Branched polyamino acid bacteriostatic agent and application thereof

A polyamino acid, bacteriostatic technology, applied in the application, bactericide, antifungal and other directions, to achieve the effect of good biocompatibility

Pending Publication Date: 2021-11-30
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of branched polyamino acid in the antibacterial field has not been reported so far

Method used

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  • Branched polyamino acid bacteriostatic agent and application thereof
  • Branched polyamino acid bacteriostatic agent and application thereof
  • Branched polyamino acid bacteriostatic agent and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Add 100 grams of arginine into a 500mL round-bottomed flask, connect the water separator, pump nitrogen three times, each time for more than 10 minutes, and finally keep the nitrogen atmosphere, stir and heat the reaction at 180°C for 4 hours, stop heating, and then remove the reaction system After being cooled to room temperature, the polymer was dissolved in methanol and settled in ether to obtain 82.7 grams of hyperbranched polyarginine.

Embodiment 2

[0066] Add 91.32 grams of lysine hydrochloride and 28.05 grams of KOH into a 500mL round bottom flask, connect the water separator, pump nitrogen three times, each time more than 10 minutes, and finally keep the nitrogen atmosphere, stir and heat the reaction at 250°C for 1 minute , stop heating, polymer dissolves and settles in the ether with methanol, obtains hyperbranched polylysine 84 grams.

[0067] The 1H NMR spectrum of the synthesized branched polyamino acid is as follows: figure 1 shown.

Embodiment 3

[0069] Put 50g of serine and 50mL of n-hexanol into a 500mL round bottom flask, connect the water separation device, under nitrogen atmosphere, stir and heat at 190°C for 10h, stop heating, then cool the reaction system to room temperature, polymer with methanol Dissolve and settle in ether to obtain 28.5 grams of hyperbranched polyserine.

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Abstract

The invention provides a branched polyamino acid bacteriostatic agent and application thereof. The branched polyamino acid bacteriostatic agent comprises branched polyamino acid, wherein the branched polyamino acid is obtained by homopolymerizing an amino acid unit, and the amino acid unit has a structure as shown in a formula I or a salt thereof. The raw material used in the invention is amino acid which is a natural biological material, has no toxicity and no side effect, so the branched polyamino acid bacteriostatic agent is a green and environment-friendly novel bacteriostatic agent and is easy to accept by a user. The branched structure of polyamino acid enables the agent to have many active functional groups, can be further modified and has good biocompatibility; and bacteriostatic agent can tear bacterial membranes to cause death of bacterial membranes and cannot generate drug resistance after long-term use.

Description

[0001] This application is a divisional application with application number 201810096212.2, application date January 31, 2018, and invention title "a branched polyamino acid antibacterial agent and its application". technical field [0002] The invention relates to the technical field of antibacterial agents, in particular to a branched polyamino acid antibacterial agent and its application. Background technique [0003] The invention of antibiotics has saved the lives of hundreds of millions of people and saved human beings from the pain of bacterial infection. It can be said to be a revolution in medicine. However, with the abuse of small molecule antibiotics, coupled with the short life cycle of bacteria and the characteristics of horizontal gene transfer, various drug-resistant bacteria have emerged. The spread of pathogenic bacteria is a serious threat to people's normal life. If left unchecked, superbugs could kill around 10 million people a year by 2050, according to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/10C08G69/16C08G69/48A01N37/46A01N47/44A61K31/785A61K31/787A01P1/00A01P3/00A61P31/04A61P31/10A61K8/88A61Q19/00A23L3/3526A23L3/3535A23L3/3544
CPCA61Q19/00A01N37/46A01N47/44A23L3/3526A23L3/3535A23L3/3544A61K8/88A61K31/785A61K31/787C08G69/10C08G69/16C08G69/48A61K2800/10A61K2800/524
Inventor 季生象刘骁韩苗苗刘亚栋郭建伟
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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