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Application of common turnip in preparation of medicines for relieving swelling and pain

A technology for reducing swelling and relieving pain, coriander root, applied in the direction of application, drug combination, non-central analgesic, etc., can solve the problem that the analgesic effect of coriander root has not been discovered, achieve good analgesic effect, small side effects, and wide application foreground effect

Pending Publication Date: 2022-03-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the analgesic effect of coriander root has not been discovered

Method used

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  • Application of common turnip in preparation of medicines for relieving swelling and pain
  • Application of common turnip in preparation of medicines for relieving swelling and pain
  • Application of common turnip in preparation of medicines for relieving swelling and pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of radish root water extract

[0028] The coriander root that the present invention adopts is planted in the eucalyptus in the east of the Qinghai-Tibet Plateau, with an average altitude of 4493.4m.

[0029] Cut coriander root into 3-5mm slices and air-dry in the shade for 2 weeks. According to the mass-volume ratio of coriander root and water as 1:8, heat to 100°C for reflux extraction for 2.5 hours, membrane filtration, and take the supernatant; repeat the extraction of the dregs once according to the above process to obtain the supernatant; The supernatants were combined and concentrated under reduced pressure until the solid content was 0.15 g / mL to obtain the root water extract.

experiment example 1

[0030] Experimental Example 1: Verification of the detumescence and analgesic effects of coriander root water extract

[0031] 1. Effects of diphenylmethanol on auricle swelling in mice

[0032] Take 50 male KM mice, and randomly divide them into 5 groups including blank control group, model group, low-dose fennel root extract group, high-dose fennel root extract group, and positive drug control group, with 10 mice in each group. Among them, the blank control group and the model group were given the same amount of 0.5% carboxymethyl cellulose, and the low-dose and high-dose groups were given 1 g / kg and 4 g / kg of the root extract, respectively. The recommended human dose (6g / d) in the Provincial Tibetan Medicine Standard (2020) (Sichuan Provincial Food and Drug Administration) is converted to the low dose of mice (equivalent to 10 times the human intake). The positive control group was given aspirin 300mg / kg, and it was given by gavage continuously for 7 days.

[0033] 1 hour...

Embodiment 2

[0055] The anti-tumor and analgesic composition of this embodiment includes 70 parts by weight of Yuangen water extract and 30 parts by weight of Chuanqiong water extract.

[0056] The preparation method of Radix Coriander root water extract, Chuanqiong water extract is the same as embodiment 1.

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Abstract

The invention discloses application of common turnip in preparation of swelling and pain relieving medicines. The invention discloses the analgesic effect of the common turnip for the first time. The common turnip extract has an obvious detumescence effect on mouse auricle swelling caused by xylene and rat egg white foot swelling, has a good analgesic effect on mouse pain reaction and mouse acetic acid writhing reaction in a hot plate test, and has obvious effects on adjuvant therapy and prevention and treatment of pain. Due to the medicinal and edible dual-purpose characteristic of the common turnip, the common turnip has small side effects when being used as the swelling and pain relieving medicine, and the common turnip has a wide application prospect in the swelling and pain relieving field. The common turnip extract is combined with the Sichuan lovage rhizome, the turmeric, the salvia miltiorrhiza, the motherwort herb and the herba lycopi plant extract, so that a synergistic effect can be achieved, and the effects of relieving swelling and pain are remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of development and utilization of coriander root, and in particular relates to the application of coriander root in the preparation of swelling-reducing and pain-relieving drugs. Background technique [0002] Pain is not only a symptom, but also a disease, which has become a serious public health problem worldwide and one of the most feared symptoms of many patients. Pain not only affects the quality of life, but some people will also develop mental illness due to long-term pain that cannot be effectively treated. Many pain patients, due to untimely treatment, make local long-term universal pain transform into complex local pain syndrome or central pain, becoming an intractable pain disease. Analgesic drugs play an important role in pain management. The currently commonly used analgesic drugs in clinical practice include non-steroidal anti-inflammatory drugs, opioids, NMDA receptor antagonists, local anest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A23L33/105A61K36/9066A61K36/537A61K36/533A61K36/53A61P29/00
CPCA61K36/31A23L33/105A61P29/00A61K36/236A61K36/9066A61K36/537A61K36/533A61K36/53A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2002/00A23V2250/21A23V2200/31A61K2300/00
Inventor 钱和朱红康胡斌化涵毅李兴鸣
Owner JIANGNAN UNIV
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