Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals
A vitamin, fatty acid technology, applied in the active agent of slowing or preventing cognitive decline, identifying the field of cognitive decline tendency of individuals
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Embodiment 1
[0239] The Multidomain Alzheimer's Prevention Trial (MAPT) was designed to evaluate the efficacy of the following compared with placebo in reducing the rate of cognitive decline in adults 70 years of age or older: omega-3 supplementation ( DHA800mg per day, EPA 200), multi-domain intervention (nutritional counseling, physical exercise, cognitive stimulation) or a combination of supplements + multi-domain. Post hoc analyzes of MAPT results indicated that ω3 supplementation prevented cognitive decline in individuals with lower ω3 status at baseline. The VITACOG trial showed that homocysteine-lowering B vitamins reduced overall brain atrophy in individuals aged 70 years and older with MCI and hyperhomocysteinemia. Two consecutive post hoc reports by VITACOG showed that the effects of B vitamins on overall brain atrophy and cognitive decline were most pronounced in individuals in the highest tertile of baseline omega 3 status. Baseline nutritional status and nutrient interactions...
Embodiment 2
[0267] The following non-limiting examples are illustrative of compositions of embodiments provided by the present disclosure for reducing cognitive aging in non-demented individuals.
[0268] Element dose / day DHA 770mg EPA 700mg Vitamin B1 (thiamine) 50mg Vitamin B2 (riboflavin) 15mg Vitamin B3 (niacin) 25mg Vitamin B5 (pantothenic acid) 23mg Vitamin B6 (pyridoxine) 18mg Vitamin B7 (Biotin) 0.15mg Vitamin B9 (anhydrous folic acid) 0.4mg Vitamin B12 (cobalamin) About 12 to 21 times the RDA of vitamin B12 Vitamin C 500mg Vitamin D 0.015mg Vitamin E 82.6mg selenium 0.08mg Citrulline 3000mg Choline bitartrate 85mg
[0269] The following numbered paragraphs further describe the invention:
[0270] 1. A method of reducing, treating or preventing cognitive aging in a non-demented individual in need thereof or at risk, the method comprising administering to t...
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