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Chinese herbal medicine microbial fermentation preparation and preparation and application methods thereof

A technology of microbial fermentation and Chinese herbal medicine, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of growth inhibition of fermentation bacteria, difficulty in activity, and low utilization of traditional Chinese medicine, and achieve the ability to reduce growth inhibition and powerfully decompose and transform substances Effect

Pending Publication Date: 2022-04-19
上海颐久生物科技有限公司 +1
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AI Technical Summary

Problems solved by technology

[0004] At present, the preparation of microbial fermentation preparations of Chinese herbal medicines is mostly made by adding Chinese medicine extracts to the substrate for culture and fermentation. On the one hand, although liquid fermentation can shorten the fermentation time and improve production efficiency, the extraction efficiency is low and the utilization of Chinese medicines is not high. On the other hand On the one hand, traditional Chinese medicine extracts contain a large number of active ingredients, most of which have good antibacterial properties, which can easily cause the growth inhibition of fermentation bacteria, and the living bacteria in the preparation are easily inactivated by external environmental conditions, and it is difficult to be effective for a long time. keep alive

Method used

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  • Chinese herbal medicine microbial fermentation preparation and preparation and application methods thereof

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Embodiment 1

[0035] This embodiment relates to a preparation method of a Chinese herbal medicine microbial fermentation preparation, comprising the following steps:

[0036] (1) The Chinese herbal medicine composition is configured according to the following parts by weight ratio: 8-10 parts of medlar, 10-12 parts of astragalus, 4-6 parts of Cortex Phellodendri, 4-6 parts of Panax notoginseng, 12-15 parts of licorice, and 15-16 parts of malt and 6-8 parts of Poria cocos;

[0037] (2) Activate and expand the culture of photosynthetic bacteria (Rhodopseudomonas palustris), nitrogen-fixing bacteria (Azotobacter phenus), Bacillus licheniformis or Bacillus subtilis, and Lactobacillus rhamnosus with the culture medium, and expand the culture respectively 12h, and then mixed according to the ratio of the number of viable bacteria to 5:4:10:6 to obtain the first composite fermentation bacteria;

[0038]Activate the actinomycetes (Streptomyces), Lactobacillus acidophilus or Lactobacillus plantarum...

Embodiment 2

[0043] This embodiment relates to a preparation method of a Chinese herbal medicine microbial fermentation preparation, which is different from Embodiment 1 in that: the second composite fermentation bacteria also includes a modified montmorillonite carrier, which specifically includes the following steps:

[0044] (1) The Chinese herbal medicine composition is configured according to the following parts by weight ratio: 8-10 parts of medlar, 10-12 parts of astragalus, 4-6 parts of Cortex Phellodendri, 4-6 parts of Panax notoginseng, 12-15 parts of licorice, and 15-16 parts of malt and 6-8 parts of Poria cocos;

[0045] (2) Activate and expand the culture of photosynthetic bacteria (Rhodopseudomonas palustris), nitrogen-fixing bacteria (Azotobacter phenus), Bacillus licheniformis or Bacillus subtilis, and Lactobacillus rhamnosus with the culture medium, and expand the culture respectively 12h, and then mixed according to the ratio of the number of viable bacteria to 5:4:10:6 t...

experiment example

[0063] 1, the remaining viable count (lg value) of Chinese herbal medicine microbial fermentation preparation described in embodiment 1, embodiment 2 and comparative example under the same storage conditions is measured:

[0064] save time 0d 30d 60d 90d Example 1 7 6 5 3 Example 2 7 7 7 6 comparative example 7 7 6 5

[0065] 2. Select the animal model of hyperlipidemia rats for verification, select 50 male rats aged 8 weeks and weighing 200-225g, and after adaptive feeding for 3 days, divide them into 2 groups randomly.

[0066] Group (normal group: 10, high-fat model group: 40), adopt high-fat feed feeding method to build hyperlipidemia rat animal model, normal group eats normal basal feed, high-fat model group eats high-fat feed, Drink tap water sterilized by ultraviolet light, feed for 30 days, fast for 12 hours after 30 days, and take blood from the orbit to detect the content of total cholesterol, triglyceride and low-density l...

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Abstract

The invention provides a Chinese herbal medicine microbial fermentation preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine ferment.The preparation method comprises the following steps that a Chinese herbal medicine composition is crushed and mixed, water is added to adjust the humidity, then first compound zymophyte is inoculated for fermentation culture, and a solid-state fermentation product is prepared; taking the solid-state fermentation product as a raw material, and preparing a traditional Chinese medicine extracting solution through a solvent extraction method; taking the traditional Chinese medicine extracting solution as a fermentation substrate, and inoculating second compound zymophyte for fermentation culture to prepare the Chinese herbal medicine microbial fermentation preparation. According to the invention, through secondary fermentation, solid fermentation and liquid fermentation are combined, so that effective substances are relatively easy to dissolve out, the growth inhibition of an extracting solution on later fermentation is also reduced, and then the extracting solution is used as a secondary fermentation substrate, so that effective components and active substances of traditional Chinese medicines in the extracting solution are extracted to the maximum extent and are efficiently absorbed and utilized by a human body.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine fermentation, in particular to a Chinese herbal medicine microbial fermentation preparation and its preparation and application methods. Background technique [0002] Traditional Chinese medicine fermentation technology, also known as traditional Chinese medicine biotransformation technology, is based on inheriting traditional Chinese medicine fermentation and processing methods, combined with modern microecology, bioengineering, and fermentation engineering technology, to carry out biological transformation of the extracted active ingredients of Chinese medicine, and transform Chinese medicine The macromolecular substances are transformed by microorganisms into small molecular components that can be directly absorbed by the human intestine, so as to accelerate the absorption of traditional Chinese medicine and quantitatively treat diseases. Modern traditional Chinese medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P3/06
CPCA61K36/815A61K36/481A61K36/756A61K36/258A61K36/484A61K36/8998A61K36/076A61P3/06A61K2236/19A61K2300/00
Inventor 徐修文
Owner 上海颐久生物科技有限公司
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