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ITGA4 gene inhibitor and application of ITGA4 gene inhibitor in preparation of medicine for treating refractory or recurrent acute myelogenous leukemia

A gene inhibition and inhibitor technology, applied in gene therapy, application, drug combination, etc., can solve problems such as unclear target

Pending Publication Date: 2022-04-29
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the role of VLA-4 in refractory or relapsed leukemia has not been reported, and whether VLA-4 can be used as a target for the treatment of refractory or relapsed AML is still unclear

Method used

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  • ITGA4 gene inhibitor and application of ITGA4 gene inhibitor in preparation of medicine for treating refractory or recurrent acute myelogenous leukemia
  • ITGA4 gene inhibitor and application of ITGA4 gene inhibitor in preparation of medicine for treating refractory or recurrent acute myelogenous leukemia
  • ITGA4 gene inhibitor and application of ITGA4 gene inhibitor in preparation of medicine for treating refractory or recurrent acute myelogenous leukemia

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Embodiment

[0046] 1: Materials and methods

[0047] (1), cell line

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Abstract

The invention provides an ITGA4 gene inhibitor and application of the ITGA4 gene inhibitor in preparation of drugs for treating refractory or recurrent acute myelogenous leukemia, and belongs to the technical field of biological medicines. According to the invention, ITGA4 is found to be a potential treatment target of intractable or recurrent leukemia, so that an inhibitor comprising shRNA (short hairpin ribonucleic acid) and / or a natau monoclonal antibody of which the nucleotide sequence is SEQ ID NO: 1 is selected. The inhibitor is applied to preparation of drugs for treating refractory or recurrent acute myelogenous leukemia. According to the invention, expression or activity of ITGA4 is clearly reduced, and proliferation of leukemia cells is inhibited; the survival of leukemia mice is obviously prolonged; and the homing of leukemia cells is weakened.

Description

technical field [0001] The technical field of biomedicine of the present invention particularly refers to an ITGA4 gene inhibitor and its application in the preparation of drugs for refractory or relapsed acute myeloid leukemia. Background technique [0002] Acute myeloid leukemia (AML) is a hematological tumor in which myeloid leukocytes proliferate abnormally. It is one of the most common hematological malignancies in adults, and its fatality rate accounts for the top ten of various tumors. About 10-40% of young AML patients and 40-60% of elderly patients cannot achieve complete remission with induction chemotherapy. After intensive chemotherapy, the 10-year disease-free survival rate of AML patients under 60 years old is 16%, and the 10-year disease-free survival rate of patients over 60 years old The survival rate is only 2%. Nearly 50% of patients relapse after induction chemotherapy. The prognosis of patients with relapsed or refractory AML is poor, and the 3-year ov...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K39/395A61P35/02C12N15/867C12N7/01C12N15/113
CPCA61K48/005A61K48/0008A61K39/395A61P35/02C12N15/86C12N7/00C12N15/113C12N2740/15043C12N2740/15021C12N2310/141A61K2300/00
Inventor 吴德沛刘天会徐杨齐丽娟张聚斌王谈真
Owner SUZHOU UNIV
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