Gradient injection containing mixed polymer microspheres

A technology of mixing polymers and injections, which is applied in the field of medical cosmetic materials, can solve the problems of short duration of effect and difficulty in achieving excellent effects, and achieve the effects of reducing usage, avoiding nodules, and ensuring safety

Pending Publication Date: 2022-03-01
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HA microspheres are easily degraded by enzymes in the human body, and this easy degradability still makes the duration of product injection

Method used

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  • Gradient injection containing mixed polymer microspheres
  • Gradient injection containing mixed polymer microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of PLLA microspheres: Dissolve 6g PLLA (average molecular weight 156kDa) in 114g methylene chloride to make a polymer solution with a mass concentration of 5%, i.e. oil phase 1; weigh 10g Tween 20 in 490g water , stirred and dissolved to prepare an aqueous solution with a mass concentration of 2%, that is, the water phase 1; add all the oil phase 1 into the water phase 1, stir and emulsify for 30 minutes, and obtain an oil-in-water emulsion; keep stirring the emulsion at 30°C for 12 hours to make Dichloromethane was completely volatilized, and centrifuged to obtain PLLA microspheres; washed with water and ethanol respectively, and vacuum-dried to obtain 5.6 g of powdery solid PLLA microspheres; the microspheres were sieved with 63 μm and 20 μm sieves respectively to obtain 20-63 μm PLLA microspheres. PLLA microspheres 4.1 g.

[0031](2) Preparation of cross-linked sodium hyaluronate microspheres: 6 g of sodium hyaluronate powder (average molecular weight...

Embodiment 2

[0034] (1) Preparation of PLLA microspheres: prepare 0.5% PLLA (average molecular weight 260kDa) methylene chloride oil phase solution 300g by the same method as in Example 1; reconfigure 5% Tween 60 water phase solution 2000g; two-phase mixing and stirring 10min, then continued to stir at 40°C for 12h to completely volatilize the dichloromethane, centrifuged to obtain PLLA microspheres, washed and vacuum-dried to obtain 1.4g of PLLA microspheres; sieved the microspheres with 85μm and 40μm sieves respectively to obtain 0.9 g of PLLA microspheres of 40-85 μm.

[0035] (2) Preparation of cross-linked sodium hyaluronate microspheres: prepare 100 g of 5% (average molecular weight 1750 kDa) sodium hyaluronate aqueous phase solution by the same method as in Example 1; then configure 5% Span 80 liquid paraffin oil phase 600 g of solution; the two phases were mixed and stirred for 5 min, and 0.2% divinyl sulfone relative to the mass of sodium hyaluronate powder was added to the emulsi...

Embodiment 3

[0038] (1) Preparation of PLLA microspheres: prepare 12% PLLA (average molecular weight 52kDa) oil phase solution 50g by the same method as in Example 1; reconfigure 1250g of aqueous phase solution of 0.5% sodium lauryl sulfate; Two-phase mixing and stirring 120min, then continued to stir at 25°C for 12h to completely volatilize the dichloromethane, centrifuged to obtain PLLA microspheres, washed and vacuum-dried to obtain 5.8g of PLLA microspheres; sieved the microspheres with 25μm and 3μm sieves respectively to obtain 3.2 g of PLLA microspheres of 3-25 μm.

[0039] (2) Preparation of cross-linked sodium hyaluronate microspheres: prepare 10 g of 30% (average molecular weight 130 kDa) sodium hyaluronate aqueous phase solution by the same method as in Example 1; 80 g of liquid paraffin oil phase solution in a plate; the two phases were mixed and stirred for 100 min, and 10% divinyl sulfone relative to the mass of sodium hyaluronate powder was added to the emulsion, and stirred ...

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Abstract

The invention provides a gradient injection containing mixed polymer microspheres. The injection is freeze-dried powder composed of a filling agent, cross-linked sodium hyaluronate microspheres, poly-L-lactic acid (PLLA) microspheres and an excipient. The powder is used for injection beauty after being mixed with sterile water, a triple gradient action effect is formed by mixing the filler, the cross-linked sodium hyaluronate microspheres and the PLLA microspheres, the subcutaneous volume of human skin can be improved, wrinkles, wrinkles, scars and aging of the skin can be repaired, the powder is also suitable for correcting large-volume facial fat loss, and the effect of beautifying the face is achieved. Adverse reactions such as nodules and granuloma are avoided.

Description

Technical field: [0001] The invention relates to a gradient injection containing mixed polymer microspheres, which belongs to the technical field of medical cosmetic materials. Background technique: [0002] There are many collagens in human skin, and the growth, repair, nutrition, elasticity and tension of skin are closely related to collagen. The aging process of the human skin is largely due to the loss of collagen—from the age of 25, the human body will begin to lose collagen, which is also the main reason for the thinning of the skin, the decrease in elasticity, and the appearance of wrinkles and fine lines in the elderly. Therefore, the fundamental method for repairing defects such as wrinkles and folds of human skin is to replenish the lost collagen. [0003] US Patent No. 6,716,251 B1 discloses an injection implant, and its product (trade name: Sculptra) has been used for dermal and subcutaneous injections to improve wrinkles and facial depressions. The main compon...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/24A61L27/50A61L27/58
CPCA61L27/20A61L27/18A61L27/24A61L27/58A61L27/50A61L2400/06C08L5/08C08L67/04C08L1/286A61L2430/34
Inventor 李杰伍飞飞周奎付洋马矢徒
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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