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Application of rhizoma dryopteris crassirhizomae extract in prevention and treatment of toxoplasmosis

A technology of toxoplasmosis and extract, which is applied in the field of medicine, can solve the problems such as the use of Toxoplasma gondii that has not been seen in Northeast China, and achieve the effects of avoiding toxic and side effects, lower cost, and avoiding the death of poultry and livestock

Pending Publication Date: 2022-02-11
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no use of Dongbei Guanzhong to control Toxoplasma gondii

Method used

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  • Application of rhizoma dryopteris crassirhizomae extract in prevention and treatment of toxoplasmosis
  • Application of rhizoma dryopteris crassirhizomae extract in prevention and treatment of toxoplasmosis
  • Application of rhizoma dryopteris crassirhizomae extract in prevention and treatment of toxoplasmosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of Northeast Rhizome Extract

[0026] Grind 100 g of dried Dongbei Guanzhong and pass through a 60-mesh sieve, add 8 times the amount of water to the sieved material, soak at 25 °C for 7 h, and extract continuously for 3 times. Then combine the extracts, filter, recover ethanol, and concentrate under reduced pressure to obtain the extract of Dongbei Guanzhong extract. The obtained extract is then extracted with n-hexane, chloroform, ethyl acetate and n-butanol to obtain the Northeast Guanzhong water, n-hexane, chloroform, ethyl acetate and n-butanol extract.

Embodiment 2

[0027] Example 2 Preparation of Dongbei Guanzhong Extract

[0028] Grind 200 g of Dongbei Guanzhong and pass through a 100-mesh sieve, add 5 times the amount of water to the sieved material, soak at room temperature for 5 hours, then reflux at 85°C for 2 hours, and extract continuously for 3 times. Then combine the extracts, filter, recover ethanol, and concentrate under reduced pressure to obtain the extract of Dongbei Guanzhong extract. The obtained extract is then extracted with n-hexane, chloroform, ethyl acetate and n-butanol to obtain the Northeast Guanzhong water, n-hexane, chloroform, ethyl acetate and n-butanol extract.

Embodiment 3

[0030] In order to demonstrate the anti-toxoplasma gondii and liver-protecting efficacy of the present invention, the present invention selected Example 1 to carry out a mouse test.

[0031] 1. Experimental process

[0032] Fifteen healthy female Kunming mice aged 6-8 weeks were randomly divided into 5 groups, and the mice in groups 2-5 were intraperitoneally injected with 2*10 3 Toxoplasma gondii tachyzoites. Four hours later, groups 1 and 2 were given normal saline by intragastric administration, group 3 were given 100 mg / kg spiramycin (Spi) by intragastric administration, groups 4 and 5 were given 100 mg / kg Dongbeiguanzhong extract by intragastric administration, and The food intake was consistent with other feeding conditions. After 4 days of continuous gavage, all mice were sacrificed, and all indicators were measured.

[0033] 2. Experimental results

[0034] Table 1 The inhibitory rate of Dongbei Guanzhong extract on the proliferation of tachyzoites in the peritoneal...

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Abstract

The invention discloses an application of a rhizoma dryopteris crassirhizomae extract in prevention and treatment of toxoplasmosis, namely the effective dose of the rhizoma dryopteris crassirhizomae extract in preparation of a veterinary drug for treating the toxoplasmosis of livestock or a feed for preventing and treating the toxoplasmosis is 10-200 mg / kg, the inhibition rate of the rhizoma dryopteris crassirhizomae extract on tachyzoites in the livestock infected with the toxoplasmosis is 20-90%, and the treatment indexes are all higher than 4.5. The cyrtomium fortunei extract can effectively prevent and treat the invasion of toxoplasma gondii and protect the liver, is wide in source, and is a natural and safe product.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a new application of an extract from the Northeast Rhizome in the prevention and treatment of toxoplasmosis. Background technique [0002] Livestock and poultry parasitic diseases such as schistosomiasis, pig cysticercosis, echinococcosis, trichinellosis, toxoplasmosis, cryptosporidiosis, sarcoidosis, etc. can hinder the normal growth and development of young animals and poultry. Extend the slaughter time, reduce the use ability of draft animals, and shorten the service life. Infection with parasites not only causes some of the nutrients ingested by poultry to flow to parasites, the meat increase rate of poultry and poultry decreases, resulting in serious waste of feed, but also leads to a decline in the quality of livestock products, reducing the resistance of poultry and poultry, and in severe cases, it will induce Various diseases have caused mass deaths of poul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/12A61P33/02A23K10/30A23K50/75A23K50/10A23K50/20A23K50/30A23K50/40
CPCA61K36/12A61P33/02A23K10/30A23K50/75A23K50/10A23K50/20A23K50/30A23K50/40A61K2236/331A61K2236/55
Inventor 金春梅程旭金莉莉
Owner YANBIAN UNIV
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