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Novel multifunctional fluid device for clamping biopsy tissue

A fluid and fluid connection technology, applied in laboratory containers, applications, inoculation and ovulation diagnosis, etc., can solve problems such as loss of orientation, difficulties in tissue samples, and obstacles to 3D structure investigations

Pending Publication Date: 2022-07-08
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] While some fluidic devices are foreseeable within the above expectations, there are difficulties in using such devices to prepare tissue samples
For example, when tissue samples are placed on the surfaces of the flow chambers of such devices, such surfaces typically impair the perfusion of fluids and reduce the transparency required for microscopic investigations
On the other hand, when biopsy tissue is allowed to move freely in the flow chamber, its orientation will be lost after a period of time, which may prevent accurate investigation of the most diagnostic regions or 3D structure of the tissue sample.

Method used

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  • Novel multifunctional fluid device for clamping biopsy tissue
  • Novel multifunctional fluid device for clamping biopsy tissue
  • Novel multifunctional fluid device for clamping biopsy tissue

Examples

Experimental program
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Embodiment Construction

[0055] refer to figure 1 , a fluidic device 1 as disclosed herein comprises a flow chamber 2 for containing a biological sample on a microporous carrier portion 3 and at least one flow channel 4, 4a, 4b, 4c, 4d in fluid connection with the flow chamber 2. as from image 3 and Figure 4 As can be better seen in the sectional view of , the fluidic device 1 has a layered structure comprising a base plate 5, a cover plate 6 and an insert 7 located between them. Furthermore, the insert 7 comprises a microporous carrier part 3 and a frame part 8 surrounding the microporous carrier part 3 and is modified or can be modified with cutouts 9 provided in the microporous carrier part 3, as in figure 2 can be seen in. According to the present invention, the insert 7 is elastomeric in order to provide a gripping mechanism for the biological sample as described herein.

[0056] In order to prevent damage to the biological sample, the insert 7 is adapted so that the opening defined by the...

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PUM

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Abstract

A fluidic device (1) comprising a flow chamber (2) for containing a biological sample on a carrier portion (3) and at least one flow channel (4a, 4b, 4c, 4d) fluidly connected to the flow chamber (2), the fluidic device (1) having a layered structure comprising a bottom plate (5), a cover plate (6) and an insert (7) located therebetween, the insert (7) comprising a carrier portion (3) and a frame portion surrounding the carrier portion (3), and elastomeric so as to be able to clamp the biological sample between the incisions in the carrier part (3).

Description

technical field [0001] The present invention relates to a device for holding a biological sample in a fixed orientation and / or for supplying a fluid to a biological sample. The invention also relates to an insert for such a device, and a kit comprising such an insert and at least one cover plate, which together with the insert can provide the device of the invention. The invention also relates to a system comprising the insert or device of the invention. The invention also relates to the use of an insert, kit or device for holding a biological sample in a fixed orientation and / or for supplying a fluid to a biological sample. Background technique [0002] A prostate biopsy is a procedure in which a small sample of tissue (biopsy tissue) is removed from a patient's prostate to check for the presence of prostate cancer. In most cases, a hollow needle is used to separate out cylindrical samples with a diameter of about 1 mm and a length, for example, between 5 and 20 mm meters...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502715B01L2300/0609B01L2300/0877B01L2300/0887B01L2300/123A61B10/0096B01L2300/163B01L3/502707B01L2200/12B01L2300/168
Inventor L·J·A·M·贝克尔斯
Owner KONINKLJIJKE PHILIPS NV