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Lubricating fluid for orthokeratology lenses and orthokeratology lens product for preventing and treating myopia

A lubricant and atropine technology, applied in the field of eye health products, can solve problems such as limited vision improvement effect and corneal damage, and achieve the effects of increasing eye bioavailability, improving shaping effect, and making up for the lack of tear layer

Pending Publication Date: 2021-11-23
上海阿尔福斯医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The main purpose of the present invention is to provide a lubricating fluid for OK mirrors, OK mirror products for the prevention and treatment of myopia, to solve the problem that the OK mirrors in the prior art cause damage to the cornea and lead to limited vision improvement effects

Method used

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  • Lubricating fluid for orthokeratology lenses and orthokeratology lens product for preventing and treating myopia
  • Lubricating fluid for orthokeratology lenses and orthokeratology lens product for preventing and treating myopia
  • Lubricating fluid for orthokeratology lenses and orthokeratology lens product for preventing and treating myopia

Examples

Experimental program
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Effect test

preparation example Construction

[0040] The following preparation process is used to prepare the compound drug lubricant and the single drug lubricant to compare the differences in safety and curative effect, namely:

[0041] 1. Weigh sodium hyaluronate, add 80% of the prescribed amount of water for injection (temperature 70°C), stir and mix well, then adjust the volume to replenish water to 100%, and stir and mix evenly to prepare a sodium hyaluronate containing 0.8% (w / v) in aqueous solution;

[0042] 2. After cooling the feed liquid obtained in step 1 to room temperature, add atropine sulfate to form an aqueous solution with a concentration of 0.01% (w / v);

[0043] 3. In step 2 gained solution, add osmotic pressure buffer sodium chloride successively (osmotic pressure is adjusted to be 300mOsm / L), acid-base regulator phosphate buffered saline system (regulating pH is 6.0);

[0044] After mixing evenly, stir well, according to the relevant requirements of the "Chinese Pharmacopoeia 2020 Edition (4)" eye d...

Embodiment 1

[0068] Weigh sodium hyaluronate, add 60% of the prescribed amount of water for injection (temperature 60°C), stir well and mix evenly, then adjust the volume to 100%, and make an aqueous solution containing 0.5% (w / v) sodium hyaluronate, stir Mix evenly; After the feed liquid is cooled to room temperature, add atropine sulfate and be made into the aqueous solution that concentration is 0.001% (w / v); Add sodium chloride in solution, adjust osmotic pressure to be 260mOsm / L, add phosphate buffer system, And adjust the pH to 5.5, after mixing evenly, fully stir, according to the relevant requirements of "Chinese Pharmacopoeia 2020 Edition (Four Parts)", filter through a 0.22 μm microporous membrane, sterilize, single-dose aseptic subpackaging, and pass the light inspection. Promptly obtain lubricating liquid, this lubricating liquid viscosity is 7mps.

Embodiment 2

[0070] Weigh sodium hyaluronate, add 90% of the prescribed amount of water for injection (temperature 90°C), stir well and mix evenly, then adjust the volume to 100%, and make an aqueous solution containing 1.5% (w / v) of sodium hyaluronate, stir Mix evenly; After the feed liquid is cooled to room temperature, add atropine sulfate and be made into the aqueous solution that concentration is 0.02% (w / v); Add boric acid in solution, regulate osmotic pressure to be 320mOsm / L, add citrate buffer system, and Adjust the pH to 6.0, after mixing evenly, stir fully, according to the relevant requirements of "Chinese Pharmacopoeia 2020 Edition (Four Parts)", filter through a 0.22 μm microporous membrane, sterilize, single-dose aseptically dispensed, and pass the light inspection, that is, Obtain lubricating fluid, and this lubricating fluid viscosity is 28mps.

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Abstract

The invention provides a lubricating fluid for orthokeratology lenses and an orthokeratology lens product for preventing and treating myopia. The lubricating fluid for the orthokeratology lenses comprises 0.001%-0.05% (w / v) of atropine, 0.5%-1.5% (w / v) of sodium hyaluronate, an acid-base regulator and an osmotic pressure buffer agent, wherein the viscosity of the lubricating fluid for the orthokeratology lenses is 6-30 mps. The sodium hyaluronate and eye fibronectin in the lubricating fluid promote adhesion and extension of corneal epithelial cells and accelerate adhesion and extension of the epithelial cells, so that epithelial injury, epithelial edema, corneal epithelial damage and the like of the orthokeratology lenses to eye cornea can be reduced, the shaping effect of the orthokeratology lenses on ocular surface morphology is improved, and the orthokeratology lenses are not prone to deviation; and the concentration of the atropine is relatively low, the atropine is attached to the orthokeratology lenses in the form of the lubricating fluid, the in-vivo bioavailability of the atropine is greatly improved, and the purpose of improving the curative effect of the orthokeratology lenses on controlling myopia of teenagers and children is achieved.

Description

technical field [0001] The invention relates to the technical field of eye health products, in particular to a lubricating fluid for an OK lens and an OK lens product for preventing and treating myopia. Background technique [0002] As various electronic devices such as computers, mobile phones, and electronic game consoles enter society and families, these electronic devices have brought great convenience to people's work and study, but have also caused some impact on people's eyesight. Due to the long-term use of these electronic devices, the eyes are overused, and the vision continues to weaken after a long period of overloaded work. The main symptoms are: blurred vision, dry eyes, hyperemia, and photophobia, usually accompanied by systemic symptoms, such as Difficulty concentrating, listlessness, memory loss, insomnia, emotional irritability, etc., have greatly affected people's life and health. [0003] Environmental factors and genetic factors are two important factor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/46A61K47/36A61P27/10G02C7/04
CPCA61K9/08A61K9/0048A61K31/46A61K47/36A61P27/10G02C7/04
Inventor 李大伟李文龙林天翼张浙南王富成林建华
Owner 上海阿尔福斯医药科技有限公司
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