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Compound composition containing recombinant collagen as well as preparation method and application of compound composition

A technology for recombining collagen and compounding compositions, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., which can solve the problem of unsatisfactory compounding effects of active ingredients, restrictions on the use of recombinant collagen, and unstable collagen activity results and other problems, achieve excellent moisturizing effect, smooth and tender skin, improve the effect of shrinking pores

Active Publication Date: 2022-04-01
河北纳科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While recombinant collagen has its advantages, there are also some problems, especially in facial mask liquid, its biggest defect is its instability, which greatly limits the use of recombinant collagen
CN106902381A discloses a recombinant human collagen stock solution, which is made by adding moisturizers, thickeners and preservatives to different recombinant human collagens. The stability is not good, and long-term storage affects the use effect
In addition, because of its stability problem, the effect of compounding with other active ingredients is not ideal, so there are few research reports on this type in the prior art. In order to overcome the defect of unstable collagen activity results, CN112494362 recombined human source Collagen and other ingredients are freeze-dried together with the mask to form a freeze-dried mask, which can be dissolved and used immediately. Although the stability of the recombinant human collagen is guaranteed to a certain extent, the product is easily damaged during transportation

Method used

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  • Compound composition containing recombinant collagen as well as preparation method and application of compound composition
  • Compound composition containing recombinant collagen as well as preparation method and application of compound composition
  • Compound composition containing recombinant collagen as well as preparation method and application of compound composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The composition of the composite beauty mask stoste containing recombinant collagen of the present embodiment is as follows (% represents mass percentage):

[0042]

[0043]

[0044] The solvent was prepared as follows:

[0045] (1) Dissolving low molecular weight hyaluronic acid in purified water to obtain phase ①;

[0046] (2) Dissolving ceramide, acetyl hexapeptide-8, nicotinamide, asiaticoside, α-arbutin, and glycerin in purified water to obtain phase ②;

[0047] (3) Mix phase ① and phase ② and stir evenly, add phenoxyethanol, make up the balance with purified water and stir evenly, and measure the pH value between 5.5-7.5;

[0048] (4) The obtained solution was sterilized by filtration, and divided into vials, 25ml / bottle, which was the component A-solution.

[0049] The preparation of freeze-dried ball comprises the following steps:

[0050] (1) Dissolving 0.5g trehalose in 5ml purified water to obtain phase c;

[0051] (2) 12.5mg of hyaluronic acid was di...

Embodiment 2

[0055] The composition of the composite beauty mask stoste containing recombinant collagen of the present embodiment is as follows (% represents mass percentage):

[0056]

[0057]

[0058] The preparation method is the same as in Example 1.

Embodiment 3

[0060] The composition of the composite beauty mask stoste containing recombinant collagen of the present embodiment is as follows (% represents mass percentage):

[0061]

[0062] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a compound composition containing recombinant collagen, the compound composition comprises a solvent and freeze-drying balls, the solvent comprises glycerin, low molecular weight sodium hyaluronate, ceramide 3, acetyl hexapeptide-8, nicotinamide, asiaticoside, alpha-arbutin and phenoxyethanol; the freeze-dried ball component comprises recombinant collagen, high-molecular sodium hyaluronate and a trehalose composite freeze-dried ball. Compared with the prior art, the composition is provided by adopting two components, contains polypeptide and plant essence, can reduce generation of dynamic wrinkles and eliminate fine wrinkles, effectively recombines collagen elasticity, can increase the activity of elastin, keeps the biological activity of recombinant collagen, assists in improving absorption of a human body, increases the epidermis repair speed and promotes wound healing, and has the advantages of no toxic or side effect and no toxic or side effect. The facial mask can relax facial lines, smooth wrinkles, moisturize and brighten skin color, improve skin grease, brighten and tighten the skin and make the skin bright, round and fresh.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, in particular, the invention relates to a compound composition containing recombinant collagen and its preparation and application. Background technique [0002] Collagen is the most abundant protein in the human body, distributed in various organs and tissues of our human body, and has the highest content in the dermis of the skin. The skin of young people is smooth, plump and elastic, the main reason is that collagen is more abundant. But after the age of 20, it decreases by 10% every year, and the human body shows a series of symptoms such as wrinkles, collapse, water shortage, spots, dull skin, enlarged pores, and sensitivity. In recent years, with the improvement of people's quality of life and people's pursuit of beauty, anti-aging and whitening and anti-wrinkle facial masks have been favored by more and more oriental women. The facial mask liquid is an important part of the facial mask...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/65A61K8/73A61K8/9789A61K8/60A61K8/68A61K8/64A61Q19/00A61Q19/02A61Q19/08
Inventor 徐兰举刘鑫曾海霞李华齐磊于月欣沈娟
Owner 河北纳科生物科技有限公司
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