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Application of protein nano-selenium in preparation of medicine for preventing and treating oral diseases

An oral disease and nano-selenium technology, applied in the field of biomedicine, can solve problems such as unsuitable daily long-term care, changes in tooth surface and taste, oral ulcer hemostasis, wound repair, etc. The effect of good repair and good biocompatibility

Pending Publication Date: 2022-02-15
彭咏波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, commonly used mouthwash is mainly composed of triclosan or metronidazole, tinidazole or hydrogen peroxide or iodine solution and other components. Although these components have good bactericidal or antibacterial effects and strong irritation, they are mainly used in clinical treatment. However, it is not suitable for daily long-term care; daily mouthwash containing essential oil or chlorhexidine certified by the US FDA, chlorhexidine should not be used for a long time, it will cause dental calculus or tooth surface and taste changes; essential oil mouthwash has strong permeability, and Alcohol is harmless and has the function of refreshing breath, but it has no significant effect on the prevention and treatment of oral ulcers, dental caries, hemostasis, and wound repair.

Method used

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  • Application of protein nano-selenium in preparation of medicine for preventing and treating oral diseases
  • Application of protein nano-selenium in preparation of medicine for preventing and treating oral diseases
  • Application of protein nano-selenium in preparation of medicine for preventing and treating oral diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The preparation of embodiment 1 albumin nano selenium

[0014] According to the preparation method described in Example 1 of the Chinese patent application whose application number is 201810166924.7, the protein-bound nano-selenium element prepared is the albumin nano-selenium of this embodiment, and the obtained albumin nano-selenium particles have a uniform nanometer size. The distribution is uniform, and the average particle size is about 30-40nm.

Embodiment 2

[0015] The preparation of embodiment 2 nano-selenium mouthwash

[0016] Take 10mL of edible vinegar and 400mL of ultrapure water, mix them evenly, then add 10mL of nano-selenium, and mix well to get the nano-selenium mouthwash that can be used. Because it is easy to aggregate, it needs to be shaken before use to get the nano-selenium mouthwash. At the same time, 10 mL of nano-selenium was added to 400 mL of normal saline to prepare the nano-selenium group for the experiment.

Embodiment 3

[0017] The preparation of embodiment 3 albumin nano-selenium mouthwash

[0018] Take 10 mL of edible vinegar and 400 mL of ultrapure water, mix them evenly, then add 10 mL of albumin nano-selenium obtained in Example 1, and mix well to obtain a usable albumin nano-selenium mouthwash.

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Abstract

The invention belongs to the technical field of biological medicines, and discloses the application of protein nano-selenium in preparation of medicines for preventing and treating oral diseases. The protein nano-selenium has the effects of resisting inflammation, easing pain, stopping bleeding and repairing wounds, and can be used for preparing various medicines for preventing or treating dental ulcer, decayed teeth or halitosis, oral analgesic medicines, oral hemostatic medicines or oral wound repairing medicines.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of protein nano-selenium in the preparation of drugs for preventing and treating oral diseases. Background technique [0002] With the development of economy, life and modern medical research, oral health problems of humans and animals have been paid more and more attention. Nursing products are not limited to toothpaste, and new dental strips, dental floss, mouthwash, etc. are gradually developed. Halitosis, dental caries, and oral ulcers are common modern oral diseases, among which halitosis accounts for more than 30% in China, and more than 50% in Europe and the United States; dental caries in my country exceeds 45% on average, and more than 70% of people aged 0-18; the incidence of ulcers is more likely Frequent hair loss; these bring great pain and inconvenience to patients' daily life and work. [0003] At present, commonly used mouthwashes are mainl...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K47/42A61P1/02A61P7/04A61P29/00
CPCA61K33/04A61K47/42A61P1/02A61P7/04A61P29/00
Inventor 欧平花彭琪瑶彭咏波彭麓灵杨腾罗爱民刘少清罗权陈美姿
Owner 彭咏波
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