Online solid-phase microextraction and high-performance liquid chromatography combined detection method for novel benzodiazepine drugs
A technology of high performance liquid chromatography and benzodiazepines, which is applied in the field of analytical chemistry, can solve problems such as endangering the health of consumers, achieve high-efficiency enrichment extraction and high-sensitivity online detection, improve extraction efficiency, and enhance π-π The effect of accumulation
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[0030] Example
[0031] Step 1. Preparation of covalent organic framework surface-functionalized solid-phase microextraction monolithic column:
[0032] 1. Preparation of poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) monolithic column:
[0033] 1) Cleaning of the stainless steel tube empty column: Connect the stainless steel empty column with a length of 33 mm and an inner diameter of 2.1 mm to the liquid phase pump, and rinse it with chromatographic pure methanol at a flow rate of 1.0 mL / min for 20 minutes to remove the residue on the inner wall of the stainless steel tube. The impurities were then dried in an oven at 60 °C for 2 hours.
[0034] 2) In-tube free radical copolymerization: 300 mg of glycidyl methacrylate, 100 mg of ethylene glycol dimethacrylate, 120 mg of N,N-dimethylformamide, 480 mg of 1,4-butanediol, After 1.2 mg of azobisisobutyronitrile was mixed with a vortex mixer, it was sonicated for 15 minutes at room temperature (the ultrasonic freq...
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