-joint cavity of a patient and is used, and soft tissues in the knee-joint cavity block and clamp motions of the knee-joint endoscope is prevented, and secondary damage on the patient is prevented. Using the knee-joint endoscope can reduce the number of punching on skin of the patient when doctors performs a knee-joint cavity operation.

The invention discloses a knee joint cavity puncturing and flushing device, and relates to the technical field of knee joint cavity puncturing. The device comprises a supporting block, the top of the supporting block is bent, the top of the supporting block is attached to a knee bend, a fixing mechanism is fixedly connected with the surface of the supporting block, the output end of a driving mechanism is fixedly connected with the surface of a puncture mechanism, the outer side face of a flushing assembly is slidably connected with a mounting plate, and the mounting plate is fixedly connected with the output end of the driving mechanism. The outer puncture needle is fixedly connected to one end of the flushing assembly, the inner puncture needle is arranged inside the outer puncture needle, the inner puncture needle is fixedly connected with the end, close to the outer puncture needle, of the flushing assembly, the top of the supporting block attached to the knee bend can support popliteal fossa, the joint is in a relaxed state, the puncture needle is easy to penetrate, and the intra-articular structure is not prone to being damaged. The inner puncture needle and the outer puncture needle can achieve the dual effects of extracting and flushing joint fluid through one-time puncture, and the environment in a knee joint cavity is improved to the maximum extent.

Systems and techniques can be provided to generate sensorized insights into the characteristics of a knee joint space during a knee replacement procedure. In some implementations, a sensor support body carrying one or more sensors can be used to measure and inform the clinician of the varus / valgus angles of the tibia and femur, allowing the clinician to adjust the surgical procedure to accommodate the measured angles. The clinician may simulate changes to the load balance across the knee joint in response to potential dimensional changes to the knee joint prior to actually surgically implementing the changes.

The invention relates to a preparation method of simvastatin-carrying ultrasonic targeting microbubbles. The preparation method comprises the following steps of dissolving simvastatin in tetrahydrofuran, and diluting with normal saline until the concentration is 0.01-0.1 mg / mL; adding trimethyl chitosan and sodium tripolyphosphate, compounding to form a stable spatial network result, obtaining a suspension, freeze-drying and re-dissolving the suspension, transferring the obtained liquid into a small bottle filled with C3F8 gas, oscillating the small bottle by using a mechanical oscillator to form 0.05 mg / mL simvastatin microbubbles, filling high-pressure C3F8 gas into the remaining space of the small bottle, sealing and storing, and refrigerating for later use; and feeding simvastatin microbubbles into a knee joint cavity, applying ultrasonic waves at the same time, controlling the ultrasonic intensity and time, wherein targeted induction microbubble rupture reaches the maximum proportion. The administration targeting property is strong, the administration period is shortened, the side effect of long-term administration is reduced, and the administration dosage is reduced.

The invention discloses an endoprosthesis for reestablishment of knee joint cruciate ligaments under a full arthroscope. The endoprosthesis comprises a first bolt prosthesis and a second bolt prosthesis which are connected to a thighbone and a shinbone respectively, wherein an artificial tendon prosthesis is connected between the first bolt prosthesis and the second bolt prosthesis; each of the first bolt prosthesis and the second bolt prosthesis comprises a bolt prosthesis front section and a bolt prosthesis back section, and the bolt prosthesis front section and the bolt prosthesis back section are in detachable connection with each other; the bolt prosthesis front section is provided with a self-tapping external thread capable of tapping into the thighbone and the shinbone; the outer surface of the bolt prosthesis back section is provided with an external thread continuously butted with the self-tapping external thread of the bolt prosthesis front section, and adopts a material capable of growing together with bones; and muscle tendon fixation forcing screws are arranged between the first bolt prosthesis and the artificial tendon prosthesis and between the second bolt prosthesis and the artificial tendon prosthesis. Physical fixation and biological fixation are combined to realize the reestablishment of the knee joint cruciate ligaments without establishing a bone channel penetrating through the thighbone, a knee joint cavity and the shinbone, so that operation difficulty is obviously reduced, various complications are avoided, the tensile force of the reestablished artificial ligaments can be adjusted, the operation accuracy is improved and the operation curative effect is promoted.

The invention discloses a knee joint model capable of demonstrating pressure change in a knee joint cavity in KOAPT movement. The model comprises a thighbone structure and a tibia structure, the thighbone structure comprises an upper thighbone structure and a lower thighbone structure which are vertically and hermetically connected, and a communicating pipe is embedded in the thighbone structure; the tibia structure comprises an upper tibia structure and a lower tibia structure which are hermetically connected up and down; a cylindrical elastic film which is used for simulating a knee joint synovial membrane and is provided with openings at two ends is sleeved between the lower thighbone structure and the upper tibia structure in a sealing manner, so that a completely sealed knee joint cavity is formed in the elastic film; artificial synovial fluid is injected into the communicating pipe into the knee joint cavity, the thighbone structure is swung, knee pain inducing movement is demonstrated, and the pressure change in the knee joint cavity is detected through the pressure meter connected with the top end of the communicating pipe. According to the invention, the blank that various knee joint models do not simulate the knee joint cavity and synovial fluid is filled up, and the pressure change in the joint cavity during knee pain inducing movement is clearly and intuitively demonstrated.

The invention relates to a preparation method of ultrasound-targeted microbubbles carrying simvastatin, which comprises dissolving simvastatin in tetrahydrofuran and diluting physiological saline to a concentration of 0.01-0.1 mg / mL; adding trimethyl chitosan, Sodium tripolyphosphate, then, compounded into a stable space network, obtained a suspension, freeze-dried and redissolved, transferred the obtained liquid to a vial filled with C3F8 gas, and vibrated the vial with a mechanical oscillator to form a 0.05 mg / mL simvastatin microbubbles, fill the remaining space of the vial with high-pressure C3F8 gas and seal it up, and refrigerate it for later use; inject simvastatin microbubbles into the knee joint cavity and apply ultrasound at the same time, control the ultrasound intensity and time, and target to induce microbubble rupture to reach the maximum ratio. The administration is highly targeted, the medication cycle is shortened, the side effects of long-term medication are reduced, and the dosage of the medication is reduced.