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A degradable mesoporous silicon nano drug delivery system modified by peoz and polydopamine-gadolinium ion network and its preparation method

An ion network, polydopamine technology, applied in nano-drugs, nano-technology, pharmaceutical formulations, etc., can solve the problems of lack of existing space and transport pathways, hidden dangers of body damage, and the inability of treatment methods to fully meet the needs of precise tumor treatment. The effect of improving delivery efficiency and comprehensive therapeutic effect, good degradability in vivo, improving the ability of degradation and MRI imaging

Active Publication Date: 2022-04-08
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because there is a huge difference in properties between this kind of rigid nanoparticles and the chemical molecules that make up the life movement, when they accumulate in the human body, they often lack a reasonable space for existence and transport pathways, because they do not follow the absorption, distribution, and distribution of chemical molecules in the body. The rules of metabolism and excretion make it easy to interact with structures with similar volume or space complementarity in the body, such as embedding, embolism, adhesion and aggregation, which can easily cause potential damage to the body
[0005] With the in-depth research on composite nano-therapeutic platforms in the field of biomedicine, the research on treatment methods alone cannot fully meet the needs of precise tumor treatment.

Method used

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  • A degradable mesoporous silicon nano drug delivery system modified by peoz and polydopamine-gadolinium ion network and its preparation method
  • A degradable mesoporous silicon nano drug delivery system modified by peoz and polydopamine-gadolinium ion network and its preparation method
  • A degradable mesoporous silicon nano drug delivery system modified by peoz and polydopamine-gadolinium ion network and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of degradable mesoporous silicon nanoparticles (MSN-Man-DOX@PDA-Gd-PEOz, loaded with doxorubicin) modified by PEOz and polydopamine-gadolinium ion network

[0047] The preparation method comprises the following steps:

[0048] (1) Dissolve 0.9g of cetyltrimethylammonium bromide and 1.5g of ammonium fluoride in 250mL of ultrapure water, heat up to 80°C, add 4.5mL of tetraethyl orthosilicate and 1g of mannose, and continue Stir for 10 hours, centrifuge at 15,000 rpm for 20 minutes, wash the precipitate and redisperse it in 250 mL of ammonium nitrate ethanol solution with a concentration of 5.6 mg / mL, reflux at 80°C for 18 hours, centrifuge at 15,000 rpm for 20 minutes, wash and dry to obtain doped Mesoporous silica nanoparticles infused with mannose;

[0049] (2) Disperse 50 mg of the above-mentioned mesoporous silica nanoparticles in 100 mL of doxorubicin ethanol solution with a concentration of 1 mg / mL, continue stirring for 9 hours, centrifuge at...

Embodiment 2

[0054] Example 2 Preparation of degradable mesoporous silicon nanoparticles (MSN-Man-DOX@PDA-Gd-PEOz, loaded with doxorubicin) modified by PEOz and polydopamine-gadolinium ion network

[0055] The preparation method comprises the following steps:

[0056] (1) Dissolve 1.5g cetyltrimethylammonium bromide and 1.0g ammonium fluoride in 250mL ultrapure water, heat up to 80°C, add 4mL tetraethyl orthosilicate and 1g mannose, and keep stirring 6 hours, centrifuged at 10000rpm for 30 minutes, washed the precipitate and redispersed it in 250mL ammonium nitrate ethanol solution with a concentration of 5.6mg / mL, refluxed at 80°C for 24 hours, centrifuged at 10000rpm for 30 minutes, washed and dried to obtain the doped Mesoporous silica nanoparticles of mannose;

[0057] (2) Disperse 50 mg of the above-mentioned mesoporous silica nanoparticles in 100 mL of doxorubicin ethanol solution with a concentration of 1 mg / mL, continue stirring for 6 hours, centrifuge at 10000 rpm for 30 minutes,...

Embodiment 3

[0061] Example 3 Preparation of degradable mesoporous silicon nanoparticles (MSN-Man-DOX@PDA-Gd-PEOz, loaded with doxorubicin) modified by PEOz and polydopamine-gadolinium ion network

[0062] The preparation method comprises the following steps:

[0063] (1) Dissolve 1.1g of cetyltrimethylammonium bromide and 1.3g of ammonium fluoride in 250mL of ultrapure water. After heating up to 80°C, add 5mL of tetraethyl orthosilicate and 1g of mannose, and keep stirring After 12 hours, centrifuge at 20000rpm for 15 minutes, wash the precipitate and redisperse it in 250mL ammonium nitrate ethanol solution with a concentration of 5.6mg / mL, reflux at 90°C for 12 hours, centrifuge at 20000rpm for 15 minutes, wash and dry to obtain the doped Mesoporous silica nanoparticles of mannose;

[0064] (2) Disperse 50 mg of the above-mentioned mesoporous silica nanoparticles in 100 mL of doxorubicin ethanol solution with a concentration of 1 mg / mL, continue to stir for 12 hours, centrifuge at 20000...

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Abstract

The invention belongs to the technical field of drug delivery systems, in particular to a degradable mesoporous silicon nano drug delivery system modified by PEOz and polydopamine-gadolinium ion network and a preparation method. The present invention modifies the mesoporous silicon nano drug delivery system by combining mannose, polydopamine-gadolinium ions and PEOz; utilizes mannose with good biocompatibility to improve the in vivo degradability of the system; utilizes polydopamine-gadolinium Gadolinium ions promote drug release, improve the degradation of the system and the ability of nuclear magnetic resonance imaging; use PEOz to enable the system to penetrate deeply into the tumor for precise and efficient treatment, so that the prepared PEOz and polydopamine-gadolinium ion network modification can be degraded The mesoporous silicon nano drug delivery system has multiple functions such as good degradability in vivo, can be monitored by imaging, and can penetrate deeply into the tumor for precise and efficient treatment, which can greatly improve the delivery efficiency and comprehensive treatment effect.

Description

technical field [0001] The invention belongs to the technical field of drug delivery systems, and in particular relates to a degradable mesoporous silicon nano drug delivery system modified by PEOz and polydopamine-gadolinium ion network and a preparation method. Background technique [0002] Malignant tumors are one of the diseases that pose the most serious threat to human health. So far, although the medical technology for malignant tumors has been greatly developed, the traditional chemotherapy methods still cannot obtain good therapeutic effects in clinical practice. The reason is that the low selectivity of chemotherapeutic drugs for tumor cells makes the amount of them that can reach the tumor site very small, and it is easy to cause relatively large toxic and side effects on normal tissues. In view of the rapid development of nanoscience, establishing a therapeutic platform at the nanoscale has very obvious advantages, because by constructing a nano drug delivery sy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/704A61K9/51A61K47/34A61K47/26A61K47/04A61P35/00A61K49/12A61K49/08B82Y5/00B82Y40/00
CPCA61K41/0052A61K31/704A61K9/5146A61K9/5123A61K9/5115A61P35/00A61K49/12A61K49/085B82Y5/00B82Y40/00A61K2300/00
Inventor 曾小伟李子牧高楠莎梅林陈洪中刘赣
Owner SUN YAT SEN UNIV