Penetrant based on tetrahydropiperine cyclodextrin inclusion compound and preparation method of penetrant

A technology of cyclodextrin inclusion complex and tetrahydropiperine is applied in the field of penetrants, which can solve the problems of poor application, poor water solubility, irritation and the like, and achieve the effects of reducing direct irritation and improving penetration effect.

Pending Publication Date: 2021-11-30
爱西美(珠海)生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tetrahydropiperine has certain irritation to the skin, has a sense of heat when used, and has poor water solubility, so its application in cosmetic formulations has limitations, and it is not widely used at present.

Method used

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  • Penetrant based on tetrahydropiperine cyclodextrin inclusion compound and preparation method of penetrant
  • Penetrant based on tetrahydropiperine cyclodextrin inclusion compound and preparation method of penetrant
  • Penetrant based on tetrahydropiperine cyclodextrin inclusion compound and preparation method of penetrant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The present invention provides a penetrant based on tetrahydropiperine cyclodextrin inclusion compound, which comprises the following components in terms of mass percentage: butanediol, glycerin, betaine, tetrahydropiperine cyclodextrin inclusion compound, Hydrolyzed chitin, inositol and polylysine, tetrahydropiperine cyclodextrin inclusion compound includes tetrahydropiperine and hydroxypropyl cyclodextrin, the weight ratio of tetrahydropiperine and hydroxypropyl cyclodextrin is 1:10.

[0029] Specifically, the inclusion compound solution of tetrahydropiperine cyclodextrin is 21.9 parts, wherein 10 parts of hydroxypropyl cyclodextrin and 1 part of tetrahydropiperine. Butylene glycol has 50 parts, glycerin has 10 parts, betaine has 10 parts, hydrolyzed chitin has 4 parts, inositol has 4 parts, and polylysine has 0.1 parts.

[0030] The present invention also provides a kind of preparation method of the penetration agent based on tetrahydropiperine cyclodextrin inclusio...

Embodiment 2

[0037] The present invention provides a penetrant based on tetrahydropiperine cyclodextrin inclusion compound, which comprises the following components in terms of mass percentage: butanediol, glycerin, betaine, tetrahydropiperine cyclodextrin inclusion compound, Hydrolyzed chitin, inositol and polylysine, tetrahydropiperine cyclodextrin inclusion compound includes tetrahydropiperine and hydroxypropyl cyclodextrin, the weight ratio of tetrahydropiperine and hydroxypropyl cyclodextrin is 1:10.

[0038] Specifically, the inclusion complex solution of tetrahydropiperine cyclodextrin is 45.95 parts, wherein hydroxypropyl cyclodextrin has 10 parts, and tetrahydropiperine has 1 part. Butylene glycol has 40 parts, glycerin has 5 parts, betaine has 5 parts, hydrolyzed chitin has 2 parts, inositol has 2 parts, polylysine has 0.05 parts.

[0039] The present invention also provides a kind of preparation method of the penetration agent based on tetrahydropiperine cyclodextrin inclusion ...

Embodiment 3

[0046] The present invention provides a penetrant based on tetrahydropiperine cyclodextrin inclusion compound, which comprises the following components in terms of mass percentage: butanediol, glycerin, betaine, tetrahydropiperine cyclodextrin inclusion compound, Hydrolyzed chitin, inositol and polylysine, tetrahydropiperine cyclodextrin inclusion compound includes tetrahydropiperine and hydroxypropyl cyclodextrin, the weight ratio of tetrahydropiperine and hydroxypropyl cyclodextrin is 1:10.

[0047] Specifically, the inclusion complex solution of tetrahydropiperine cyclodextrin is 35.92 parts, wherein 10 parts of hydroxypropyl cyclodextrin and 1 part of tetrahydropiperine. Butylene glycol has 45 parts, glycerin has 6 parts, betaine has 7 parts, hydrolyzed chitin has 3 parts, inositol has 3 parts, and polylysine has 0.08 parts.

[0048] The present invention also provides a kind of preparation method of the penetration agent based on tetrahydropiperine cyclodextrin inclusion...

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Abstract

The invention relates to a penetrant based on a tetrahydropiperine cyclodextrin inclusion compound and a preparation method of the penetrant. The penetrant comprises the following components: butanediol, glycerol, betaine, a tetrahydropiperine cyclodextrin inclusion compound, hydrolyzed chitosan, inositol and polylysine, the tetrahydropiperine cyclodextrin inclusion compound comprises tetrahydropiperine and cyclodextrin, and a weight ratio of the tetrahydropiperine to the cyclodextrin is 1: (1.0-10). The preparation method of the penetrant comprises the following steps: preparing a cyclodextrin solution, adding cyclodextrin into water, heating and stirring to fully dissolve the cyclodextrin so as to prepare a hydroxypropyl cyclodextrin solution; adding tetrahydropiperine into the hydroxypropyl cyclodextrin solution, heating and stirring at 40-60 DEG C, and completely dissolving tetrahydropiperine into the hydroxypropyl cyclodextrin solution by using ultrasonic dispersion; and continuously stirring for 2-10 hours, so that the tetrahydropiperine is fully embedded by the hydroxypropyl cyclodextrin. A penetration enhancing effect of the penetrant provided by the invention is better than that of tetrahydropiperine which is simply embedded by cyclodextrin.

Description

technical field [0001] The invention belongs to the technical field of penetrants, and in particular relates to a penetrant based on tetrahydropiperine cyclodextrin inclusion compound and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body and the most direct route of drug delivery. In the field of medicine, skin drug delivery has many unique advantages compared with other drug delivery routes, including avoiding the first-pass effect, directly acting on local lesion sites, slow-release drug delivery and controllable drug release rate, and patient treatment compliance so wait. Skin drug delivery is the most challenging non-invasive drug delivery route, and it is also the most promising alternative to injection drug delivery to deliver drug ingredients to the lesion. On the other hand, in the field of medical cosmetology, skin has always been the object of human protection and beautification. With the growth of age, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/88A61K8/34A61K8/44A61K8/49A61K8/73A61Q19/00
CPCA61K8/4973A61K8/345A61K8/44A61K8/738A61K8/736A61K8/88A61Q19/00A61K2800/56
Inventor 林助凤侯彦辉
Owner 爱西美(珠海)生物技术有限公司
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