Ophthalmic composition of indigo carmine and ophthalmic application thereof

Abstract

An ophthalmic composition comprising indigo carmine or indigo carmine and trypan blue for identifying intraocular structures and membranes within the eye, and methods of delivering and using the ophthalmic composition for surgical treatment of the eye, including glaucoma and cataract surgery.

Description

[0001] cross reference [0002] This application claims the benefit of priority to U.S. Provisional Application No. 62 / 819,336, filed March 15, 2019, and further claims the benefit of priority to U.S. Provisional Application No. 62 / 842,164, filed May 2, 2019. Each of the aforementioned related applications is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to ophthalmic compositions comprising indigo carmine or indigo carmine and trypan blue, and methods of delivering and using said ophthalmic compositions, particularly during ocular surgical procedures, such as in the treatment of patients with glaucoma and / or A method of using the ophthalmic composition during surgery on a patient with cataract or cataract. Background technique [0004] Glaucoma is an eye disease in which inappropriate pressure (often elevated) damages retinal ganglion cells, resulting in permanent visual field loss. If left untreated, glaucoma can...

AI Technical Summary

Problems solved by technology

As a result, physicians or surgeons who diagnose or treat conditions related to, or thought to be related to, the membranes in the eye, ocular structures are hampered by the inability to properly visualize such structures

[0018] Furthermore, existing methods for judging the location and patency of outflow pathways are not well developed and are inconsistent or impractical during surgery

Reduction of intraocular pressure via puncture (a small incision through the cornea and into the anterior chamber of the eye) immediately after stent placement can lead to retrograde blood filling of Schlemm's canal (see, eg, Wirbelauer, C., et al., "Role ofIntraoperative Indirect Channelography in Glaucoma Stent Implantation", Klin.Monbl.Augenheilkd.,2017,234:1378-1386), but it is currently difficult to judge this through a 360-degree angle during surgery using available imaging systems

Although techniques using aqueous humor angiography combined with the dye indocyanine green can confirm the segmental nature of the drainage (see, eg, Huang, A.S., et al., "Aqueous Angiography: Aqueous Humor Outflow Imaging in Live Human Subjects", Ophthalmology, 2017 , 124:1249-1251), but this and other techniques require special imaging equipment (see e.g., Saraswathy, S., et al., "Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging", PLoS One, 2016 Jan 25 ,11(1):e0147176), thereby limiting access to routine surgery

The disadvantageous necessity for such techniques to use special imaging equipment may be due to the limited visibility of the dye as it passes through the drainage system

Furthermore, compared to acid dyes, which are generally less toxic in tissue interactions (see, e.g., Grant, W.M. et al., Toxicology of the Eye, 4th ed., Springfield, IL: Charles C. Thomas, 1993) , indocyanine green has another disadvantage of being a basic dye, so its use raises concerns about causing further tissue damage

[0019] Another ophthalmic dye, trypan blue, although it has been shown to be effective in identifying and visualizing ocular structures, especially the anterior capsule of the lens and the trabecular meshwork (see e.g., U.S. invalid

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