Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polylactic acid microglobule Chinese medicine compound for mula used for treating bone arthritis and its preparation method

A technology of polylactic acid microspheres and polylactic acid is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The effect of improving the therapeutic effect

Inactive Publication Date: 2005-01-05
GUANGDONG PHARMA UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when Western medicine treats osteoarthritis, although the curative effect is obvious, the side effects are relatively large. In the long-term and large amount of clinical practice, traditional Chinese medicine has accumulated rich experience in the treatment of osteoarthritis and achieved satisfactory curative effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polylactic acid microglobule Chinese medicine compound for mula used for treating bone arthritis and its preparation method
  • Polylactic acid microglobule Chinese medicine compound for mula used for treating bone arthritis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of "Guyan No. 1" polylactic acid microspheres

[0013] The invention adopts double emulsion-solvent volatilization method to prepare "Guyan No. 1" polylactic acid microspheres, that is, polylactic acid is dissolved in methylene chloride to form an organic phase, and an appropriate amount of gelatin is dissolved in the concentrated extract of "Guyan No. 1" to form Water phase, add the water phase to the organic phase, stir and homogenize to form colostrum (W / O), then transfer the colostrum into the aqueous solution containing PVA, stir to form double emulsion (W / O / W), remove the organic solvent, centrifuge The microspheres were separated by filtration and dried under reduced pressure to obtain the "Guyan No. 1" polylactic acid microspheres. Wherein the gelatin concentration is 8%, the volume ratio of the inner water phase and the oil phase is 2:5, the stirring speed during dispersion is 1200r / min, and the polylactic acid concentration is 20%.

Embodiment 2

[0014] Example 2 Determination of Drug Loading Capacity and Encapsulation Efficiency of "Guyan No. 1" Polylactic Acid Microspheres

[0015] The contents of psoralen and isopsoralen were determined by high performance liquid chromatography. The chromatographic condition is that the chromatographic column is Dramonsid TM -C 18 Column (250mm×4.6mm, 5μm, Dima Company), mobile phase is methanol-1% acetic acid (60:40), flow rate: 0.8ml min -1 ; Detection wavelength: 245nm; Column temperature: room temperature. The test solution is to accurately weigh about 0.1g of the polylactic acid microsphere sample of Bone Yan No. 1, put it in a stoppered Erlenmeyer flask, add 10ml of methanol, seal it tightly, weigh it, soak it overnight, extract it by ultrasonic for 30min, let it cool, add Make up the lost weight with methanol, filter, discard the initial filtrate, and continue to filter the filtrate through a 0.45 μm membrane filter. Get the test solution 10μl into the chromatograph, calc...

Embodiment 3

[0019] Example 3 Observation on the Morphology, Particle Size and Distribution of Polylactic Acid Microspheres "Guyan No. 1"

[0020] The appearance of the microspheres was observed with an optical microscope and an electron scanning microscope, and the particle size and particle size distribution of the microspheres were investigated with a microscopic counting method, and each count was not less than 500 particles.

[0021] Observed under optical microscope and scanning electron microscope ( figure 1 ), the shape of "Guyan No. 1" microspheres is round, the surface is smooth, and the distribution is even.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
glass transition temperatureaaaaaaaaaa
Login to View More

Abstract

A Chinese medicine in the form of polylactic acid microballs for treating osteoarthritis features that its active components are contained in each microball for slow releasing and selective absorption.

Description

technical field [0001] The invention relates to a polylactic acid microsphere of a traditional Chinese medicine compound. The invention also relates to a preparation method of the polylactic acid microspheres of the above-mentioned traditional Chinese medicine compound. Background technique [0002] Osteoarthritis (osteoarthritis) is the most common joint disease in the world, according to statistics, 80% of people over 60 years old are affected by it. With the aging of the population, the incidence of osteoarthritis is increasing, which seriously affects the social labor force and the quality of life of patients. At present, Western medicine has obvious curative effect in the treatment of osteoarthritis, but it has relatively large side effects. In the long-term and large amount of clinical practice, traditional Chinese medicine has accumulated rich experience in the treatment of osteoarthritis and achieved satisfactory curative effect. The traditional Chinese medicine tr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/34A61P19/02
Inventor 杨帆李明亚金描真
Owner GUANGDONG PHARMA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com