Bladder perfusion medicine composition as well as preparation method and application thereof

A technology of bladder perfusion and composition, applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., can solve the problems of poor bladder cancer inhibition effect, patient tolerance, prognosis, adverse reactions, etc.
CN114681612APending Publication Date: 2022-07-01SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU INNOVATIVE BIOMATERIALS & PHARM CO LTD
Publication Date
2022-07-01

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Abstract

The invention discloses a pharmaceutical composition for bladder perfusion. The pharmaceutical composition comprises soluble salt of an immunologic adjuvant and a chemical drug capable of causing death of immunogenic cells. Pharmaceutical compositions useful in or for the treatment of bladder cancer. When the soluble salt of the immunologic adjuvant is combined with a chemical drug capable of causing death of immunogenic cells as a bladder perfusion drug, the side effect of the chemical drug can be reduced, a synergistic anti-cancer effect can be generated, the cancer metastasis and recurrence probability can be reduced, and the existence of the immunologic adjuvant promotes a large number of macrophages to be enriched around tumor tissues of the bladder, so that the cancer metastasis and recurrence probability can be reduced. After the ICD drug plays a role in initial chemotherapy and immune excitation, macrophages can swallow a large number of tumor extracellular free chemotherapeutic drugs, and damage of the chemotherapeutic drugs to normal tissues can be reduced, so that systematic toxic and side effects of ICD chemical drugs are reduced.
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Description

technical field

[0001] The invention relates to the field of medicines for tumor treatment, in particular to a pharmaceutical composition for intravesical instillation and a preparation method and pharmaceutical application thereof. Background technique

[0002] Bladder cancer is a common urinary system tumor. Although compared with lung cancer and gastrointestinal tumors, bladder cancer has lower morbidity and mortality, but its high recurrence rate has made bladder cancer one of the most expensive cancers in clinical treatment. . Infusion chemotherapy after transurethral tumor resection for bladder cancer is the first choice for bladder cancer treatment, but the current clinical infusion therapy has low clinical absolute remission rate, high tumor recurrence rate, serious side effects, and poor patient prognosis. At the same time, in recent years, the incidence of bladder cancer in my country has been increasing year by year, which is higher than the world average. In the...

Claims

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