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Antibiotic and hormone combined hydrogel capable of being locally injected as well as preparation method and application

A technology for local injection and antibiotics, which is applied in the direction of local antibacterial agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of short action time, fluid loss, and repeated puncture injections, etc., to achieve Good biocompatibility and uniform drug effect

Pending Publication Date: 2022-02-08
中国人民解放军海军军医大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shortcomings of traditional liquid injection, such as liquid loss, one-time release, short action time, and the need for repeated puncture injections, it does not meet the actual clinical needs.

Method used

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  • Antibiotic and hormone combined hydrogel capable of being locally injected as well as preparation method and application
  • Antibiotic and hormone combined hydrogel capable of being locally injected as well as preparation method and application
  • Antibiotic and hormone combined hydrogel capable of being locally injected as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 provides an injectable clarithromycin hydrogel and its preparation method.

[0063] The preparation method of injectable clarithromycin hydrogel comprises the following steps:

[0064] Step 1, dissolving lecithin, cholesterol and clarithromycin (CAM) in methanol at a weight ratio of 4:1:0.2 by ultrasonic waves to obtain a first solution.

[0065] Step 2: transfer the first solution to a rotary evaporator, and perform rotary evaporation under the conditions of a rotating speed of 50 r / min and a temperature of 40° C. to obtain a honeycomb-shaped thin film at the bottom of the container.

[0066] Step 3, mixing the above-mentioned film with a preheated buffer solution with a concentration of 1×PBS, then hydrating for 2 hours at a rotation speed of 50 r / min and a temperature of 40° C., and then ultrasonicating to obtain clarithromycin liposomes, Denoted as CAM-Lips. Wherein, the thin film and the PBS buffer solution are mixed according to the mass volume rati...

Embodiment 2

[0069] Example 2 provides a locally injectable hydrogel combined with antibiotics and hormones and a preparation method thereof. Wherein, the antibiotic used in this embodiment is CAM, and the hormone is budesonide (BUD).

[0070] The preparation method of locally injectable antibiotic and hormone combined hydrogel comprises the following steps:

[0071] Step 1, dissolving lecithin, cholesterol, CAM and BUD in methanol at a weight ratio of 4:1:0.2:0.2 by ultrasonic waves to obtain a mixed solution.

[0072] Step 2: transfer the mixed solution to a rotary evaporator, and perform rotary evaporation under the conditions of a rotating speed of 50 r / min and a temperature of 40° C. to obtain a honeycomb-shaped thin film at the bottom of the container.

[0073] Step 3, mixing the above film with preheated 1×PBS buffer solution, then hydrating for 2 hours under the conditions of rotating speed of 50r / min and temperature of 40°C, and then ultrasonicating to obtain liposomes for combin...

Embodiment 3

[0076] Embodiment 2 provides a kind of locally injectable hydrogel used as a control, and its preparation method is as follows:

[0077] Dissolve 4-ARM-PEG powder in deionized water and add 0.05M AgNO 3 The solution is mixed to obtain a clear, injectable hydrogel, referred to as Pure Hydrogel. Wherein, the purity of 4-ARM-PEG powder is 96%, the molecular weight is 10kDa, and the mass volume ratio of 4-ARM-PEG powder to deionized water is 1 mg:10 μl. Deionized water and AgNO 3 The volume ratio of the solution is 1:1.

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Abstract

The invention provides an antibiotic and hormone combined hydrogel capable of being locally injected as well as a preparation method and application, and belongs to the field of nasosinusitis treatment. The preparation method of the antibiotic and hormone combined hydrogel capable of being locally injected comprises the following steps: 1, dissolving lecithin, cholesterol, antibiotics and hormones in methanol by using ultrasonic waves according to a weight ratio of 4:1:0.2:0.2 to obtain a mixed solution; 2, carrying out rotary evaporation on the mixed solution to obtain a honeycomb-shaped film; 3, subjecting the film and a preheated PBS buffer solution to hydration and ultrasonic treatment to obtain the antibiotic and hormone combined lipidosome; and 4, dissolving four-arm sulfydryl polyethylene glycol powder in the antibiotic and hormone combined liposome, adding an AgNO3 solution, and conducting mixing to obtain the transparent antibiotic and hormone combined hydrogel capable of being locally injected.

Description

technical field [0001] The invention relates to the field of sinusitis treatment, in particular to a locally injectable hydrogel combined with antibiotics and hormones, a preparation method and application thereof. Background technique [0002] The incidence of chronic rhinosinusitis (CRS) and acute rhinosinusitis (ARS) is high, and the number of cases in the United States reaches 31 million every year, of which 50,000 people undergo surgical treatment due to CRS [1] . According to the "National Health Survey Report" released by the former Ministry of Health in 2013, the number of patients with various types of acute and chronic sinusitis reached about 350 million. A further specialist survey found that the overall prevalence of CRS in the Chinese population was 8%. [2] , The resulting decline in the quality of life of patients and social harm is very huge. [0003] At present, the treatment methods for CRS mainly include antibacterial, hormonal drug therapy and surgical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7048A61K47/20A61P11/02A61P29/00A61P31/02A61P31/04A61K31/58
CPCA61K31/7048A61K31/58A61K9/06A61K9/0024A61K9/0043A61K47/20A61P11/02A61P31/02A61P31/04A61P29/00A61K2300/00
Inventor 唐海红崔文国陈争明郑宏良
Owner 中国人民解放军海军军医大学第一附属医院
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