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Povidone iodine temperature-sensitive gel preparation

A technology of povidone-iodine temperature-sensitive gel and temperature-sensitive gel, which is applied in the direction of aerosol delivery, medical preparations of non-active ingredients, active ingredients of synthetic polymer materials, etc., and can solve the problem of povidone-iodine and poloxamer Incompatibility and other issues, to achieve the effect of convenient drug use, increased bioavailability and good drug efficacy for patients

Pending Publication Date: 2022-03-22
IVEW THERAPEUTICS (ZHUHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a solution for the incompatibility of povidone-iodine and poloxamer, so that the two can be compatible without affecting the efficacy and temperature-sensitive properties, and finally prepared into a Povidone-iodine temperature-sensitive gel preparation with good spreadability, large coverage, long residence time, good drug effect, small side effects, and convenient medication for patients

Method used

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  • Povidone iodine temperature-sensitive gel preparation
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  • Povidone iodine temperature-sensitive gel preparation

Examples

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Effect test

Embodiment 1

[0022] The technical solution of the present invention will be further described in detail through specific examples below. Example 1: Preparation and investigation of poloxamer thermosensitive gel.

[0023] Poloxamer thermosensitive gel formula (100g) is as follows: Poloxamer (407) 15g, Poloxamer (188) 20g, purified water 65g.

[0024] The preparation method is as follows:

[0025] (1) Weigh the prescribed amount of purified water into a beaker, place the beaker in an ice bath, put it in a stirrer and stir.

[0026] (2) Weigh the prescribed amount of poloxamer (P188, P407) and slowly add it into the beaker until it is stirred and dissolved, and the sample 1 of the embodiment is obtained.

[0027] Investigate the thermosensitive characteristic of embodiment sample 1, the results are shown in Table 1:

[0028] Table 1

[0029]

[0030] From the results in Table 1, it can be seen that under the given type and dosage conditions, poloxamer can show obvious thermosensitive g...

Embodiment 2

[0031] Example 2: Preparation and investigation of povidone-iodine thermosensitive gel.

[0032] The prescription of 2% povidone-iodine thermosensitive gel is as follows: povidone-iodine 2g, poloxamer (407) 15g, poloxamer (188) 20g, add purified water to 100g.

[0033] The preparation method is as follows:

[0034] (1) Take purified water into a beaker according to the prescription, place the beaker in an ice bath, put in a stirrer and stir;

[0035] (2) Take the povidone-iodine of prescription quantity, slowly join in the beaker, stir until dissolving completely;

[0036] (3) Weigh the prescribed amount of poloxamer (P188, P407) and slowly add it into the beaker until it is stirred and dissolved, and the sample of Example 2 is obtained.

[0037] Investigate the thermosensitive characteristic of embodiment sample 2, the results are shown in Table 2:

[0038] Table 2

[0039]

[0040] It can be seen from the results in Table 2 that after the combination of povidone iodin...

Embodiment 3

[0046] Example 3: Preparation and investigation of 2% povidone-iodine (containing hydrogen peroxide) thermosensitive gel.

[0047] The prescription is as follows: Povidone iodine 2g, add 6% hydrogen peroxide 15g / 10g / 5g / 2g / 1g, poloxamer (407) 15g, poloxamer (188) 20g, add purified water to 100g. A total of 5 formulation samples are respectively Example 3 Sample 1, Example 3 Sample 2, Example 3 Sample 3, Example 3 Sample 4, and Example 3 Sample 5.

[0048] The preparation method is as follows:

[0049] (1) Take purified water in the beaker according to the prescription amount;

[0050](2) Add the hydrogen peroxide of recipe quantity respectively in the beaker, and place the beaker in the ice bath, put into the stirrer and stir;

[0051] (3) Take the povidone-iodine of prescription quantity, slowly join in the beaker, stir until dissolving completely;

[0052] (4) Weigh the poloxamer (P188, P407) of the prescribed amount and slowly add it into the beaker until it is stirred an...

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Abstract

The invention discloses a temperature-sensitive gel preparation containing povidone iodine and used for treating cavity diseases caused by infection. The preparation is prepared from povidone iodine, a temperature-sensitive gel matrix, an oxidizing agent, an osmotic pressure regulator, a pH regulator and purified water. According to the invention, the problem of chemical incompatibility between povidone iodine and the temperature-sensitive gel matrix is well solved, so that the temperature-sensitive gel preparation containing povidone iodine is successfully prepared.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a temperature-sensitive gel preparation containing povidone-iodine for treating cavity diseases caused by infection. Background technique [0002] Povidone-iodine can directly denature and precipitate the protein in the bacteria, resulting in the death of pathogenic microorganisms, thereby effectively disinfecting and sterilizing bacteria, killing viruses, bacteria, spores, fungi, protozoa, etc., and has low toxicity. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Treponema pallidum, hepatitis B virus, HIV, Trichomonas vaginalis, etc. Povidone-iodine can continuously release free iodine, so that the skin and mucous membranes maintain a certain iodine-causing concentration, and inhibit and kill bacteria. [0003] One of the main uses of povidone-iodi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/79A61K47/10A61P15/02
CPCA61K9/06A61K9/0034A61K31/79A61K47/10A61P15/02
Inventor 梁波彭海洲
Owner IVEW THERAPEUTICS (ZHUHAI) CO LTD
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