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Antibacterial polypeptide compound, medical device, hydrogel and application of antibacterial polypeptide compound

An antibacterial polypeptide and compound technology, applied in the field of biochemistry, can solve the problems of low antibacterial activity, limited application, low bioavailability, etc., and achieve the effect of high antibacterial activity, avoiding adhesion and residue, and high bioavailability

Pending Publication Date: 2022-03-15
GUANGZHOU TOWE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, antimicrobial peptide J-1, like other natural antimicrobial peptides, has disadvantages such as low antibacterial activity and low bioavailability, which severely limit its application (Peptides, 2019, 112:56-66)

Method used

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  • Antibacterial polypeptide compound, medical device, hydrogel and application of antibacterial polypeptide compound
  • Antibacterial polypeptide compound, medical device, hydrogel and application of antibacterial polypeptide compound
  • Antibacterial polypeptide compound, medical device, hydrogel and application of antibacterial polypeptide compound

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Embodiment Construction

[0098]The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention. The instruments used in the present invention include: the high performance liquid chromatograph is the Delta 600 type of American waters company, the used preparation column is a reversed-phase C18 column (XBridgeBEH 130Prep), 19mm*250mm; the analytical column is a reversed-phase C8 column, 4.6mm*250mm The mass spectrometer is BrukerMaxis 4G mass spectrometer; the reagents used include: the resin is Rink-amide-MBHA-resin of Tianjin Nankai Hecheng Company (substitution value is 0.43mol / g, 200-400 mesh); N-A-Fmoc protected amino acids, N-Hydroxybenzotriazole (HOBt), Oxy-benzotriazole-N,N,N',N'-tetramethylurea-hexafluorophosphate (HBTU), diisopropylethylamine ( DIEA) and t...

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PUM

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Abstract

The invention discloses an antibacterial polypeptide compound, a medical device, hydrogel and application thereof. The antibacterial polypeptide compound has high antibacterial activity, high enzymolysis stability, high bioavailability and low cytotoxicity. The hydrogel does not adhere to wounds, has antibacterial activity and hemostatic performance, and can be used for drug entrapment and slow release, for example, anti-inflammatory drugs or epidermal growth factors, angiogenesis factors and the like can be loaded, wound healing is accelerated, and formation of scar tissue fibers is reduced. Meanwhile, the preparation method of the hydrogel is few in process steps, simple in raw material variety and convenient to operate.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, and relates to an antibacterial polypeptide compound, in particular to an antibacterial polypeptide compound that can be used for antibacterial and hemostasis, a hydrogel and its application, and a medical device suitable for the antibacterial polypeptide compound or the hydrogel. Background technique [0002] With the overuse and abuse of antibiotics in the medical, agricultural and food industries, it has led to an alarming increase in bacterial resistance to antibiotics, greatly reducing the therapeutic effect of existing antibiotics, and seriously threatening global public health and human life. At present, about 700,000 deaths worldwide are caused by drug-resistant bacterial infections each year. It is estimated that by 2050, 10 million people will die each year due to this, and the economic loss will exceed trillions of dollars. WHO has identified the problem of bacterial resistance as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C08J3/075A61K9/06A61K47/42A61L26/00A61L31/04A61L31/10A61L31/14A61L31/16A61P41/00A61K45/00A61K38/18
CPCC07K7/06C08J3/075A61K9/06A61K47/42A61K45/00A61K9/0014A61K9/006A61K9/0034A61K38/18A61P41/00A61L26/008A61L26/0047A61L26/0066A61L31/10A61L31/145A61L31/16A61L31/047C08J2389/00A61L2300/404A61L2300/414A61L2300/41C08L89/00
Inventor 李悦
Owner GUANGZHOU TOWE BIOTECH CO LTD
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