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Microbial combined preparation compounded by postbiotics and bacteriophage as well as preparation method and application of microbial combined preparation

A bacteriophage and microorganism technology, applied in the field of microorganism application, can solve the problem of the microecological flora that cannot be quickly restored to the lesion, and achieve the effect of rapid colonization

Pending Publication Date: 2021-11-12
南京北极光生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the use of phage can play a good role in lysing harmful bacteria, it cannot quickly restore the balance of the microecological flora of the lesion

Method used

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  • Microbial combined preparation compounded by postbiotics and bacteriophage as well as preparation method and application of microbial combined preparation
  • Microbial combined preparation compounded by postbiotics and bacteriophage as well as preparation method and application of microbial combined preparation
  • Microbial combined preparation compounded by postbiotics and bacteriophage as well as preparation method and application of microbial combined preparation

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Experimental program
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Effect test

experiment example

[0060] 1. Experimental materials and experimental equipment

[0061] 1.1 Main reagents: LB medium, sterile water, broth medium, etc.

[0062] 1.2 Main equipment: electronic balance (Mettler-Toledo Instruments (Shanghai) Co., Ltd.), steam sterilizer (Shandong Boke Scientific Instrument Co., Ltd.), Mingmei microscope + computer (Guangzhou Mingmei Optoelectronics Technology Co., Ltd.), ultrasonic Cleaning instrument (Kunshan Ultrasonic Instrument Co., Ltd.), pH meter (Mettler-Toledo Instrument (Shanghai) Co., Ltd.), high-speed centrifuge (Shanghai Luxiangyi Centrifuge Instrument Co., Ltd.), constant temperature shaker (Shandong Boke Scientific Instrument Co., Ltd. Company), medical refrigerator freezer (Haier), heating magnetic stirrer (Shanghai Hengyi Scientific Instrument Co., Ltd.), electric thermostat incubator (Shanghai Hengyi Scientific Instrument Co., Ltd.), micro pipette (eppendorf and other experimental equipment).

[0063] 2. Experimental method:

[0064] In the follo...

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Abstract

The invention provides a microbial combined preparation compounded by a postbiotics and a bacteriophage. The microbial combined preparation comprises the postbiotics and the bacteriophage, the postbiotics can effectively inhibit the growth ability and activity of a harmful bacterium biological membrane, and the protection of the biological membrane on harmful bacteria is relieved, so that a rapid channel is opened for bacteriophage infection of the harmful bacteria. After the harmful bacteria are killed, the beneficial bacteria recover to occupy the epithelial cells of the focus, and rapid colonization and proliferation are realized under the action of the postbiotics, so that the balance of micro-ecological flora is achieved. In addition, according to the further research of the applicant, after the probiotics are compounded, the metabolite can further inhibit the formation of a biological membrane. Therefore, the speed of infecting harmful bacteria by the bacteriophage is higher, and the effect is better.

Description

technical field [0001] The invention provides a microbial combination preparation, a preparation method and an application thereof, and belongs to the technical field of microbial application. Background technique [0002] The surface skin of the human body and the oral cavity, upper respiratory tract, intestinal tract, genitourinary tract, and other mucous membranes and cavities that communicate with the outside world are inhabited by different types and quantities of microorganisms. Under normal circumstances, parasites live in peace with the host and adapt to each other. , and various microorganisms also restrict each other and maintain a state of mutual coexistence. Microecological flora exist in the human digestive tract, upper respiratory tract, skin, urethra, external genitalia, conjunctiva and external auditory canal. [0003] In recent years, more and more people have realized the importance of human flora. Taking the microecology of the intestinal flora as an exa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12N1/16C12N7/00A61K35/76A61K35/741A61K8/99A61P31/04A61Q19/00A23L33/135A23L33/10C12R1/225C12R1/245C12R1/25C12R1/01C12R1/46C12R1/44C12R1/07C12R1/125C12R1/645C12R1/24
CPCC12N1/20C12N1/16C12N7/00A61K35/76A61K35/741A61K8/99A61P31/04A61Q19/00A23L33/135A23L33/10C12N2795/00021C12N2795/00032A23V2002/00A23V2400/11A23V2400/231A23V2400/321A23V2400/413A23V2400/427A23V2400/517A23V2400/249A23V2400/519A23V2400/529A23V2400/531A23V2400/533A61K2300/00A23V2200/30Y02A50/30
Inventor 孙文李靖陆启东
Owner 南京北极光生物科技有限公司
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