61 results about "Cognitive regression" patented technology

The invention provides a composition beneficial to improvement of brain cognition, memory and sleep and prevention and improvement of Alzheimer's disease, and belongs to the technical field of health food. The composition comprises L-alpha-glycerophosphorylcholine (GPC), phosphatidylserine (PS), docosahexaenoic acid (DHA), tea leaf theanine (L-theanine), vitamin B groups, vitamin D3 and the like, and is prepared into a health care product, a dietary supplement, a functional food, a medical food or a nutritional supplement by adopting the existing technology. The traditional Chinese medicine composition has the effects of effectively nourishing nerve cells, improving the brain sensitivity and improving the cognitive function. The composition is particularly directed at age-related cognitive decline and neurodegenerative diseases. Repair and regeneration of nerve cells can be promoted, the transmission efficiency of neural signals is enhanced, and the overall working efficiency of the brain is improved. Daily life challenges caused by cognitive decline can be relieved, and individual life quality can be improved.

The invention relates to the technical field of cognitive data processing, in particular to a physical stimulation driven lymphatic circulation and cognitive improvement method and system. The system comprises a physical stimulation frequency influence evaluation module, a stimulation mechanical vibration analysis module, a lymph circulation vibration calibration module and a stimulation frequency drive adjustment module. A pressure sensor and a temperature sensor can be used for monitoring corresponding physical stimulation pressure and stimulation skin surface temperature in real time and performing stimulation frequency influence evaluation and stimulation mechanical vibration analysis so as to generate a physical stimulation mechanical vibration effect; and acquiring a lymph circulation velocity and an electroencephalogram neural activity signal, performing neurocognitive level analysis and vibration response calibration, and performing lymphatic circulation cognitive regression analysis and stimulation frequency driving adjustment at the same time, so as to generate a physical stimulation frequency driving adjustment scheme corresponding to lymphatic circulation cognitive improvement. According to the method, the incidence relation among physical stimulation, lymphatic circulation and cognitive promotion can be accurately analyzed.

The invention discloses a cognitive disorder progress trend prediction method based on multi-modal data fusion, which comprises the following steps: firstly, acquiring MR I images, PET images, EEG and scale information which comprises clinical cognitive score data, patient age, intelligence quotient score, gender and education degree, and carrying out standardization processing; a feature extraction network composed of a generator and a discriminator is constructed, the MRI image serves as input, high-quality PET image features are generated through the generator, the generated PET image features and real PET image features are discriminated through the discriminator, and then the generator is optimized; constructing an enhanced multi-modal classification model, and performing deep fusion on the MR I image, the generated PET image features, the EEG signals and the clinical cognitive scores to obtain multi-modal features; and 4, inputting multi-modal features, carrying out time sequence modeling by adopting a Mamba model, and predicting the cognitive decline trend of the patient in a future time period.

The invention belongs to the field of intelligent interaction equipment, and particularly relates to cognitive decline old people intelligent interaction equipment based on AR glasses, which comprises an AR glasses module, an intelligent interaction equipment module and a cloud server module, and the AR glasses module, the intelligent interaction equipment module and the cloud server module carry out real-time data exchange and synchronization through a wireless communication technology. The cloud server module comprises a user interface, a core processing unit, a family member end collaborative management applet and a nursing management module, the nursing management module comprises a nursing closed-loop management module, and eight modules of health management, cognition activation, emotion activation, diet activation, exercise activation, social activation, barrier-free interaction and nursing closed-loop management are combined. All-around intervention is provided for patients with mild cognitive impairment and Alzheimer's disease, cognitive decline is delayed, and the life quality is improved.

A method of treating cognitive decline and / or memory deficits in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one agent that directly or indirectly increases Ptprd activity and / or decreases Aβ induced inhibition of Ptprd activity in the subject.

The invention relates to the technical field of medical information processing, in particular to a cerebral apoplexy cognitive impairment risk auxiliary assessment method and a cerebral apoplexy cognitive impairment risk auxiliary assessment system. According to the method, various monitoring time sequence data and the average diffusivity in the brain nuclear magnetic resonance image result are obtained, and dynamic changes in the data and differences among different individuals can be better adapted through adaptive segmented monitoring of the time sequence data. And determining an influence coefficient by combining the similarity between the data segments and the average diffusivity. And calculating cognitive ability decline and intervention indexes based on the change trend and influence coefficient of the data segment, and dynamically reflecting the cognitive change of the patient. The evaluation mode provides accurate data for doctors, and assists in real-time monitoring of cognitive decline and timely intervention.

The invention relates to the field of radiotherapy and, more particularly, to the use of a compound based on FMS-like tyrosine kinase 3 ligand (FLT3L) and adoptive cell therapy using dendritic cells in the prevention of cognitive damage associated with radiotherapy.

Systems and methods of the present disclosure are directed to neural stimulation via audio and visual stimulations. The combination and / or sequence of audio and visual brain stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stems from sleep deprivation. In doing so, the present systems and methods can reduce sleep fragmentation, improve sleep quality, and slow the progression of cognitive decline in a subject with Alzheimer's disease and MCI.

To provide methods for treating, preventing or delaying disorders relating to cognition, such as cognitive decline, cognitive impairment or dementia.SOLUTION: The present invention provides a method of treating, preventing or delaying development of a cognitive disorder in a patient, comprising administering an effective amount of tirzepatide, or a pharmaceutically acceptable salt thereof, to the patient once weekly.SELECTED DRAWING: None

Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for memory dysfunction, Alzheimer's disease, and cognitive decline. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in improving memory, as well as for preventing and treating memory disorders, Alzheimer's disease and cognitive decline. All the above-mentioned methods are computer assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. A universal approach in everybody, as well as a personalized approaches by gender, and by diagnosis, are disclosed.

The invention relates to the technical field of individualized cognition, in particular to an individualized cognitive decline risk prediction method and system based on multi-mode data fusion. According to the method, multi-modal longitudinal evidence-based data is integrated on the basis of a group-level pathology law, a multi-scale causal link map capable of reflecting the complete period of cognitive decline is formed, pathology time axis alignment and individualized feature normalization are achieved, the dynamic pathology process of individual specificity can be captured, and the accuracy of the pathology process is improved. By fitting individual exclusive multi-scale causal parameters and constructing a time sequence cascade digital twinborn body, forward causal simulation can be executed on multiple time scales, a cognitive decline core driving path is directly revealed, and individual risk quantification and intervention targets are generated. Detection of early hidden pathological signals, dynamic modeling of individual heterogeneity and comprehensive analysis of a multi-channel pathological mechanism are achieved, the ultra-early prediction precision of cognitive decline and individualized intervention suitability are remarkably improved, and a full-period prediction system capable of being iteratively optimized continuously is formed.

The invention provides an early biomarker for cognitive impairment of Parkinson's disease, application of the early biomarker and an intelligent analysis system for Parkinson's disease. The biomarker is a GALC gene. The intelligent analysis system for the early biomarkers of the cognitive impairment of the Parkinson's disease comprises a data integration module and a data analysis module. The data integration module is used for acquiring a gene detection result, an olfactory test score and neuroimaging data of the Parkinson's disease biomarker; and the data analysis module is used for analyzing the influence of gene variation of the Parkinson's disease biomarker on olfactory dysfunction and cognitive decline of the Parkinson's disease patient by adopting a structural equation model SEM based on the multi-modal data set. According to the application, through confluence analysis of multi-modal data, by combining genetics, neuroimaging and clinical evaluation, the rs8005172 site variation of the GALC gene is taken as an early biomarker of cognitive impairment of Parkinson's disease, so that PD patients with high cognitive decline risk can be accurately identified.

The invention relates to a composition for improving cognitive decline and application thereof, a mouse aging model is constructed through a D-galactose injection method, and then mice are randomly divided into a control group, a D-gal model group, a DHA group, and a DHA, folic acid and phosphatidylserine combined intervention group (n = 12). And testing. Test results show that the combined intervention of DHA, folic acid and phosphatidylserine has a certain improvement effect on the cognitive function of the brain of an aging model mouse, can improve the inflammatory response in hippocampus tissues and the expression conditions of neurotrophic factors and synaptic associated proteins, regulates the in-vivo antioxidant level, and has a good anti-aging effect. And the new object identification and spatial learning memory ability of the mouse is improved. Therefore, the invention provides a theoretical basis for improving cognition and realizing functional dairy product development and industrial production through combined intervention of DHA, folic acid and phosphatidylserine.

A vector for use in treating cognitive decline and / or memory deficits in a subject in need thereof includes an expression cassette that includes a nucleic acid encoding asprosin and / or an analogue thereof, operably linked to one or more regulatory elements that promote expression of the asprosin and / or an analogue thereof coding sequence, wherein the one or more regulatory elements include a nucleic acid promoter, a polyadenylation (poly(A)) tail signal, and / or posttranscriptional regulatory element.

The invention relates to the technical field of data processing, and discloses a mild cognitive impairment detection system based on multi-level data, and the system comprises a terminal device which is used for collecting physiological monitoring data, clinical narrative data and multi-modal test data of a user; the data processing module is used for performing interference identification and information purification on the multi-modal test data to generate a purified cognitive response matrix; the cognitive evaluation module is used for performing cognitive ability decoupling and group benchmarking based on the purified cognitive response matrix and outputting an individual ability level; and the closed-loop management module is used for constructing a longitudinal decline slope model based on a score sequence of individual historical multiple evaluations and carrying out risk early warning and intervention recommendation. According to the method, passive disease screening of cognitive health management is converted into an active, personalized and continuous risk monitoring and intervention process, and a powerful technical tool is provided for delaying cognitive decline.

The present disclosure describes systems and methods for non-verbal communication. Aphasia and other speech related disorders can prevent people from communicating effectively or efficiently. Without effective communication, individuals can become depressed, anxious, and / or have worsening health outcomes. Many embodiments described herein allow for communication based on eye tracking of the individual to allow more effective and efficient communication between the individual and a third party, such as a family member or caretaker. Further embodiments are capable of monitoring mental state (e.g., depression and anxiety) and / or providing early detection of health events (e.g., stroke and cognitive decline).

The invention provides a quick response type nutrient composition for a cognitive load scene. The quick response type nutrient composition is prepared from the following raw materials in parts by weight: 400 to 600 parts of L-alpha-choline alfoscerate, 0.1 to 0.4 part of pyrroloquinoline quinone disodium salt, 4 to 6 parts of blueberry anthocyanin, 4 to 6 parts of gamma-aminobutyric acid, 4 to 6 parts of L-lysine and 4 to 6 parts of L-arginine. The invention further provides a preparation method and application of the quick response type nutrient composition for the cognitive load scene. Through the synergistic effect of the six components, a nerve cell energy metabolism-neurotransmitter balance-oxidation protection three-channel synergistic mechanism is formed, through the multi-target-point synergistic effect, the prepared nutrient composition has the multiple effects of improving the cognitive decline symptom, rapidly relieving cognitive fatigue, improving the thinking agility and reducing the error rate; the method is especially suitable for a high-intensity cognitive load scene. The invention belongs to the technical field of food processing.

To provide a bath agent for improving cognitive functions or preventing cognitive decline.SOLUTION: The present invention provides a bath agent for improving cognitive functions or preventing cognitive decline which contains 1,8-cineole and is foamable.SELECTED DRAWING: Figure 1

The present invention relates to treating neurodegeneration (e.g., a neurodegenerative disorder), enhancing cognitive function, delaying or reducing cognitive decline, enhancing the metabolism, and / or improving memory in patients in need thereof, e.g., patients diagnosed with a neurodegenerative disorder or displaying one or more symptoms of a neurodegenerative disorder (e.g., declining cognitive function) by administering Pla2g2f to a subject or increasing expression of Pla2g2f in a cell of a subject.

The invention provides an application of a ratio of neutrophil to lymphocyte in preparation or screening of a cognitive disorder risk diagnostic reagent. It is found that in APOE epsilon 4 allele carriers, increase of the NLR level is related to the high onset risk of cognitive impairment of the APOE epsilon 4 allele carriers, meanwhile, obesity further increases the dementia occurrence risk of high-inflammation people, and new evidence is possibly provided for synergistically promoting dementia occurrence through metabolic disorders and peripheral inflammation. In non-APOE epsilon 4 allele carriers, the high NLR level does not increase the cognitive impairment occurrence risk of old people, and it can be seen that the influence of inflammation on cognition may be an important factor for impairment of the cognitive function of the APOE epsilon 4 allele carriers. Based on an ADNI database, it is proved through longitudinal research that peripheral inflammation plays an important role in gradual decline of the cognitive function of an APOE epsilon 4 gene carrier, the high NLR level is related to fast cognitive decline, and deposition of Alzheimer's disease neuropathology markers is promoted faster. On the other hand, the AD core pathological marker plays an important role in regulating the NLR level and cognition. The invention provides a novel cognitive impairment risk diagnosis reagent and a related device which are safe, convenient, non-invasive and economical and can be widely popularized, and the reagent and the related device have great significance in improving the early recognition rate, realizing accurate intervention and optimizing treatment decision.

The disclosure relates to compositions and methods for diagnosing, stratifying, prognosing, treating and preventing and cognitive impairment, including Alzheimer's Disease, based on the identification of disease-associated metabolic transitions.

A method for identifying pre-disposition to cognitive decline in a subject, the method comprising determining levels of: (a) omega-3 fatty acids, and vitamin D or a metabolite thereof; (b) omega-3 fatty acids, and homocysteine; (c) vitamin D or a metabolite thereof, and homocysteine; or (d) omega-3 fatty acids, vitamin D or a metabolite thereof, and homocysteine, independently in one or more samples obtained from the subject.

The invention relates to a flat-surface cognitive support and engagement material designed for use on a table, lap, or fixed surface to support cognitive engagement in individuals with mild cognitive support needs, particularly those experiencing Alzheimer's disease, dementia, and similar cognitive decline.

The invention discloses wearable equipment for cognitive training. The wearable equipment comprises a telephone watch which is worn by a patient so as to communicate with a specified contact person; a cognitive training module used for carrying out intervention cognitive training on a cognitive disease patient is embedded in one side of the interior of the telephone watch, and a voice assistant used for carrying out voice recognition and interaction so that the patient can carry out personalized cognitive training is embedded in the end, close to the cognitive training module, of the interior of the telephone watch. And the telephone watch, the cognitive training module and the voice assistant carry out information interaction with one another. The method has the advantages that cognitive training intervention can be continuously performed on the cognitive disease patient in daily life so as to delay the cognitive decline process and promote cognitive function rehabilitation.

The present disclosure provides methods for treating neurodegeneration or cognitive decline in a subject comprising administering an effective amount of catestatin (CST) or its equivalent to a subject afflicted with a neurodegenerative disease, thereby, reducing neurodegeneration or cognitive decline. Also disclosed are compositions comprising CST or its equivalent, suitable for use in the methods of the present disclosure.

This invention relates to the field of cognitive data processing technology, and more particularly to a method and system for physical stimulation-driven lymphatic circulation and cognitive enhancement. The system includes a physical stimulation frequency impact assessment module, a stimulation mechanical vibration analysis module, a lymphatic circulation vibration calibration module, and a stimulation frequency drive adjustment module. It utilizes pressure and temperature sensors to monitor the corresponding physical stimulation pressure and the surface temperature of the stimulated skin in real time, performing stimulation frequency impact assessment and stimulation mechanical vibration analysis to generate a physical stimulation mechanical vibration effect. It also acquires lymphatic fluid flow velocity and EEG neural activity signals, performing neurocognitive level analysis and vibration response calibration. Simultaneously, it performs lymphatic circulation cognitive regression analysis and stimulation frequency drive adjustment to generate a physical stimulation frequency drive adjustment scheme corresponding to lymphatic circulation cognitive enhancement. This invention can accurately analyze the correlation between physical stimulation and lymphatic circulation and cognitive enhancement.

To provide a method for predicting an asymptomatic cerebral infarction and / or decline of a cognitive function, and a method for improving accuracy of predicting a clinical risk score of the asymptomatic cerebral infarction and / or decline of a cognitive function of a subject.SOLUTION: The present invention relates to a method for determining whether a subject has experienced an asymptomatic cerebral infarction at least once. The method includes the steps of: (a) determining an amount of IGFBP7 in a sample from a subject; (b) comparing the amount determined in step (a) with a reference; and (c) determining whether the subject has experienced an asymptomatic cerebral infarction at least once. The present invention further relates to a method for predicting an asymptomatic cerebral infarction and / or decline of a cognitive function and a method for evaluating and monitoring a degree of asymptomatic small and large, non-cortical and cortical infarctions in the subject. The present invention further includes a corresponding use.SELECTED DRAWING: Figure 1

Methods for preventing or slowing the progression of cognitive impairment or preventing the development or reducing the rate of cognitive decline in a subject displaying or presenting with cognitive performance within the normal range for the subject's age. The methods comprise administering to the subject one or more of levetiracetam, brivaracetam or seletracetam, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising levetiracetam, brivaracetam or seletracetam or pharmaceutical salt thereof and a pharmaceutically acceptable carrier, a GABAA α5 receptor agonist or a pharmaceutically acceptable salt, hydrate, solvate, isomer, or polymorph thereof, a pharmaceutical composition comprising a GABAA α5 receptor agonist or a pharmaceutically acceptable salt, hydrate, solvate, isomer, or polymorph thereof, and a pharmaceutically acceptable carrier, or a combination or a composition comprising the levetiracetam, brivaracetam or seletracetam or pharmaceutical salt thereof and the GABAA α5 receptor agonist or a pharmaceutically acceptable salt, hydrate, solvate, isomer, or polymorph. In some embodiments, the subjects have one or more risk factors that are predictive for or associated with the development or progression of cognitive impairment or decline.

The present invention relates to the field of treat age-related cognitive declines. In this study, the inventors report that GPR158, which localizes at the PC, is required for OCN- dependent autophagy induction in hippocampal neurons. Consistently, the mobilization of key autophagy players by OCN in hippocampal neurons requires core PC-proteins. In aged hippocampi, neuronal PC present an abnormal morphology, correlated with a reduction of the major core ciliary proteins levels. Conversely, restoration of their levels in aged hippocampi is sufficient to improve autophagy and cognitive deficits. Lastly, they show that core PC-proteins are required to integrate the rejuvenating effects of OCN in the hippocampus, thereby ameliorating age-related cognitive deficits. Altogether, these findings demonstrate a new paradigm for the neuron / systemic milieu communication and significantly advance our understanding of the regulatory mechanism mediating the rejuvenating effects of the pro-youth blood factor, OCN, in hippocampal neurons. This study also provides the foundation for novel therapeutic strategies to treat age-related cognitive decline, as well as neurological deficits in ciliopathies. Thus, the present invention relates to an activator of the primary cilia (PC) for use in the restoration and / or improvement of cognitive functions in a subject in need thereof.

PDE11A4 inhibitors, and methods of using the same, are provided for treating or preventing diseases or disorder associated with cognitive decline.