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System and method for detecting cognitive decline using speech analysis

A cognitive decline, speech technology, applied in speech analysis, nuclear methods, speech recognition, etc., can solve problems such as increased risk, non-compliance with dementia diagnosis guidelines, etc.

Pending Publication Date: 2021-11-26
JANSSEN PHARMA NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The changes caused by MCI have not been severe enough to affect daily life, and people with MCI may not meet diagnostic guidelines for dementia
However, those with MCI are at increased risk of eventually developing Alzheimer's disease (AD) or another type of dementia

Method used

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  • System and method for detecting cognitive decline using speech analysis
  • System and method for detecting cognitive decline using speech analysis
  • System and method for detecting cognitive decline using speech analysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0046] In Example 1, the exemplary vocabulary recall test was administered manually by an examiner (similar to that of the RAVLT test) and was also administered via a computer device to a total of 106 patients, of whom 84 were normal patients and 22 patients suffered from MCI. Each of the patients is provided with a first set of instructions for listening to the first list of words and immediately recalling and speaking the first list of words. The first vocabulary list includes the following words: drum, helmet, music, coffee, school, parent, machine, garden, radio, farmer, nose, sailor, color, house, river. The speech of each patient was recorded to generate a baseline speech dataset corresponding to the speech recordings. Presentation and immediate recall of the first vocabulary was repeated a total of 5 times for the entire patient group to generate 5 different baseline speech datasets.

[0047] The patient is then subjected to a distraction task. Specifically, each pat...

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PUM

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Abstract

The invention discloses a system and method for detecting cognitive decline in a subject using a classification system for detecting cognitive decline in the subject based on a speech sample. The classification system is trained using speech data corresponding to audio recordings of speech from normal and cognitive decline patients to generate an ensemble classifier comprising an ensemble module and a plurality of component classifiers. Each of the plurality of component classifiers is a machine-learning classifier configured to generate a component output identifying a sample data as corresponding to a normal patient or a cognitive patient. The machine-learning classifier is generated based on a subset of available features. The ensemble module receives component outputs from all of the component classifiers and generates an ensemble output identifying the sample data as corresponding to a normal or cognitive decline patient based on the component outputs.

Description

[0001] priority statement [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 834,170, filed April 15, 2019, entitled "System and Method for Predicting Cognitive Decline," which is hereby incorporated by reference in its entirety. Background technique [0003] Mild cognitive impairment (MCI) results in a slight but noticeable and measurable decline in cognitive abilities, including memory and thinking skills. The changes caused by MCI have not been severe enough to affect daily life, and a person with MCI may not meet diagnostic guidelines for dementia. However, those with MCI are at increased risk of eventually developing Alzheimer's disease (AD) or another type of dementia. Early therapeutic intervention provides better prospects for success. [0004] Episodic memory is the memory of an event, or "episode." It includes either a direct (newly encountered information) component or a retrograde (past event) component. Verbal episodic mem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/4803A61B5/4088A61B5/7267G10L15/08G10L15/063G06N20/10G10L2015/0631
Inventor V·纳拉扬S·瓦拉万
Owner JANSSEN PHARMA NV
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