Application of ethanol extract from fruiting bodies of Cordyceps guangdong in the preparation of drugs for preventing obesity and hyperlipidemia

A technology of ethanol extraction and Cordyceps guangdong, which is applied in application, drug combination, and pharmaceutical formula, can solve the problems of weight gain in obese mice

Active Publication Date: 2022-07-01
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that Cordyceps sinensis, Cordyceps militaris and cicadae can reduce the weight of obese mice, but the research on the fruiting bodies of Cordyceps guangdong to alleviate the weight gain and blood lipid reduction of obese mice and the development of related products have not been reported

Method used

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  • Application of ethanol extract from fruiting bodies of Cordyceps guangdong in the preparation of drugs for preventing obesity and hyperlipidemia
  • Application of ethanol extract from fruiting bodies of Cordyceps guangdong in the preparation of drugs for preventing obesity and hyperlipidemia
  • Application of ethanol extract from fruiting bodies of Cordyceps guangdong in the preparation of drugs for preventing obesity and hyperlipidemia

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Preparation of Cordyceps guangdong ethanol extract.

[0027] Weigh 600 g of the fruiting body of Cordyceps guangdong, dry it in an oven at 50-60 °C for 3-4 hours, and use an ultra-low temperature pulverizer to prepare the fruiting body powder of Cordyceps guangdong. Add 4L of 55% edible alcohol by volume, soak for 24h, collect the filtrate, repeat once. The extracts were combined, concentrated and dried under reduced pressure using a rotary evaporator at 55° C. and 60 rpm to obtain 45.69 g of solid primary extract. 1.35 L of physiological saline was added, and the solution was fully mixed to obtain an ethanolic extract solution of Cordyceps guangdong fruiting bodies, which was stored at -80°C for later use.

Embodiment 2

[0029] The ethanol extract of Cordyceps guangdong was used to intervene high-fat-induced C57BL / 6J obese mice. The specific steps are as follows:

[0030] 1. Grouping of mice: 90 male C57BL / 6J mice were raised in the Experimental Animal Center of the Institute of Microbiology, Guangdong Academy of Sciences at a temperature of 23±1°C, a humidity of 55±10%, and alternating light and dark for 12 hours. After one week of adaptive culture, the mice were randomly divided into 9 groups with 10 mice in each group.

[0031] 2. Treatment: 3 groups of mice were fed with conventional feed, and 6 groups of mice were fed with high-fat feed containing 60% fat. Raised for 13 to 14 weeks, each mouse in the 3 groups of conventional feed and 3 of the high-fat feed groups was given 100 μL of 0.8% normal saline daily, and the 3 groups of high-fat feed groups were given 100 mg / kg / d of Cordyceps guangdong. Solid ethanol extract solution, and the body weight of mice was recorded weekly. Gavage for 2...

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Abstract

The invention discloses the application of the fruiting body ethanol extract of Cordyceps guangdong in the preparation of medicines for preventing obesity and hyperlipidemia. The present invention finds for the first time that the ethanol extract of Cordyceps guangdong can alleviate the weight gain by reducing the fat content in the groin, epididymis and liver of obese mice with a high-fat diet; reduce serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Density lipoprotein cholesterol content, thereby relieving the symptoms of hyperlipidemia. The fruiting body of Cordyceps guangdong has played an active and effective role in relieving obesity and hypolipidemic symptoms, has a good application prospect, and greatly expands its application field.

Description

Technical field: [0001] The invention belongs to the field of food and health care products, and in particular relates to the application of ethanol extract from fruiting bodies of Cordyceps guangdong in the preparation of medicines for preventing obesity and hyperlipidemia. Background technique: [0002] Cordyceps guangdongensis (≡Tolypocladium guangdongense) is a new resource food unique to South China. It belongs to the family Ophiocordycipitaceae together with Ophiocordyceps sinensis. The fruiting body of Cordyceps guangdong is safe and non-toxic, and can be artificially cultivated on a large scale; it has significant effects in the treatment of adenine-induced chronic renal failure and chronic bronchitis, anti-virus, anti-fatigue, etc.; rich in crude protein, amino acids, trace amounts elements and vitamins. In addition, the fruiting bodies of Cordyceps guangdong contain active ingredients such as cordycepin, adenosine, flavonoids, saponins, and sterols, which have gre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/068A61P3/04A61P3/06A23L33/00A23L31/00
CPCA61K36/068A61P3/04A61P3/06A23L33/00A23L31/00A23V2002/00A61K2236/333A61K2236/51A23V2200/332A23V2200/3262A23V2250/208
Inventor 王刚正孙程远邓旺秋李泰辉李挺张成花黄浩
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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