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Pharmaceutical composition capable of treating pain and application thereof

A drug and combination technology, applied in the field of medicine, can solve problems such as adverse reactions, achieve strong and long-lasting analgesic effect, reduce the dosage of drugs, and reduce the effects of drug side effects

Pending Publication Date: 2022-04-29
JIANGSU OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are many drugs for treating pain, but due to problems such as adverse reactions and addiction, many defects and deficiencies appear in their clinical application, and they cannot meet the clinical needs well; the present invention is aimed at indomethacin, For the pharmacological performance of loxicam and duloxetine, a large number of tests were used to screen the combination and dosage, and two combined drugs with fast onset, strong and long-lasting analgesic effect, avoiding or reducing adverse reactions and their dosage combinations were explored

Method used

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  • Pharmaceutical composition capable of treating pain and application thereof
  • Pharmaceutical composition capable of treating pain and application thereof
  • Pharmaceutical composition capable of treating pain and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Paclitaxel-induced neuropathic pain in mice can be treated by combining indomethacin and duloxetine; see Example 1 for details;

Embodiment 2

[0040] Paclitaxel-induced neuropathic pain in mice can be treated by the combination of meloxicam and duloxetine; see Example 2 for details;

[0041] The inflammatory pain induced by carrageenan can be treated by the combination of indomethacin and duloxetine; see Example 3 for details;

[0042] The inflammatory pain induced by carrageenan can be treated by combination of meloxicam and duloxetine; see Example 4 for details.

[0043] Example 1: Evaluation of the efficacy of indomethacin combined with duloxetine on paclitaxel-induced neuropathic pain in mice

[0044] Experimental animals: adult male ICR mice, body weight (22±4g), purchased from Pizhou Dongfang Breeding Farm, certificate number: NO.202149615.

[0045] Experimental materials: indomethacin and paclitaxel were purchased from Shanghai Macklin Biochemical Technology Co., Ltd.; duloxetine, polyoxyethylene castor oil EL, and sodium carboxymethylcellulose were purchased from Shanghai Aladdin Biochemical Technology Co., ...

Embodiment 3

[0067] Example 3: Evaluation of the efficacy of indomethacin combined with duloxetine on carrageenan-induced inflammatory pain in rats

[0068] Experimental animals: adult male SD rats, body weight (240±30g), purchased from Pizhou Dongfang Farm, certificate number: NO.202149615.

[0069] Experimental materials: Indomethacin was purchased from Shanghai McLean Biochemical Technology Co., Ltd.; duloxetine, sodium carboxymethylcellulose, and carrageenan were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.; physiological saline was purchased from Jiangsu Huaian Shuang Crane Pharmaceutical Co., Ltd.

[0070] Preparation method: indomethacin: use 0.5% carboxymethylcellulose sodium solution as the solvent to prepare indomethacin suspension, the concentrations are 1.25mg / mL, 2.5mg / mL, 5mg / mL, 10mg / mL; Duloxetine: use normal saline as solvent to prepare duloxetine solution, the concentrations are 5mg / mL, 10mg / mL, 15mg / mL, 30mg / mL; carrageenan: use normal saline as solv...

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Abstract

The invention discloses a pharmaceutical composition capable of treating pain and application thereof, and relates to a pharmaceutical composition of an anti-inflammatory drug, 5-hydroxytryptamine and a noradrenaline reuptake inhibitor, the anti-inflammatory drug is indometacin and meloxicam, and the 5-hydroxytryptamine and noradrenaline reuptake inhibitor is duloxetine. The invention also relates to the use of said pharmaceutical composition in the prevention and / or treatment of pains caused by different tissue injuries or neuropathic causes. Experiments prove that the combination of the indometacin and the duloxetine and the combination of the meloxicam and the duloxetine have a synergistic or additive synergistic effect when being used for treating neuropathic pain induced by paclitaxel and inflammatory pain induced by carrageenan, and the composition shows a better analgesic effect compared with a single medicine; the effect is better than that of single medication, and the pharmaceutical composition has good clinical application value and application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a drug combination capable of treating pain and its application. Background technique [0002] Pain is an unpleasant sensory and emotional experience that occurs when the body is damaged, and is a clinical manifestation of complex pathological and physiological changes. Pain can be localized or a reflection of systemic diseases. People generally refer to diseases with the above "pain" as the main symptom as "pain". At present, opioid analgesics and non-steroidal anti-inflammatory drugs are classic clinical analgesics, which have a long history of pain treatment, but there are many defects and deficiencies in their clinical application, and the adverse reactions are also daunting . For example, some strong opioid analgesics that are clinically used for severe pain caused by postoperative surgery, trauma, cancer, etc. are prone to dependence in clinical application, and will produce a cer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4045A61K45/06A61P29/00A61P25/00A61K31/405A61K31/381A61K31/5415
CPCA61K31/4045A61K45/06A61P29/00A61P25/00A61K31/405A61K31/381A61K31/5415A61K2300/00
Inventor 庄涛马玉蓉张桂森
Owner JIANGSU OCEAN UNIV
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