Liver-protecting rhizoma curcumae longae soft capsule and preparation method thereof

A technology of soft capsules and liver turmeric, applied in the field of liver-protecting turmeric soft capsules and its preparation, can solve the problems of difficult absorption, low bioavailability, insoluble in water and oil of turmeric, etc., so as to improve utilization and bioabsorption Effect

Pending Publication Date: 2021-12-10
上海互众药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to improve the utilization rate of turmeric, turmeric oil and curcumin are usually extracted from turmeric, and curcumin is an alcohol-soluble diphenylheptane compound, insoluble in water and oil, slightly soluble in ether and benzene, and soluble when heated. is higher than ethanol, so the turmeric extract has strict requirements on the extraction conditions, resulting in high extraction cost and low extraction rate
Due to the low extraction rate of turmeric extract, the traditional technology adopts the method of making turmeric into powder to solve the above problems. Generally, turmeric powder is composed of turmeric, vegetable oil, beeswax and phospholipids, and phospholipids play an emulsifying role, so that turmeric can be larger Dispersed in water and oil to a certain extent, thus solving the problem that turmeric is insoluble in water and oil
[0004] Making turmeric into powder can solve the problem of turmeric being insoluble in water and oil, but curcumin has the characteristics of poor stability, difficult oral absorption, easy metabolism, and low bioavailability. The powder can be swallowed directly or dissolved in water before drinking. Curcumin is hydrolyzed and destroyed in gastrointestinal juice or metabolized by enzymes in gastrointestinal mucosal cells, and the hydrolysis products and metabolites are directly excreted, resulting in a very low concentration of curcumin in the blood and low bioavailability

Method used

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  • Liver-protecting rhizoma curcumae longae soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A liver-protecting turmeric soft capsule, consisting of content and rubber, the amount of content and rubber in the preparation process is as described in Table 1, and is prepared through the following steps:

[0048] S1, Glue preparation:

[0049] A, according to the mass ratio of 1:20, the pectin is pre-stirred with glycerin evenly, and then according to the mass ratio of 1:10, the purified water is stirred evenly; according to the mass ratio of 1:1, the starch is pre-stirred with the purified water; according to the mass ratio of 1: 10 Stir and dissolve aspartame with purified water in advance;

[0050] B. Put the remaining purified water, glycerin and sorbitol used in step A into the colloidal sol tank for mixing, stir and heat to 88°C, then put in gelatin, continue stirring for 10min, and then put in the pectin, starch, Aspartame, continue to stir and heat up to 92°C, keep it warm for 20 minutes to sterilize, then vacuumize and defoam at -0.02MPa for 15 minutes, f...

Embodiment 2

[0059] A liver-protecting turmeric soft capsule, which consists of contents and a rubber skin, the preparation steps of which are the same as in Example 1, the difference from Example 1 is that each component and its corresponding quality are shown in Table 1.

[0060] The total weight of the liver-protecting turmeric soft capsule after drying is 1300mg / capsule, wherein the weight of the content is 555mg / capsule, the weight of the rubber skin is 745mg / capsule, and the weight of curcumin is 150mg / capsule.

Embodiment 3

[0062] A liver-protecting turmeric soft capsule, which consists of contents and a rubber skin, the preparation steps of which are the same as in Example 1, the difference from Example 1 is that each component and its corresponding quality are shown in Table 1.

[0063] The total weight of the liver-protecting turmeric soft capsule after drying is 1300mg / capsule, wherein the weight of the content is 510mg / capsule, the weight of the rubber skin is 790mg / capsule, and the weight of curcumin is 150mg / capsule.

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Abstract

The invention relates to the technical field of special medical foods, and particularly discloses a liver-protecting rhizoma curcumae longae soft capsule and a preparation method thereof. According to the technical key points, the liver-protecting rhizoma curcumae longae soft capsule consists of content and a capsule shell; the content consists of the following components of rhizoma curcumae longae, a Tween surfactant, MCT oil and ginger oil; and the mass ratio of the Tween surfactant to the MCT oil to the ginger oil is 1: 1: (5-7). According to the application, the Tween surfactant and the MCT oil are compounded to serve as an emulsifier, so that the rhizoma curcumae longae can be completely dissolved in water and intestinal juice, and the biological absorbance of the rhizoma curcumae longae is greatly improved.

Description

technical field [0001] The application relates to the technical field of special medical food, more specifically, it relates to a liver-protecting turmeric soft capsule and a preparation method thereof. Background technique [0002] Turmeric is the rhizome of Curcuma longa, a plant of the genus Curcuma longa in the family Zingiberaceae. It is a medicinal and edible plant and is known as "the health star of the 21st century". Turmeric has more physiological activities, such as lowering blood fat, anti-inflammation, protecting liver and gallbladder, anti-oxidation, hangover and other effects. The active ingredients that can be extracted from plant turmeric are curcumin and turmeric oil. Turmeric oil is an oily substance with an aromatic smell. The main components are terpenoids such as curcumene and aromatic curcumone. anti-tumor effect. Curcumin is a phenolic pigment with a wide range of biological activities. Curcumin can improve liver function, help the liver detoxify, re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/26A61K47/14A61K47/44A61K36/9066A61P3/06A61P29/00A61P1/16A61P39/06A61P39/02A61P31/02A61P35/00
CPCA61K9/4858A61K9/4875A61K36/9066A61P3/06A61P29/00A61P1/16A61P39/06A61P39/02A61P31/02A61P35/00
Inventor 刘俊胡波
Owner 上海互众药业有限公司
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