Ophthalmic composition of indigo carmine and ophthalmic application thereof

A technology of indigo carmine and composition, applied in the ophthalmic composition of indigo carmine and the field of ocular use thereof, can solve the problems of impracticality, tissue damage, obstacles to diagnosis or treatment of doctors or surgeons, etc., to reduce surgery operation, reducing the effect of organizational operations

Pending Publication Date: 2022-03-11
米纳斯希欧多尔科罗内奥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, physicians or surgeons who diagnose or treat conditions related to, or thought to be related to, the membranes in the eye, ocular structures are hampered by the inability to properly visualize such structures
[0018] Furthermore, existing methods for judging the location and patency of outflow pathways are not well developed and are inconsistent or impractical during surgery
Reduction of intraocular pressure via puncture (a small incision through the cornea and into the anterior chamber of the eye) immediately after stent placement can lead to retrograde blood filling of Schlemm's canal (see, eg, Wirbelauer, C., et al., "Role ofIntraoperative Indirect Channelography in Glaucoma Stent Implantation", Klin.Monbl.Augenheilkd.,2017,234:1378-1386), but it is currently difficult to judge this through a 360-degree angle during surgery using available imaging systems
Although techniques using aqueous humor angiography combined with the dye indocyanine green can confirm the segmental nature of the drainage (see, eg, Huang, A.S., et al., "Aqueous Angiography: Aqueo

Method used

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  • Ophthalmic composition of indigo carmine and ophthalmic application thereof
  • Ophthalmic composition of indigo carmine and ophthalmic application thereof
  • Ophthalmic composition of indigo carmine and ophthalmic application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0279] Dye solutions containing 0.004 wt%, 0.04 wt%, and 0.4 wt% indigo carmine (prepared by serial dilution of a 0.4 wt% indigo carmine solution supplied by Micro-Tech (Nanjing) Co.) followed the dye solution detailed above Instillation procedure, instilled by injection into the anterior chamber of seven eye bank eyes.

[0280] After a short delay from the start of the infusion / injection, indigo carmine dye appeared in the capillaries in the conjunctiva adjacent to the limbus, the aqueous humor veins, and the conjunctival venous system. The indigo carmine dye is readily visible to the naked eye of the surgeon as it appears on the surface of the eye into which the dye is instilled, and the detailed branching of the depicted blood vessels is visible using a standard operating microscope routinely used in glaucoma surgery (see figure 2 ). No special imaging technique is required. Indigo carmine dye was also observed in the deep plexus of the sclera once the conjunctival refle...

Embodiment 2

[0287] To study aqueous humor circulation and flow, the anterior chamber geometry was generated in a solid modeling software package (Fusion 3D). This computer model was used to study the effect of stent placement, including the effect of the amount of stent placed on various ocular properties such as aqueous humor circulation, flow velocity, and intraocular pressure. This computer model is

[0288] In the model used, the stent hole (modeled as an outlet in the computer model) was positioned and placed in the anterior chamber (see Figure 17B ) separated by 120 degrees (see Figure 17A ), and each stent hole (outlet) has a diameter of 0.3mm. Such as Figure 17A As shown, an additional hole is included as a modeling requirement (marked "X"), but this hole has no fluid interactions and no fluid flows through it. The aqueous humor fluid properties used in the computer model were taken from the literature (see Dvoriashyna, M., et al., Ocular Fluid Dynamics 2019). The resultin...

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PUM

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Abstract

An ophthalmic composition comprising indigo carmine or indigo carmine and trypan blue for identifying intraocular structures and membranes within the eye, and methods of delivering and using the ophthalmic composition for surgical treatment of the eye, including glaucoma and cataract surgery.

Description

[0001] cross reference [0002] This application claims the benefit of priority to U.S. Provisional Application No. 62 / 819,336, filed March 15, 2019, and further claims the benefit of priority to U.S. Provisional Application No. 62 / 842,164, filed May 2, 2019. Each of the aforementioned related applications is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to ophthalmic compositions comprising indigo carmine or indigo carmine and trypan blue, and methods of delivering and using said ophthalmic compositions, particularly during ocular surgical procedures, such as in the treatment of patients with glaucoma and / or A method of using the ophthalmic composition during surgery on a patient with cataract or cataract. Background technique [0004] Glaucoma is an eye disease in which inappropriate pressure (often elevated) damages retinal ganglion cells, resulting in permanent visual field loss. If left untreated, glaucoma can...

Claims

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Application Information

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IPC IPC(8): A61F9/007
CPCA61F9/007A61F9/0008A61K49/0021A61F2009/00891A61F2009/00887A61F9/00781A61K49/006A61K49/0071
Inventor 米纳斯·希欧多尔·科罗内奥
Owner 米纳斯希欧多尔科罗内奥
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