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Bladder perfusion medicine composition as well as preparation method and application thereof

A technology of bladder perfusion and composition, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve the problems of poor bladder cancer inhibition effect, patient tolerance, prognosis, adverse reactions, etc.

Pending Publication Date: 2022-07-01
SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Simple perfusion chemotherapy is not effective in inhibiting the progression of bladder cancer, and it is prone to toxic and side effects and adverse reactions. Patients are easily tolerated and the prognosis is not ideal.

Method used

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  • Bladder perfusion medicine composition as well as preparation method and application thereof
  • Bladder perfusion medicine composition as well as preparation method and application thereof
  • Bladder perfusion medicine composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment A

[0043] Embodiment A: preparation compatibility

Embodiment A1

[0044] Example A1: Weigh 10 mg of R837, add 5 mL of hydrochloric acid with a concentration of 0.015 M, and shake until the solution is completely clear. The ICD chemotherapeutic drug doxorubicin hydrochloride is added to the solution, and the mass ratio of imiquimod to doxorubicin hydrochloride is 1:1, 2:1, 4:1, 6:1 and 10:1. Add a suitable freeze-drying auxiliary solvent such as mannitol, add a pH adjuster such as sodium hydroxide, control the pH value between 2.0-5.5, and freeze-dry to prepare a freeze-dried powder.

Embodiment A2

[0045] Example A2: Weigh 10 mg of R837, add 5 mL of hydrochloric acid with a concentration of 0.015 M, and shake until the solution is completely clear. The ICD chemotherapeutic drug epirubicin hydrochloride was added to the solution, and the mass ratios of imiquimod and epirubicin hydrochloride were 1:1, 2:1, 4:1, 6:1 and 10:1. Add a suitable freeze-drying auxiliary solvent such as mannitol, add a pH adjuster such as sodium hydroxide, control the pH value between 2.0-5.5, and freeze-dry to prepare a freeze-dried powder.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for bladder perfusion. The pharmaceutical composition comprises soluble salt of an immunologic adjuvant and a chemical drug capable of causing death of immunogenic cells. Pharmaceutical compositions useful in or for the treatment of bladder cancer. When the soluble salt of the immunologic adjuvant is combined with a chemical drug capable of causing death of immunogenic cells as a bladder perfusion drug, the side effect of the chemical drug can be reduced, a synergistic anti-cancer effect can be generated, the cancer metastasis and recurrence probability can be reduced, and the existence of the immunologic adjuvant promotes a large number of macrophages to be enriched around tumor tissues of the bladder, so that the cancer metastasis and recurrence probability can be reduced. After the ICD drug plays a role in initial chemotherapy and immune excitation, macrophages can swallow a large number of tumor extracellular free chemotherapeutic drugs, and damage of the chemotherapeutic drugs to normal tissues can be reduced, so that systematic toxic and side effects of ICD chemical drugs are reduced.

Description

technical field [0001] The invention relates to the field of medicines for tumor treatment, in particular to a pharmaceutical composition for intravesical instillation and a preparation method and pharmaceutical application thereof. Background technique [0002] Bladder cancer is a common urinary system tumor. Although compared with lung cancer and gastrointestinal tumors, bladder cancer has lower morbidity and mortality, but its high recurrence rate has made bladder cancer one of the most expensive cancers in clinical treatment. . Infusion chemotherapy after transurethral tumor resection for bladder cancer is the first choice for bladder cancer treatment, but the current clinical infusion therapy has low clinical absolute remission rate, high tumor recurrence rate, serious side effects, and poor patient prognosis. At the same time, in recent years, the incidence of bladder cancer in my country has been increasing year by year, which is higher than the world average. In the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/4745A61K31/437A61K9/19A61K47/26A61P35/00A61P35/04
CPCA61K45/06A61K31/4745A61K31/437A61K9/19A61K9/0034A61K47/26A61P35/00A61P35/04A61K2300/00
Inventor 刘庄邓中清吴松吴宇辰李广志许欢
Owner SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
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